Prediction of human pharmacokinetics--evaluation of methods for prediction of volume of distribution (Q36947315)

17 August 2017

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title

Prediction of human pharmacokinetics--evaluation of methods for prediction of volume of distribution (English)

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17 August 2017

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Urban Fagerholm

1

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17 August 2017

1 September 2007

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Journal of Pharmacy and Pharmacology

17 August 2017

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17 August 2017

59

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17 August 2017

1181-1190

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17 August 2017

9

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The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties.

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Prediction of in vivo tissue distribution from in vitro data. 3. Correlation between in vitro and in vivo tissue distribution of a homologous series of nine 5-n-alkyl-5-ethyl barbituric acids

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Volume of distribution at steady state for a linear pharmacokinetic system with peripheral elimination

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Prediction of the volume of distribution of a drug: which tissue-plasma partition coefficients are needed?

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Reduction and lumping of physiologically based pharmacokinetic models: prediction of the disposition of fentanyl and pethidine in humans by successively simplified models

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Prediction of drug disposition in infants and children by means of physiologically based pharmacokinetic (PBPK) modelling: theophylline and midazolam as model drugs

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Prediction of the disposition of midazolam in surgical patients by a physiologically based pharmacokinetic model

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In silico prediction of ADME and pharmacokinetics. Report of an expert meeting organised by COST B15.

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Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics.

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The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model

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Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance

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Prediction of human pharmacokinetics--gastrointestinal absorption

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Clinical pharmacokinetics of the cyclooxygenase inhibiting nitric oxide donator (CINOD) AZD3582.

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Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes

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Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics

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Prediction of brain delivery of ofloxacin, a new quinolone, in the human from animal data

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Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics

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A hybrid mixture discriminant analysis-random forest computational model for the prediction of volume of distribution of drugs in human.

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Interspecies scaling: a comparative study for the prediction of clearance and volume using two or more than two species

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Man versus beast: pharmacokinetic scaling in mammals

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Patterns of nonelectrolyte permeability in human red blood cell membrane

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Prediction of adipose tissue: plasma partition coefficients for structurally unrelated drugs

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Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution.

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Enterohepatic circulation: physiological, pharmacokinetic and clinical implications

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Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions.

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Tissue distribution of basic drugs: accounting for enantiomeric, compound and regional differences amongst beta-blocking drugs in rat.

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Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases.

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Prediction of the volumes of distribution of basic drugs in humans based on data from animals

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Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats

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Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method

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Ion-trapping, microsomal binding, and unbound drug distribution in the hepatic retention of basic drugs

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Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics

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A novel model for prediction of human drug clearance by allometric scaling

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Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection.

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Which in vitro screens guide the prediction of oral absorption and volume of distribution?

21 January 2018

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Prediction of human pharmacokinetics from animal data and molecular structural parameters using multivariate regression analysis: volume of distribution at steady state

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A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. II. Volume of distribution and mean residence time.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1211/JPP.59.9.0001

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17 August 2017

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PubMed ID

17883888