DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer (Q36855596)

16 August 2017

DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer (English)

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16 August 2017

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Catherine R Sears

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16 August 2017

Sean A Cooney

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16 August 2017

Helen Chin-Sinex

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3

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16 August 2017

Marc S Mendonca

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4

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16 August 2017

John J Turchi

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16 August 2017

language of work or name

English

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publication date

3 March 2016

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16 August 2017

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16 August 2017

40

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16 August 2017

35-46

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describes a project that uses

16 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4852375/fullTextXML

inferred from PubMed Central ID database lookup

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Cisplatin-mediated radiosensitization of non-small cell lung cancer cells is stimulated by ATM inhibition.

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Current treatments for advanced stage non-small cell lung cancer

29 September 2017

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Kinetics of H2AX phosphorylation after exposure to cisplatin

29 September 2017

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29 September 2017

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Phosphorylated histone H2AX in relation to cell survival in tumor cells and xenografts exposed to single and fractionated doses of X-rays

29 September 2017

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Cisplatin sensitizes cancer cells to ionizing radiation via inhibition of nonhomologous end joining

29 September 2017

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Inhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extracts

29 September 2017

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A comparison of response to cisplatin, radiation and combined treatment for cells deficient in recombination repair pathways

29 September 2017

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

29 September 2017

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ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

29 September 2017

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Examining the non-homologous repair process following cisplatin and radiation treatments

29 September 2017

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Mechanisms of resistance to cisplatin

29 September 2017

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Cisplatin-DNA adducts inhibit translocation of the Ku subunits of DNA-PK.

29 September 2017

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29 September 2017

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29 September 2017

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

29 September 2017

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The molecular basis for cell cycle delays following ionizing radiation: a review

29 September 2017

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Alteration and activation of sequence-specific cleavage of DNA by bleomycin in the presence of the antitumor drug cis-diamminedichloroplatinum(II)

29 September 2017

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Carboplatin- and cisplatin-induced potentiation of moderate-dose radiation cytotoxicity in human lung cancer cell lines

29 September 2017

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The effect of combined treatment with platinum complexes and ionizing radiation on DNA in vitro.

29 September 2017

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Non-DSB clustered DNA lesions induced by ionizing radiation are largely responsible for the loss of plasmid DNA functionality in the presence of cisplatin.

29 September 2017

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Cisplatin enhances the formation of DNA single- and double-strand breaks by hydrated electrons and hydroxyl radicals

4 September 2018

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gammaH2AX expression in tumors exposed to cisplatin and fractionated irradiation

4 September 2018

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Long-term in vivo effects of cisplatin on gamma-H2AX foci signaling in peripheral lymphocytes of tumor patients after irradiation.

4 September 2018

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Changes in the natural history of nonsmall cell lung cancer (NSCLC)--comparison of outcomes and characteristics in patients with advanced NSCLC entered in Eastern Cooperative Oncology Group trials before and after 1990.

4 September 2018

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Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody

4 September 2018

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P53 plays a protective role against UV- and cisplatin-induced apoptosis in transcription-coupled repair proficient fibroblasts.

4 September 2018

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Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours

4 September 2018

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12 December 2020

Cisplatin-modification of DNA repair and ionizing radiation lethality in yeast, Saccharomyces cerevisiae

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Differential mechanisms of x-ray-induced cell death in human endothelial progenitor cells isolated from cord blood and adults

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12 December 2020

Flow cytometric analysis of the kinetic effects of cisplatin on lung cancer cells

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12 December 2020

Induction of DNA double-strand breaks by X-rays in a radiosensitive strain of the yeast Saccharomyces cerevisiae

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12 December 2020

Human Ku autoantigen binds cisplatin-damaged DNA but fails to stimulate human DNA-activated protein kinase

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12 December 2020

10.1016/J.DNAREP.2016.02.004

Identifiers

DOI

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16 August 2017

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16 August 2017

PubMed publication ID

26991853

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