Ion channels and regulation of insulin secretion in human β-cells: a computational systems analysis (Q36870356)

16 August 2017

10 references

5 August 2019

19 September 2019

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27 January 2021

Ion channels and regulation of insulin secretion in human β-cells: a computational systems analysis (English)

1 reference

biomedical investigative technique

16 August 2017

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5 August 2019

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19 September 2019

human digestive system

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7 October 2019

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12 October 2019

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17 November 2019

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28 November 2019

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15 December 2019

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insulin-secreting cells

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27 January 2021

Leonid E Fridlyand

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16 August 2017

David A Jacobson

series ordinal

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16 August 2017

L H Philipson

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16 August 2017

1 January 2013

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16 August 2017

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Creative Commons Attribution-NonCommercial 3.0 Unported

16 August 2017

10 references

5 August 2019

19 September 2019

7 October 2019

10 October 2019

12 October 2019

17 November 2019

20 November 2019

28 November 2019

15 December 2019

Regulation of insulin secretion in human pancreatic islets

27 January 2021

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Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus

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The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic beta-cell line

29 September 2017

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2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces calcium influx through T-type calcium channel and enhances lysosomal exocytosis and insulin secretion in INS-1 cells

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Regulation of insulin secretion: a matter of phase control and amplitude modulation

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Activation of Ca(2+)-dependent K(+) channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells

29 September 2017

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29 September 2017

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29 September 2017

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Cloning of human pancreatic islet large conductance Ca(2+)-activated K+ channel (hSlo) cDNAs: evidence for high levels of expression in pancreatic islets and identification of a flanking genetic marker

29 September 2017

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Contributions of modeling to understanding stimulus-secretion coupling in pancreatic beta-cells

29 September 2017

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Minimal model for membrane oscillations in the pancreatic beta-cell

29 September 2017

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ATP-sensitive potassium channel and bursting in the pancreatic beta cell. A theoretical study

29 September 2017

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Electrophysiology of the pancreatic beta-cell

29 September 2017

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Na channels and two types of Ca channels in rat pancreatic B cells identified with the reverse hemolytic plaque assay

29 September 2017

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Delayed rectifying and calcium-activated K+ channels and their significance for action potential repolarization in mouse pancreatic beta-cells

29 September 2017

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Electrophysiology of stimulus-secretion coupling in human beta-cells

29 September 2017

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Block of Kv1.7 potassium currents increases glucose-stimulated insulin secretion

29 September 2017

1 reference

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BK channels mediate a novel ionic mechanism that regulates glucose-dependent electrical activity and insulin secretion in mouse pancreatic β-cells

27 June 2018

1 reference

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Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human islets

27 June 2018

1 reference

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NALCN: a regulated leak channel

27 June 2018

1 reference

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Participation of Na(+) channels in the potentiation by Tityus serrulatus alpha-toxin TsTx-V of glucose-induced electrical activity and insulin secretion in rodent islet beta-cells

27 June 2018

1 reference

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Role of voltage-dependent Na+ channels for rhythmic Ca2+ signalling in glucose-stimulated mouse pancreatic beta-cells

27 June 2018

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Voltage-dependent Na+ and Ca2+ currents in human pancreatic islet beta-cells: evidence for roles in the generation of action potentials and insulin secretion.

27 June 2018

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Glucose induces oscillatory Ca2+ signalling and insulin release in human pancreatic beta cells

27 June 2018

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27 June 2018

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Ranolazine increases β-cell survival and improves glucose homeostasis in low-dose streptozotocin-induced diabetes in mice

27 June 2018

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A biophysical model of electrical activity in human β-cells.

4 September 2018

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Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses

4 September 2018

1 reference

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Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.

4 September 2018

1 reference

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Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion.

4 September 2018

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The Walter B. Cannon Physiology in Perspective Lecture, 2007. ATP-sensitive K+ channels and disease: from molecule to malady

4 September 2018

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Maintenance of stimulus-secretion coupling and single beta-cell function in cryopreserved-thawed human islets of Langerhans

4 September 2018

1 reference

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Small-conductance calcium-activated K+ channels are expressed in pancreatic islets and regulate glucose responses

4 September 2018

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Modeling of Ca2+ flux in pancreatic beta-cells: role of the plasma membrane and intracellular stores

4 September 2018

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Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets.

4 September 2018

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Effects of veratridine on sodium currents and fluxes.

4 September 2018

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T-type calcium channels facilitate insulin secretion by enhancing general excitability in the insulin-secreting beta-cell line, INS-1.

4 September 2018

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Glucose-induced electrical activity in the pancreatic beta-cell: effect of veratridine.

4 September 2018

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A fluorimetric and amperometric study of calcium and secretion in isolated mouse pancreatic ?-cells

4 September 2018

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Cloning of human pancreatic islet large conductance Ca2+-activated K+ channel (hSlo) cDNAs: evidence for high levels of expression in pancreatic islets and identification of a flanking genetic marker

21 January 2018

1 reference

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

21 January 2018

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Glucose Induces Opposite Intracellular Ca2+Concentration Oscillatory Patterns in Identified α- and β-Cells Within Intact Human Islets of Langerhans

21 January 2018

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Genome-wide association studies-derived susceptibility loci in type 2 diabetes: confirmation in a Chinese population

21 January 2018

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12 December 2020

Glucose- and arginine-induced insulin secretion by human pancreatic beta-cells: the role of HERG K(+) channels in firing and release

1 reference

12 December 2020

Human, rodent, and canine pancreatic beta-cells express a sodium channel alpha 1-subunit related to a fetal brain isoform

1 reference

12 December 2020

Glucose-induced [Ca2+]i oscillations in single human pancreatic islets

1 reference

12 December 2020

Identifiers

DOI

10.4161/ISL.24166

1 reference

16 August 2017

1 reference

16 August 2017

PubMed publication ID

23624892

1 reference