Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance (Q39805145)

14 September 2017

Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance (English)

1 reference

14 September 2017

1 reference

Urban Fagerholm

1

1 reference

14 September 2017

1 June 2007

1 reference

Journal of Pharmacy and Pharmacology

14 September 2017

1 reference

14 September 2017

59

1 reference

14 September 2017

803-828

1 reference

14 September 2017

6

1 reference

An evaluation of the in vitro metabolism data for predicting the clearance and drug-drug interaction potential of CYP2C9 substrates

14 September 2017

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

A compartmental model of hepatic disposition kinetics: 1. Model development and application to linear kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interconnected-tubes model of hepatic elimination: steady-state considerations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Predicting toxicokinetic parameters in humans from toxicokinetic data acquired from three small mammalian species

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of in vivo hepatic clearance from in vitro data using cryopreserved human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interspecies pharmacokinetic scaling of oltipraz in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Quantitative structure-metabolism relationship modeling of metabolic N-dealkylation reaction rates

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Clearance of fentanyl, alfentanil, methohexitone, thiopentone and ketamine in relation to estimated hepatic blood flow in several animal species: application to prediction of clearance in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Comparison of clearance predictions using primary cultures and suspensions of human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of hepatic clearance using cryopreserved human hepatocytes: a comparison of serum and serum-free incubations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prospective allometric scaling: does the emperor have clothes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

In silico prediction of ADME and pharmacokinetics. Report of an expert meeting organised by COST B15.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoin

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Early prediction of drug metabolism and toxicity: systems biology approach and modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

The current status of attempts to predict species differences in drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

The complexities of hepatic drug transport: current knowledge and emerging concepts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Comparison of oral absorption and bioavailablity of drugs between monkey and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Correlation of plasma clearance of 54 extensively metabolized drugs between humans and rats: mean allometric coefficient of 0.66.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Evaluation of using dog as an animal model to study the fraction of oral dose absorbed of 43 drugs in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Model based on GRID-derived descriptors for estimating CYP3A4 enzyme stability of potential drug candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

A commentary on the use of hepatocytes in drug metabolism studies during drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interspecies scaling of tebufelone pharmacokinetic data and application to preclinical toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Biological basis for extrapolation across mammalian species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Predictive ADMET studies, the challenges and the opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Comparison of in vitro preparations for semi-quantitative prediction of in vivo drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of whole-body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Effects of cell concentration on viability and metabolic activity during cryopreservation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Strategies and molecular probes to investigate the role of cytochrome P450 in drug metabolism: focus on in vitro studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

In silico approaches to predicting drug metabolism, toxicology and beyond.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

In silico ADME/Tox: the state of the art.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Progress in predicting human ADME parameters in silico

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Towards a new age of virtual ADME/TOX and multidimensional drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

In vitro and pharmacophore insights into CYP3A enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Quantitative structure activity relationships for the glucuronidation of simple phenols by expressed human UGT1A6 and UGT1A9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Influence of albumin on the distribution and elimination kinetics of diclofenac in the isolated perfused rat liver: analysis by the impulse-response technique and the dispersion model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Clinical pharmacokinetics of the cyclooxygenase inhibiting nitric oxide donator (CINOD) AZD3582.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Use of a cocktail of probe substrates for drug-metabolizing enzymes for the assessment of the metabolic capacity of hepatocyte preparations

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Utility of recombinant enzyme kinetics in prediction of human clearance: impact of variability, CYP3A5, and CYP2C19 on CYP3A4 probe substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interspecies scaling of cimetidine-theophylline pharmacokinetic interaction: interspecies scaling in pharmacokinetic interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Metabolic zonation of the liver: regulation and implications for liver function

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Impact of concentration and rate of intraluminal drug delivery on absorption and gut wall metabolism of verapamil in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Quantitative structure-pharmacokinetic relationships (QSPR) of beta blockers derived using neural networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Human hepatocytes as a tool for studying toxicity and drug metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Human hepatocytes in primary culture: the choice to investigate drug metabolism in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Uptake of a protein-bound polar compound, acetaminophen sulfate, by perfused rat liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interspecies scaling of clearance and volume of distribution for digoxin-specific Fab.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

