Targeting STAT3 in cancer: how successful are we? (Q82824786)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19053881%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

review article

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title

Targeting STAT3 in cancer: how successful are we? (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19053881%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

author name string

Peibin Yue

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19053881%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

James Turkson

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19053881%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

publication date

1 January 2009

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Expert Opinion on Investigational Drugs

17 January 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19053881%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

18

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17 January 2020

issue

1

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17 January 2020

page(s)

45-56

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Preassociation of nonactivated STAT3 molecules demonstrated in living cells using bioluminescence resonance energy transfer: a new model of STAT activation?

17 January 2020

cites work

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12 December 2020

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice

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12 December 2020

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

1 reference

12 December 2020

Preclinical studies of TW-37, a new nonpeptidic small-molecule inhibitor of Bcl-2, in diffuse large cell lymphoma xenograft model reveal drug action on both Bcl-2 and Mcl-1.

1 reference

12 December 2020

TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations

1 reference

12 December 2020

Monomeric recombinant peptide aptamers are required for efficient intracellular uptake and target inhibition

1 reference

12 December 2020

Transcription Factors as Molecular Targets: Molecular Mechanisms of Decoy ODN and their Design

1 reference

12 December 2020

Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution

1 reference

12 December 2020

In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy.

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12 December 2020

STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3.

1 reference

12 December 2020

JSI-124 inhibits glioblastoma multiforme cell proliferation through G(2)/M cell cycle arrest and apoptosis augment

1 reference

12 December 2020

Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway

1 reference

12 December 2020

Validating Stat3 in cancer therapy

1 reference

12 December 2020

Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer

1 reference

12 December 2020

Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells

1 reference

12 December 2020

Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes

1 reference

12 December 2020

An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects

1 reference

12 December 2020

Growth inhibition of human hepatocellular carcinoma cells by blocking STAT3 activation with decoy-ODN.

1 reference

12 December 2020

Transcription factor oligodeoxynucleotides to NF-kappaB inhibit transcription of IL-8 in bronchial cells

1 reference

12 December 2020

Design, synthesis, and studies of small molecule STAT3 inhibitors

1 reference

12 December 2020

A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells

1 reference

12 December 2020

Decoy oligodeoxynucleotide targeting activator protein-1 (AP-1) attenuates intestinal inflammation in murine experimental colitis

1 reference

12 December 2020

Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity.

1 reference

12 December 2020

Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells

1 reference

12 December 2020

Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells

1 reference

12 December 2020

Indirubin-3'-monoxime, a derivative of a Chinese anti-leukemia medicine, inhibits Notch1 signaling

1 reference

12 December 2020

Computational study on mechanism of G-quartet oligonucleotide T40214 selectively targeting Stat3.

1 reference

12 December 2020

Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target

1 reference

12 December 2020

Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(-)-gossypol] against diffuse large cell lymphoma

1 reference

12 December 2020

Therapeutic effects of STAT3 decoy oligodeoxynucleotide on human lung cancer in xenograft mice

1 reference

12 December 2020

Targeting Bcl-2 and Bcl-X with nonpeptidic small-molecule antagonists

1 reference

12 December 2020

Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

1 reference

12 December 2020

Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction

1 reference

12 December 2020

Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer

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12 December 2020

Does gene therapy become pharmacotherapy?

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12 December 2020

Identification of a high-affinity phosphopeptide inhibitor of Stat3.

1 reference

12 December 2020

G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis

1 reference

12 December 2020

Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes

1 reference

12 December 2020

Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth

1 reference

12 December 2020

Cucurbitacin I inhibits Stat3 and induces apoptosis in Sézary cells

1 reference

12 December 2020

Inhibition of normal lymphocyte proliferation by Indirubin-3'-monoxime: a multifactorial process

1 reference

12 December 2020

STAT3 as a target for inducing apoptosis in solid and hematological tumors

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12 December 2020

Three-dimensional structure of the Stat3beta homodimer bound to DNA

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12 December 2020

Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells

1 reference

12 December 2020

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity

1 reference

12 December 2020

JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells.

1 reference

12 December 2020

Selective inactivation of NF-kappaB in the liver using NF-kappaB decoy suppresses CCl4-induced liver injury and fibrosis

1 reference

12 December 2020

Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice

1 reference

12 December 2020

Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer

1 reference

12 December 2020

Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines

1 reference

12 December 2020

Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3.

1 reference

12 December 2020

The STATs of cancer--new molecular targets come of age

1 reference

12 December 2020

Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells

1 reference

12 December 2020

Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor

1 reference

12 December 2020

STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells

1 reference

12 December 2020

WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells

1 reference

12 December 2020

Growth inhibitory activity of cucurbitacin glucosides isolated from Citrullus colocynthis on human breast cancer cells

1 reference

12 December 2020

Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

1 reference

12 December 2020

STAT proteins as novel targets for cancer drug discovery

1 reference

12 December 2020

Inhibition of Stat3 activation and tumor growth suppression of non-small cell lung cancer by G-quartet oligonucleotides.

1 reference

12 December 2020

Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells.

1 reference

12 December 2020

Discovery of the catechol structural moiety as a Stat3 SH2 domain inhibitor by virtual screening

1 reference

12 December 2020

Inhibition of interleukin-6 signaling by galiellalactone

1 reference

12 December 2020

Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells

1 reference

12 December 2020

Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein

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12 December 2020

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

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12 December 2020

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

1 reference

12 December 2020

1 reference

12 December 2020

Paradigm shifts in the cell biology of STAT signaling

1 reference

12 December 2020

Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

1 reference

12 December 2020

STATs and gene regulation

1 reference

12 December 2020

Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity.

1 reference

12 December 2020

The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells

1 reference

12 December 2020

A new small-molecule Stat3 inhibitor

1 reference

12 December 2020

Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein

1 reference

12 December 2020

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

1 reference

12 December 2020

Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

1 reference

12 December 2020

Down-regulation of signal transducer and activator of transcription 3 expression using vector-based small interfering RNAs suppresses growth of human prostate tumor in vivo

1 reference

12 December 2020

Stat3 as a potential target for cancer immunotherapy.

1 reference

12 December 2020

A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo

1 reference

12 December 2020

10.1517/13543780802565791

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19053881%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19053881%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

19053881

1 reference