Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bioavailability of rats and humans (Q36909306)

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scientific article published on August 2007

Language	Label	Description	Also known as
English	Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bioavailability of rats and humans	scientific article published on August 2007

Statements

scholarly article

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bioavailability of rats and humans (English)

1 reference

Europe PubMed Central

17 August 2017

bioavailability

1 reference

based on heuristic

inferred from title

author name string

Susan Hurst

1

1 reference

Europe PubMed Central

17 August 2017

Cho-Ming Loi

2

1 reference

Europe PubMed Central

17 August 2017

Joanne Brodfuehrer

3

1 reference

Europe PubMed Central

17 August 2017

Ayman El-Kattan

4

1 reference

Europe PubMed Central

17 August 2017

language of work or name

0 references

publication date

1 August 2007

1 reference

Europe PubMed Central

17 August 2017

Expert Opinion on Drug Metabolism & Toxicology

1 reference

Europe PubMed Central

17 August 2017

3

1 reference

Europe PubMed Central

17 August 2017

4

1 reference

Europe PubMed Central

17 August 2017

469-489

1 reference

Europe PubMed Central

17 August 2017

The road map to oral bioavailability: an industrial perspective

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Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.

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Clinical Pharmacokinetics in Veterinary Medicine

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Physicochemical profiling (solubility, permeability and charge state).

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Anatomical and physiological parameters affecting gastrointestinal absorption in humans and rats

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Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals

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Rate-limiting barriers to intestinal drug absorption: a review

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Effect of 'unstirred' water layer in the intestine on the rate and extent of absorption after oral administration.

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Gastrointestinal transit and drug absorption

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Applying the biopharmaceutics classification system to veterinary pharmaceutical products. Part II. Physiological considerations

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Stress effects on gastrointestinal transit in the rat.

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Physiochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH.

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Role of intestinal bacteria in nutrient metabolism

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Transformation of flavonoids by intestinal microorganisms.

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Intestinal cholesterol metabolism

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In vivo and in vitro models of the human colonic flora

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The lymph lipid precursor pool is a key determinant of intestinal lymphatic drug transport.

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Bile increases intestinal lymphatic drug transport in the fasted rat.

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Animal models for the study of intestinal lymphatic drug transport

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Does fluid flow across the intestinal mucosa affect quantitative oral drug absorption? Is it time for a reevaluation?

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Paracellular drug transport across intestinal epithelia: influence of charge and induced water flux.

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Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides

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Physicochemical profiling in drug research: a brief survey of the state-of-the-art of experimental techniques

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Drug-like properties and the causes of poor solubility and poor permeability

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Intestinal drug transporters: in vivo function and clinical importance.

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Drug delivery to the small intestine

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Intestinal absorption of drugs mediated by drug transporters: mechanisms and regulation

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Improved intestinal transport of PD 158473, an N-methyl-D-aspartate (NMDA) antagonist, by involvement of multiple transporters

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The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?

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Species-dependent and site-specific intestinal metabolism of ester prodrugs

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Identifiers

10.1517/17425255.3.4.469

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

17 August 2017

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