Tolerogenic dendritic cells and the quest for transplant tolerance (Q36879029)

16 August 2017

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title

Tolerogenic dendritic cells and the quest for transplant tolerance (English)

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16 August 2017

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2

Angus W Thomson

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16 August 2017

Adrian E Morelli

1

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16 August 2017

13 July 2007

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Nature Reviews Immunology

16 August 2017

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16 August 2017

7

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16 August 2017

610-621

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16 August 2017

8

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Dendritic cells and the control of immunity

16 August 2017

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Tolerogenic dendritic cells

31 March 2020

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Steady-state and inflammatory dendritic-cell development

31 March 2020

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CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen

31 March 2020

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The dendritic cell populations of mouse lymph nodes.

31 March 2020

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The lymphoid past of mouse plasmacytoid cells and thymic dendritic cells

31 March 2020

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Mouse and human dendritic cell subtypes

31 March 2020

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Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology

31 March 2020

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CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells

31 March 2020

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Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice

31 March 2020

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Phenotype and function of rat dendritic cell subsets

31 March 2020

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Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo

31 March 2020

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Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity.

31 March 2020

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Tolerogenic semimature dendritic cells suppress experimental autoimmune thyroiditis by activation of thyroglobulin-specific CD4+CD25+ T cells

31 March 2020

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Dendritic cells: emerging pharmacological targets of immunosuppressive drugs

31 March 2020

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Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction

31 March 2020

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Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression

31 March 2020

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Rapamycin inhibits IL-4--induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo

31 March 2020

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Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance

31 March 2020

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Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance

31 March 2020

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1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation

31 March 2020

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Potent inhibition of dendritic cell differentiation and maturation by vitamin D analogs

31 March 2020

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In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

31 March 2020

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Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance.

31 March 2020

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Mobilizing dendritic cells for tolerance by engagement of immune inhibitory receptors for HLA-G.

31 March 2020

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Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig

31 March 2020

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Immune modulation by silencing IL-12 production in dendritic cells using small interfering RNA.

31 March 2020

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Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified

31 March 2020

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Prevention of peripheral tolerance by a dendritic cell growth factor: flt3 ligand as an adjuvant

31 March 2020

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Dendritic cell subsets in blood and lymphoid tissue of rhesus monkeys and their mobilization with Flt3 ligand

31 March 2020

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Promotion of skin graft tolerance across MHC barriers by mobilization of dendritic cells in donor hemopoietic cell infusions

31 March 2020

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Normal donor bone marrow is superior to Flt3 ligand-mobilized bone marrow in prolonging heart allograft survival when combined with anti-CD40L (CD154)

31 March 2020

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In vivo-mobilized kidney dendritic cells are functionally immature, subvert alloreactive T-cell responses, and prolong organ allograft survival.

31 March 2020

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Direct and indirect recognition: the role of MHC antigens in graft rejection

31 March 2020

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A novel pathway of alloantigen presentation by dendritic cells

31 March 2020

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Indirect activation of naïve CD4+ T cells by dendritic cell-derived exosomes

31 March 2020

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Dendritic cells acquire antigens from live cells for cross-presentation to CTL.

31 March 2020

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Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy

31 March 2020

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Bone marrow-derived dendritic cell progenitors (NLDC 145+, MHC class II+, B7-1dim, B7-2-) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes

31 March 2020

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Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients

31 March 2020

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Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo

31 March 2020

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Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome function.

31 March 2020

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Characterization of Dendritic Cells that Induce Tolerance and T Regulatory 1 Cell Differentiation In Vivo

31 March 2020

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Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells

31 March 2020

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Effective expansion of alloantigen-specific Foxp3+ CD25+ CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reaction

31 March 2020

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CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.

31 March 2020

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Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival

31 March 2020

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Operational tolerance induced by pretreatment with donor dendritic cells under blockade of CD40 pathway

31 March 2020

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Monocyte-derived dendritic cell precursors facilitate tolerance to heart allografts after total lymphoid irradiation.

31 March 2020

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B7-H1 (programmed death-1 ligand) on dendritic cells is involved in the induction and maintenance of T cell anergy.

31 March 2020

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Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase

31 March 2020

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Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells.

31 March 2020

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Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4

31 March 2020

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CD4(+) and CD8(+) anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity

31 March 2020

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Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells

31 March 2020

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Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells

31 March 2020

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A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis

31 March 2020

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The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens

31 March 2020

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Differential antigen processing by dendritic cell subsets in vivo

31 March 2020

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CD40 ligation ablates the tolerogenic potential of lymphoid dendritic cells

31 March 2020

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IFN-gamma inhibits presentation of a tumor/self peptide by CD8 alpha- dendritic cells via potentiation of the CD8 alpha+ subset

31 March 2020

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Modulation of tryptophan catabolism by regulatory T cells.

31 March 2020

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Kynurenine pathway enzymes in dendritic cells initiate tolerogenesis in the absence of functional IDO

31 March 2020

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CTLA-4-Ig regulates tryptophan catabolism in vivo.