The impact of in vitro binding on in vitro-in vivo extrapolations, projections of metabolic clearance and clinical drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Utility of rat liver slices to estimate hepatic clearance for application in physiologically based pharmacokinetic modeling: a study with tolbutamide, a compound with low extraction efficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Basal metabolic rates in mammals: taxonomic differences in the allometry of BMR and body mass.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Predicting the hepatic clearance of xenobiotics in humans from in vitro data

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Retention of transporter activities in cryopreserved, isolated rat hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Allometric scaling of xenobiotic clearance: uncertainty versus universality

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Hepatic structure-pharmacokinetic relationships: the hepatic disposition and metabolite kinetics of a homologous series of O-acyl derivatives of salicylic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Disposition kinetics of propranolol isomers in the perfused rat liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Feasibility of developing a neural network for prediction of human pharmacokinetic parameters from animal data

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

In vitro and in vivo assessment of hepatic and extrahepatic metabolism of diazepam in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interspecies scaling and comparisons in drug development and toxicokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Drug metabolism in hepatocyte sandwich cultures of rats and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Metabolic turnover rate: A physiological meaning of the metabolic rate per unit body weight

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Extended primary culture of human hepatocytes in a collagen gel sandwich system

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Extrapolation of experimental data from animals to man

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Extrapolation of diclofenac clearance from in vitro microsomal metabolism data: role of acyl glucuronidation and sequential oxidative metabolism of the acyl glucuronide

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interspecies pharmacokinetic scaling of metazosin, a novel alpha-adrenergic antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interspecies scaling of interferon disposition and comparison of allometric scaling with concentration-time transformations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interspecies scaling of tolcapone, a new inhibitor of catechol-O-methyltransferase (COMT). Use of in vitro data from hepatocytes to predict metabolic clearance in animals and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interspecies scaling of bosentan, a new endothelin receptor antagonist and integration of in vitro data into allometric scaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: application to 10 extensively metabolized drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interspecies pharmacokinetic comparisons and allometric scaling of napsagatran, a low molecular weight thrombin inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Erythrocytes as barriers for drug elimination in the isolated rat liver. II. Propranolol

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

A proposed blood circulation model for Reference Man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Modeling and allometric scaling of s(+)-ketoprofen pharmacokinetics and pharmacodynamics: a retrospective analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Use of allometry in predicting anatomical and physiological parameters of mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

The roles of transporters and enzymes in hepatic drug processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

In Silico ADME Prediction: Data, Models, Facts and Myths

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Physiologically Based Pharmacokinetic (PBPK) Modeling of Disposition of Epiroprim in Humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

In vitro human tissue models in risk assessment: report of a consensus-building workshop

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Integration of in vitro data and brain weight in allometric scaling to predict clearance in humans: some suggestions

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of clearance, volume of distribution and half-life by allometric scaling and by use of plasma concentrations predicted from pharmacokinetic constants: a comparative study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interspecies scaling: predicting oral clearance in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interspecies scaling of protein drugs: prediction of clearance from animals to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interspecies scaling: predicting pharmacokinetic parameters of antiepileptic drugs in humans from animals with special emphasis on clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interspecies scaling: a comparative study for the prediction of clearance and volume using two or more than two species

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interspecies scaling: predicting clearance of drugs in humans. Three different approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

The pharmacokinetic principles behind scaling from preclinical results to phase I protocols.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Metabolic stability for drug discovery and development: pharmacokinetic and biochemical challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Correlation of the intrinsic clearance of donepezil (Aricept) between in vivo and in vitro studies in rat, dog and human.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Structure-hepatic disposition relationships for phenolic compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Predictions of the in vivo clearance of drugs from rate of loss using human liver microsomes for phase I and phase II biotransformations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Pharmacokinetic scale-up: accurate prediction of human pharmacokinetic profiles from animal data

