Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog (Q44605502)

4 December 2017

Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog (English)

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4 December 2017

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Smoothened Dmel_CG11561

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Patched Dmel_CG2411

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Costa Dmel_CG1708

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author name string

Laurent Ruel

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4 December 2017

Ralph Rodriguez

2

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4 December 2017

Armel Gallet

3

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4 December 2017

Laurence Lavenant-Staccini

4

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4 December 2017

Pascal P Thérond

5

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4 December 2017

1 October 2003

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4 December 2017

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4 December 2017

5

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4 December 2017

10

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4 December 2017

907-913

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https://scigraph.springernature.com/pub.10.1038/ncb1052

4 December 2017

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cites work

Hedgehog signaling in animal development: paradigms and principles

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The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation

21 January 2018

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Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

21 January 2018

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Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus.

21 January 2018

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Role of the Drosophila patched gene in positional signalling

21 January 2018

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Biochemical evidence that patched is the Hedgehog receptor

21 January 2018

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The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal

21 January 2018

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smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

21 January 2018

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Dual roles for patched in sequestering and transducing Hedgehog

21 January 2018

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Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

21 January 2018

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Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction

21 January 2018

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Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2.

21 January 2018

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Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway

21 January 2018

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Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus

21 January 2018

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Posttranscriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system

21 January 2018

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Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein.

21 January 2018

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Molecular organisation and expression pattern of the segment polarity gene fused of Drosophila melanogaster.

21 January 2018

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The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking

21 January 2018

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Smoothened translates Hedgehog levels into distinct responses.

21 January 2018

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Phosphorylation of the fused protein kinase in response to signaling from hedgehog

21 January 2018

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Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression

21 January 2018

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Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways.

21 January 2018

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Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility

21 January 2018

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armadillo, bazooka, and stardust are critical for early stages in formation of the zonula adherens and maintenance of the polarized blastoderm epithelium in Drosophila.

21 January 2018

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Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2.

21 January 2018

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Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.

21 January 2018

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Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein

21 January 2018

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Cholesterol modification of hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to hedgehog

21 January 2018

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Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation

21 January 2018

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Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1038/NCB1052

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4 December 2017

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