31 March 2020

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IDO expression by dendritic cells: tolerance and tryptophan catabolism

31 March 2020

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Immature and mature CD8alpha+ dendritic cells prolong the survival of vascularized heart allografts

31 March 2020

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The nature of the principal type 1 interferon-producing cells in human blood

31 March 2020

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Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens

31 March 2020

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Reciprocal control of T helper cell and dendritic cell differentiation

31 March 2020

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Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells

31 March 2020

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Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells

31 March 2020

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Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand

31 March 2020

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Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagement

31 March 2020

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Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy

31 March 2020

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Plasmacytoid precursor dendritic cells facilitate allogeneic hematopoietic stem cell engraftment

31 March 2020

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Plasmacytoid dendritic cell precursors induce allogeneic T-cell hyporesponsiveness and prolong heart graft survival

31 March 2020

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Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells

31 March 2020

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NK cells promote transplant tolerance by killing donor antigen-presenting cells

31 March 2020

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Indirect allorecognition in acquired thymic tolerance: induction of donor-specific tolerance to rat cardiac allografts by allopeptide-pulsed host dendritic cells

31 March 2020

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Major histocompatibility complex class I peptide-pulsed host dendritic cells induce antigen-specific acquired thymic tolerance to islet cells

31 March 2020

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Indirect allorecognition in acquired thymic tolerance: induction of donor-specific permanent acceptance of rat islets by adoptive transfer of allopeptide-pulsed host myeloid and thymic dendritic cells.

31 March 2020

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Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survival

31 March 2020

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Prolongation of heart allograft survival by immature dendritic cells generated from recipient type bone marrow progenitors.

31 March 2020

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Donor-specific allograft tolerance by administration of recipient-derived immature dendritic cells and suboptimal immunosuppression

31 March 2020

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Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse

31 March 2020

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In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance

31 March 2020

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Induction of allopeptide-specific human CD4+CD25+ regulatory T cells ex vivo.

31 March 2020

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Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells

31 March 2020

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Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts.

31 March 2020

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A minor population of splenic dendritic cells expressing CD19 mediates IDO-dependent T cell suppression via type I IFN signaling following B7 ligation

31 March 2020

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Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase

31 March 2020

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Cutting edge: CpG oligonucleotides induce splenic CD19+ dendritic cells to acquire potent indoleamine 2,3-dioxygenase-dependent T cell regulatory functions via IFN Type 1 signaling

31 March 2020

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Modified dendritic cells coexpressing self and allogeneic major histocompatability complex molecules: an efficient way to induce indirect pathway regulation

31 March 2020

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Targeted lymphoid homing of dendritic cells is required for prolongation of allograft survival

31 March 2020

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Immunosuppressive properties of CD95L-transduced "killer" hybrids created by fusing donor- and recipient-derived dendritic cells

31 March 2020

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The immune regulatory effect of apoptotic cells and exosomes on dendritic cells: its impact on transplantation

31 March 2020

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Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo

31 March 2020

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Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance

31 March 2020

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Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production.

31 March 2020

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Use of the inhibitory effect of apoptotic cells on dendritic cells for graft survival via T-cell deletion and regulatory T cells

31 March 2020

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Exosomes: composition, biogenesis and function

31 March 2020

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Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells

31 March 2020

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Induction of Tolerance by Exosomes and Short-Term Immunosuppression in a Fully MHC-Mismatched Rat Cardiac Allograft Model

31 March 2020

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Hepatic T cells and liver tolerance

31 March 2020

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GM-CSF expands dendritic cells and their progenitors in mouse liver

31 March 2020

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Deletion of spontaneous rat liver allograft acceptance by donor irradiation

31 March 2020

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Growth of donor-derived dendritic cells from the bone marrow of murine liver allograft recipients in response to granulocyte/macrophage colony-stimulating factor

31 March 2020

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Evidence that apoptosis of activated T cells occurs in spontaneous tolerance of liver allografts and is blocked by manipulations which break tolerance

31 March 2020

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Il-12 antagonism enhances apoptotic death of T cells within hepatic allografts from Flt3 ligand-treated donors and promotes graft acceptance

31 March 2020

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Mechanism of endotoxin desensitization: involvement of interleukin 10 and transforming growth factor beta

31 March 2020

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Toll receptors, CD14, and macrophage activation and deactivation by LPS.

31 March 2020

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IRAK-M is a negative regulator of Toll-like receptor signaling

31 March 2020

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Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells

31 March 2020

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SOCS-1 participates in negative regulation of LPS responses

31 March 2020

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IL-12 Suppression During Experimental Endotoxin Tolerance: Dendritic Cell Loss and Macrophage Hyporesponsiveness

31 March 2020

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Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells

31 March 2020

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Low TLR4 expression by liver dendritic cells correlates with reduced capacity to activate allogeneic T cells in response to endotoxin

31 March 2020

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Endotoxin modulates the capacity of CpG-activated liver myeloid DC to direct Th1-type responses

31 March 2020

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Induction of endotoxin tolerance inhibits alloimmune responses.

31 March 2020

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Negative regulation of toll-like receptor-mediated immune responses

31 March 2020

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Identifiers

DOI

10.1038/NRI2132

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16 August 2017

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PubMed ID

17627284