First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy. (Q36890491)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22719020%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy (English)

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5 February 2020

2

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5 February 2020

Robert L Ferris

5

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5 February 2020

Simion Chiosea

19

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5 February 2020

Naftali Kaminski

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Malabika Sen

1 reference

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5 February 2020

Jennifer Rubin Grandis

26

object named as

Jennifer R Grandis

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Jonas T Johnson

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Seungwon Kim

1 reference

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Sonali Joyce

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Umamaheswar Duvvuri

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Raja R Seethala

1 reference

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5 February 2020

author name string

Joanne I Yeh

4

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5 February 2020

Jessica Lee

8

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5 February 2020

Nivedita Sahu

9

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Maria L Freilino

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5 February 2020

Haibin Shi

12

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5 February 2020

Changyou Li

13

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5 February 2020

Danith Ly

14

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5 February 2020

Srinivas Rapireddy

15

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5 February 2020

Jonathan P Etter

16

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5 February 2020

Pui-Kai Li

17

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5 February 2020

Lin Wang

18

1 reference

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5 February 2020

William E Gooding

21

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5 February 2020

Xiaomin Chen

22

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5 February 2020

Kusum Pandit

24

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5 February 2020

Daniel E Johnson

25

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5 February 2020

publication date

20 June 2012

1 reference

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5 February 2020

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5 February 2020

volume

2

1 reference

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5 February 2020

issue

8

1 reference

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5 February 2020

page(s)

694-705

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STAT3 activation in monocytes accelerates liver cancer progression

5 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3

29 September 2017

1 reference

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Down-regulation of STAT3 expression by vector-based small interfering RNA inhibits pancreatic cancer growth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

Stat3 orchestrates tumor development and progression: the Achilles' heel of head and neck cancers?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

Expression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinoma.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

Inhibitory effects of decoy-ODN targeting activated STAT3 on human glioma growth in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

Phase 0 clinical trial of the poly (ADP-ribose) polymerase inhibitor ABT-888 in patients with advanced malignancies

29 September 2017

1 reference

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Intratumoral epidermal growth factor receptor antisense DNA therapy in head and neck cancer: first human application and potential antitumor mechanisms

29 September 2017

1 reference

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Signal transducer and activator of transcription 3 activation is associated with bladder cancer cell growth and survival

29 September 2017

1 reference

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Brachyury, SOX-9, and podoplanin, new markers in the skull base chordoma vs chondrosarcoma differential: a tissue microarray-based comparative analysis

29 September 2017

1 reference

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Lack of toxicity of a STAT3 decoy oligonucleotide.

29 September 2017

1 reference

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Overview of Biacore systems and their applications

29 September 2017

1 reference

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Therapeutic effects of STAT3 decoy oligodeoxynucleotide on human lung cancer in xenograft mice

29 September 2017

1 reference

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Increase in nuclease resistance and incorporation of NF-kappaB decoy oligodeoxynucleotides by modification of the 3'-terminus

29 September 2017

1 reference

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Transcription factor decoy oligonucleotide-based therapeutic strategy for renal disease

29 September 2017

1 reference

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STAT3 as a central mediator of neoplastic cellular transformation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

Touched and moved by STAT3.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

STAT3 as a therapeutic target in head and neck cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

Targeting transcription factors for cancer gene therapy.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

Malignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

Transcription factor decoy oligonucleotides modified with locked nucleic acids: an in vitro study to reconcile biostability with binding affinity.

29 September 2017

1 reference

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The STATs of cancer--new molecular targets come of age

29 September 2017

1 reference

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Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth

29 September 2017

1 reference

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Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

29 September 2017

1 reference

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Use of minimally modified antisense oligonucleotides for specific inhibition of gene expression

29 September 2017

1 reference

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Ex-vivo gene therapy of human vascular bypass grafts with E2F decoy: the PREVENT single-centre, randomised, controlled trial

29 September 2017

1 reference

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Expression of a tyrosine phosphorylated, DNA binding Stat3beta dimer in bacteria

29 September 2017

1 reference

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Three-dimensional structure of the Stat3beta homodimer bound to DNA

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

29 September 2017

1 reference

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Biodistribution and metabolism of internally 3H-labeled oligonucleotides. II. 3',5'-blocked oligonucleotides

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

Transcription factor decoy for AP-1 reduces mesangial cell proliferation and extracellular matrix production in vitro and in vivo

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

Application of transcription factor "decoy" strategy as means of gene therapy and study of gene expression in cardiovascular disease

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668699

Validating Stat3 in cancer therapy

4 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22719020

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Using Biacore to measure the binding kinetics of an antibody-antigen interaction

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22719020

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Targeting STAT3 in cancer: how successful are we?

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22719020

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/2159-8290.CD-12-0191

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22719020%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22719020%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference