Adenoviral overexpression and small interfering RNA suppression demonstrate that plasminogen activator inhibitor-1 produces elevated collagen accumulation in normal and keloid fibroblasts (Q36943056)

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scientific article published on 02 October 2008

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English	Adenoviral overexpression and small interfering RNA suppression demonstrate that plasminogen activator inhibitor-1 produces elevated collagen accumulation in normal and keloid fibroblasts	scientific article published on 02 October 2008

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15 January 2020

Adenoviral overexpression and small interfering RNA suppression demonstrate that plasminogen activator inhibitor-1 produces elevated collagen accumulation in normal and keloid fibroblasts (English)

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15 January 2020

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15 January 2020

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Tai-Lan Tuan

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15 January 2020

Paul Hwu

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15 January 2020

Wendy Ho

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15 January 2020

Peter Yiu

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15 January 2020

Richard Chang

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15 January 2020

Annette Wysocki

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15 January 2020

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2 October 2008

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15 January 2020

The American Journal of Pathology

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15 January 2020

173

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15 January 2020

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15 January 2020

1311-1325

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15 January 2020

Gene profiling of keloid fibroblasts shows altered expression in multiple fibrosis-associated pathways.

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29 September 2017

PAI-1 - a potential therapeutic target in cancer

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29 September 2017

The plasminogen activation system in lung disease

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PAI-1 as a target in kidney disease

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29 September 2017

Structure-function relationships of plasminogen activator inhibitor-1 and its potential as a therapeutic agent

1 reference

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29 September 2017

PAI-1 antagonists: predictable indications and unconventional applications

1 reference

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29 September 2017

Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

1 reference

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29 September 2017

Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis

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29 September 2017

Keloid pathogenesis and treatment

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Targeted therapy comes of age in scleroderma

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29 September 2017

Fibrin-induced skin fibrosis in mice deficient in tissue plasminogen activator

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29 September 2017

Plasminogen activator inhibitor-1: a common denominator in obesity, diabetes and cardiovascular disease

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Insulin-like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition

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29 September 2017

Molecular and functional interdependence of the urokinase-type plasminogen activator system with integrins

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29 September 2017

A mutant, noninhibitory plasminogen activator inhibitor type 1 decreases matrix accumulation in experimental glomerulonephritis

1 reference

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29 September 2017

Plasminogen activator/plasmin system: a major player in wound healing?

1 reference

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29 September 2017

Increased Plasminogen Activator Inhibitor-1 in Keloid Fibroblasts May Account for their Elevated Collagen Accumulation in Fibrin Gel Cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570122

29 September 2017

Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins

1 reference

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29 September 2017

Plasminogen activator inhibitor 1 functions as a urokinase response modifier at the level of cell signaling and thereby promotes MCF-7 cell growth

1 reference

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29 September 2017

Regulation of cell adhesion by PAI-1.

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29 September 2017

Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase

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29 September 2017

Absence of integrin alpha1beta1 in the mouse causes loss of feedback regulation of collagen synthesis in normal and wounded dermis.

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29 September 2017

The molecular basis of keloid and hypertrophic scar formation

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29 September 2017

The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin

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29 September 2017

Morphological and immunochemical differences between keloid and hypertrophic scar

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29 September 2017

Altered steady-state ratio of type I/III procollagen mRNAs correlates with selectively increased type I procollagen biosynthesis in cultured keloid fibroblasts

1 reference

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29 September 2017

Reduced growth-factor requirement of keloid-derived fibroblasts may account for tumor growth

1 reference

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29 September 2017

Fibronectin is overproduced by keloid fibroblasts during abnormal wound healing

1 reference

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29 September 2017

Interactions between type 1 plasminogen activator inhibitor, extracellular matrix and vitronectin

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29 September 2017

Growth kinetics and collagen synthesis of normal skin, normal scar and keloid fibroblasts in vitro

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29 September 2017

Epithelial-mesenchymal interactions in keloid pathogenesis modulate vascular endothelial growth factor expression and secretion

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27 June 2018

Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars.

