Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms (Q36914895)

17 August 2017

Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms (English)

1 reference

17 August 2017

Smoothened Dmel_CG11561

1 reference

GOA release 2020-03-11

Hedgehog Dmel_CG4637

1 reference

GOA release 2020-03-11

3

Manuel Ascano

1 reference

17 August 2017

Stacey K Ogden

1

1 reference

17 August 2017

David J Casso

2

1 reference

17 August 2017

Mark M Yore

4

1 reference

17 August 2017

Thomas B Kornberg

5

1 reference

17 August 2017

David J Robbins

6

1 reference

17 August 2017

language of work or name

English

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publication date

19 January 2006

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Journal of Biological Chemistry

17 August 2017

7

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based on heuristic

inferred from page(s)

published in

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17 August 2017

281

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17 August 2017

11

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17 August 2017

7237-7243

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Communicating with Hedgehogs

17 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

Extensive phosphorylation of Smoothened in Hedgehog pathway activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

An intramolecular association between two domains of the protein kinase Fused is necessary for Hedgehog signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

Patterns in evolution: veins of the Drosophila wing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

Regulation of Hedgehog signaling: a complex story

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

Hedgehog signaling in animal development: paradigms and principles

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

A leptomycin B-sensitive homologue of human CRM1 promotes nuclear export of nuclear export sequence-containing proteins in Drosophila cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

Transposition of cloned P elements into Drosophila germ line chromosomes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

The fu gene discriminates between pathways to control dpp expression in Drosophila imaginal discs.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator

27 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510169200

Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510169200

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510169200

Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510169200

Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510169200

Hedgehog signal transduction in the posterior compartment of the Drosophila wing imaginal disc

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510169200

Identification of a tetrameric hedgehog signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510169200

Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510169200

Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510169200

Smoothened translates Hedgehog levels into distinct responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510169200

Making a better RNAi vector for Drosophila: use of intron spacers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510169200

Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510169200

Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M510169200

Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3677211

4 September 2018

Identifiers

DOI

10.1074/JBC.M510169200

1 reference

17 August 2017

1 reference

17 August 2017

PubMed publication ID

16423832

1 reference