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Man versus beast: pharmacokinetic scaling in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interspecies scaling of clearance and volume of distribution data for five therapeutic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Pharmacokinetics and interspecies scaling of recombinant human factor VIII.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Utility of Hepatocytes in Predicting Drug Metabolism: Comparison of Hepatic Intrinsic Clearance in Rats and Humans in Vivo and in Vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Application of a Convective-Dispersion Model to Predict In Vivo Hepatic Clearance from In Vitro Measurements Utilizing Cryopreserved Human Hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Polar molecular surface properties predict the intestinal absorption of drugs in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Transport of propranolol and lidocaine through the rat blood-brain barrier. Primary role of globulin-bound drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Strategies for using in vitro screens in drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

First-pass elimination. Basic concepts and clinical consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of the disposition of propafenone in humans and dogs from pharmacokinetic parameters in other animal species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Allometric analysis of doxycycline pharmacokinetic parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

The allometric approach for interspecies scaling of pharmacokinetic parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

High-throughput screening approaches for investigating drug metabolism and pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

A dispersion model of hepatic elimination: 3. Application to metabolite formation and elimination kinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Residence time distributions of solutes in the perfused rat liver using a dispersion model of hepatic elimination: 1. Effect of changes in perfusate flow and albumin concentration on sucrose and taurocholate

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Clearance concepts in pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of the pharmacokinetic parameters of reduced-dolasetron in man using in vitro-in vivo and interspecies allometric scaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Models of hepatic drug elimination

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Experimental studies of transient mass transfer and reaction in the liver: interpretation with a heterogeneous compartment model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of the volumes of distribution of basic drugs in humans based on data from animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Interspecies pharmacokinetic scaling of DA-8159, a new erectogenic, in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Ion-trapping, microsomal binding, and unbound drug distribution in the hepatic retention of basic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Impaired glutathione-conjugating capacity by cryopreserved human and rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of aztreonam pharmacokinetics in humans based on data from animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

A novel model for prediction of human drug clearance by allometric scaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Modeling the in vitro intrinsic clearance of the slowly metabolized compound tolbutamide determined in sandwich-cultured rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential--toward a consensus

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Bosentan, a new endothelin receptor antagonist: prediction of the systemic plasma clearance in man from combined in vivo and in vitro data

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

ADMET in silico modelling: towards prediction paradise?

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Estimation of metabolic rate constants in PBPK-models from liver slice experiments: what are the experimental needs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Disposition of the selective alpha1A-adrenoceptor antagonist tamsulosin in humans: comparison with data from interspecies scaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Determination of in vivo absorption, metabolism, and transport of drugs by the human intestinal wall and liver with a novel perfusion technique.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of human clearance from animal data and molecular structural parameters using multivariate regression analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of Human Pharmacokinetics from Animal Data and Molecular Structural Parameters using Multivariate Regression Analysis: Oral Clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of human pharmacokinetic profile in animal scale up based on normalizing time course profiles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Species Differences in Microsomal Monooxygenase Activity and Their Relationship to Biological Half-Lives

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. I. Clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Dissociation from albumin: a potentially rate-limiting step in the clearance of substances by the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Collagen sandwich culture affects intracellular polyamine levels of human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

A general model for the origin of allometric scaling laws in biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Comparison of prediction methods for in vivo clearance of (S,S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride, a dopamine D2 receptor antagonist, in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Kinetics of diazepam metabolism in rat hepatic microsomes and hepatocytes and their use in predicting in vivo hepatic clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of hepatic metabolic clearance: comparison and assessment of prediction models

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

A Microassay for Measuring Cytochrome P450IA1 and Cytochrome P450IIB1 Activities in Intact Human and Rat Hepatocytes Cultured on 96-Well Plates

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.59.6.0007

21 January 2018

Identifiers

DOI

10.1211/JPP.59.6.0007

1 reference

14 September 2017

1 reference

PubMed ID

17637173