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27 June 2018

Fibroblast-specific Expression of a Kinase-deficient Type II Transforming Growth Factor β (TGFβ) Receptor Leads to Paradoxical Activation of TGFβ Signaling Pathways with Fibrosis in Transgenic Mice

1 reference

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27 June 2018

Reduced hyaluronan in keloid tissue and cultured keloid fibroblasts

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27 June 2018

Identification of multiple, differentially expressed messenger RNAs in dermal fibroblasts from patients with systemic sclerosis

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27 June 2018

In vitro fibroplasia: matrix contraction, cell growth, and collagen production of fibroblasts cultured in fibrin gels

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27 June 2018

Differential glucocorticoid regulation of collagen mRNAs in human dermal fibroblasts. Keloid-derived and fetal fibroblasts are refractory to down-regulation.

1 reference

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27 June 2018

Fibronectin and fibrinolysis are not required for fibrin gel contraction by human skin fibroblasts

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27 June 2018

A novel truncated TGF-beta receptor II downregulates collagen synthesis and TGF-beta I secretion of keloid fibroblasts

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4 September 2018

Identification of unique gene expression patterns within different lesional sites of keloids.

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4 September 2018

Plasminogen activation induced pericellular fibronectin proteolysis promotes fibroblast apoptosis

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4 September 2018

Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation.

1 reference

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4 September 2018

PAI-1 deficiency reduces liver fibrosis after bile duct ligation in mice through activation of tPA.

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4 September 2018

Gene expression patterns in isolated keloid fibroblasts.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570122

4 September 2018

Smad3 signalling plays an important role in keloid pathogenesis via epithelial-mesenchymal interactions

1 reference

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4 September 2018

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1 reference

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4 September 2018

Both u-PA inhibition and vitronectin binding by plasminogen activator inhibitor 1 regulate HT1080 fibrosarcoma cell metastasis

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4 September 2018

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1 reference

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4 September 2018

Alterations in fibroblast alpha1beta1 integrin collagen receptor expression in keloids and hypertrophic scars

1 reference

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4 September 2018

Differential expression of transforming growth factor-beta receptors I and II and activation of Smad 3 in keloid fibroblasts

1 reference

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4 September 2018

The effect of TGF-beta on keloid fibroblast proliferation and collagen synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570122

4 September 2018

Elevated levels of plasminogen activator inhibitor-1 may account for the altered fibrinolysis by keloid fibroblasts.

1 reference

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4 September 2018

Hyaluronic acid metabolism in keloid fibroblasts

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4 September 2018

Alteration of amino acid transport by hydrocortisone. Different effects in human fibroblasts derived from normal skin and keloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical composition of the connective tissue in keloids and analysis of collagen metabolism in keloid fibroblast cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of mRNAs for type-1 plasminogen activator inhibitor, fibronectin, and type I procollagen by transforming growth factor-beta. Divergent responses in lung fibroblasts and carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of a plasminogen activator inhibitor 1 binding protein from human plasma. Identification as a multimeric form of S protein (vitronectin)

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Keloid fibroblasts are refractory to inhibition of DNA synthesis by phorbol esters. Altered response is accompanied by reduced sensitivity to prostaglandin E2 and altered down-regulation of phorbol ester binding sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibronectin gene transcription is enhanced in abnormal wound healing

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasminogen activation and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome scans provide evidence for keloid susceptibility loci on chromosomes 2q23 and 7p11

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of PAI-1 gene expression in human fibroblasts predisposed to a fibrotic phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temporal expression of urokinase plasminogen activator, plasminogen activator inhibitor and gelatinase-B in chronic wound fluid switches from a chronic to acute wound profile with progression to healing

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of transforming growth factor beta 1, 2, and 3 proteins in keloids

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Successful silencing of plasminogen activator inhibitor-1 in human vascular endothelial cells using small interfering RNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noninhibitory PAI-1 enhances plasmin-mediated matrix degradation both in vitro and in experimental nephritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor binding protein 5 induces skin fibrosis: A novel murine model for dermal fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional implications of the IL-6 signaling pathway in keloid pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2353/AJPATH.2008.080272

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Europe PubMed Central

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15 January 2020

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Europe PubMed Central

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15 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

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15 January 2020

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