HCN-encoded pacemaker channels: from physiology and biophysics to bioengineering (Q36844782)

16 August 2017

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title

HCN-encoded pacemaker channels: from physiology and biophysics to bioengineering (English)

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16 August 2017

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Siu CW

1

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16 August 2017

Lieu DK

series ordinal

2

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16 August 2017

Li RA

series ordinal

3

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16 August 2017

publication date

1 January 2006

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16 August 2017

number of pages

8

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Journal of Membrane Biology

inferred from page(s)

published in

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16 August 2017

volume

214

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16 August 2017

issue

3

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16 August 2017

page(s)

115-122

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Biological pacemaker implanted in canine left bundle branch provides ventricular escape rhythms that have physiologically acceptable rates

16 August 2017

cites work

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12 December 2020

Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4

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12 December 2020

Changes in local S4 environment provide a voltage-sensing mechanism for mammalian hyperpolarization-activated HCN channels

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12 December 2020

Mechanistic role of I(f) revealed by induction of ventricular automaticity by somatic gene transfer of gating-engineered pacemaker (HCN) channels

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12 December 2020

Structure and function of cardiac pacemaker channels

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12 December 2020

Molecular mechanism of cAMP modulation of HCN pacemaker channels.

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12 December 2020

Voltage sensor of Kv1.2: structural basis of electromechanical coupling

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12 December 2020

I(f) and the biological pacemaker

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12 December 2020

Non-equilibrium behavior of HCN channels: insights into the role of HCN channels in native and engineered pacemakers

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12 December 2020

The moving parts of voltage-gated ion channels

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12 December 2020

Pore-to-gate coupling of HCN channels revealed by a pore variant that contributes to gating but not permeation

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12 December 2020

Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells.

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12 December 2020

Differential distribution and function of hyperpolarization-activated channels in sensory neurons and mechanosensitive fibers.

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12 December 2020

HCN2 overexpression in newborn and adult ventricular myocytes: distinct effects on gating and excitability

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12 December 2020

Mutations in the S4 domain of a pacemaker channel alter its voltage dependence

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12 December 2020

Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide

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12 December 2020

Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain

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12 December 2020

The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart

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12 December 2020

Molecular basis of the effect of potassium on heterologously expressed pacemaker (HCN) channels

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12 December 2020

Premonitions of ion channel gating

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12 December 2020

If in left human atrium: a potential contributor to atrial ectopy

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12 December 2020

Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis

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12 December 2020

Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues

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12 December 2020

Atomic structure of a Na+- and K+-conducting channel

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12 December 2020

Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel

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12 December 2020

A family of hyperpolarization-activated mammalian cation channels

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12 December 2020

Heteromeric HCN1-HCN4 channels: a comparison with native pacemaker channels from the rabbit sinoatrial node

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12 December 2020

Identification of a surface charged residue in the S3-S4 linker of the pacemaker (HCN) channel that influences activation gating

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12 December 2020

Voltage-sensing mechanism is conserved among ion channels gated by opposite voltages.

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12 December 2020

Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN Channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model

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12 December 2020

The HCN gene family: molecular basis of the hyperpolarization-activated pacemaker channels

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12 December 2020

Hyperpolarization-activated inward current in ventricular myocytes from normal and failing human hearts

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12 December 2020

An external determinant in the S5-P linker of the pacemaker (HCN) channel identified by sulfhydryl modification

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12 December 2020

The Properties of the Pacemaker Current IFin Human Ventricular Myocytes are Modulated by Cardiac Disease

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12 December 2020

Using the deadly mu-conotoxins as probes of voltage-gated sodium channels

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12 December 2020

Two pacemaker channels from human heart with profoundly different activation kinetics

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12 December 2020

Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS.

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12 December 2020

The voltage sensor in voltage-dependent ion channels

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12 December 2020

Structure and function of cyclic nucleotide-gated channels

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12 December 2020

Dominant-negative suppression of HCN1- and HCN2-encoded pacemaker currents by an engineered HCN1 construct: insights into structure-function relationships and multimerization

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12 December 2020

Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative suppression

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12 December 2020

Dissecting the structural and functional roles of the S3-S4 linker of pacemaker (hyperpolarization-activated cyclic nucleotide-modulated) channels by systematic length alterations

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12 December 2020

Characterization of the hyperpolarization-activated current, I(f), in ventricular myocytes isolated from hypertensive rats

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12 December 2020

Dominant-negative suppression of HCN channels markedly reduces the native pacemaker current I(f) and undermines spontaneous beating of neonatal cardiomyocytes.

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12 December 2020

Determinants of activation kinetics in mammalian hyperpolarization-activated cation channels

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12 December 2020

Reversal of HCN channel voltage dependence via bridging of the S4-S5 linker and Post-S6.

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12 December 2020

Voltage sensing and activation gating of HCN pacemaker channels

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12 December 2020

Expression and function of a biological pacemaker in canine heart

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12 December 2020

Critical intra-linker interactions of HCN1-encoded pacemaker channels revealed by interchange of S3-S4 determinants

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12 December 2020

Molecular Coupling between Voltage Sensor and Pore Opening in the Arabidopsis Inward Rectifier K+ Channel KAT1

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12 December 2020

Characterization of the hyperpolarization-activated current, I(f), in ventricular myocytes from human failing heart

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12 December 2020

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

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12 December 2020

Wild-type and mutant HCN channels in a tandem biological-electronic cardiac pacemaker.

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12 December 2020

Regional distribution of hyperpolarization‐activated current (If) and hyperpolarization‐activated cyclic nucleotide‐gated channel mRNA expression in ventricular cells from control and hypertrophied rat hearts

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12 December 2020

Hyperpolarization-activated cation currents: from molecules to physiological function

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12 December 2020

Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain.

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12 December 2020

Helical secondary structure of the external S3-S4 linker of pacemaker (HCN) channels revealed by site-dependent perturbations of activation phenotype

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12 December 2020

Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers

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12 December 2020

Mutations in the K+ channel signature sequence

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12 December 2020

Stem cells as biological heart pacemakers

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12 December 2020

Cooperative gating between single HCN pacemaker channels

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12 December 2020

Molecular mechanisms of cyclic nucleotide-gated channels

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12 December 2020

Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli

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12 December 2020

Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2

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12 December 2020

Functional heteromerization of HCN1 and HCN2 pacemaker channels

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12 December 2020

Functional roles of charged residues in the putative voltage sensor of the HCN2 pacemaker channel.

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12 December 2020

10.1007/S00232-006-0881-9

Identifiers

DOI

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16 August 2017

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