Focal adhesion kinase: a promising target for anticancer therapy (Q36956729)

17 August 2017

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title

Focal adhesion kinase: a promising target for anticancer therapy (English)

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17 August 2017

Nikolaos A Chatzizacharias

series ordinal

1

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17 August 2017

Gregory P Kouraklis

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2

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17 August 2017

Stamatios E Theocharis

series ordinal

3

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17 August 2017

language of work or name

English

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publication date

1 October 2007

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Expert Opinion on Therapeutic Targets

17 August 2017

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17 August 2017

11

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17 August 2017

10

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17 August 2017

1315-1328

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pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions

17 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Signaling through focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

21 January 2018

Focal adhesion kinase

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Focal adhesion kinase and associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

SHP-2 promoting migration and metastasis of MCF-7 with loss of E-cadherin, dephosphorylation of FAK and secretion of MMP-9 induced by IL-1beta in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Differential regulation of components of the focal adhesion complex by heregulin: role of phosphatase SHP-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

PTEN gene and integrin signaling in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Study of the PTEN gene expression and FAK phosphorylation in human hepatocarcinoma tissues and cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

New concepts regarding focal adhesion kinase promotion of cell migration and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Integrin alpha2-mediated ERK and calpain activation play a critical role in cell adhesion and motility via focal adhesion kinase signaling: identification of a novel signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Focal adhesion kinase, Rap1, and transcriptional induction of vascular endothelial growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Integrin-regulated FAK-Src signaling in normal and cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Role of focal adhesion kinase and phosphatidylinositol 3'-kinase in integrin fibronectin receptor-mediated, matrix metalloproteinase-1-dependent invasion by metastatic prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Focal adhesion kinase: a potential target in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Role of focal adhesion kinase in integrin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Focal adhesion kinase controls cellular levels of p27/Kip1 and p21/Cip1 through Skp2-dependent and -independent mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Focal adhesion kinase is activated in invading fibrosarcoma cells and regulates metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Focal adhesion kinase signaling and the aggressive melanoma phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Focal adhesion kinase promotes the aggressive melanoma phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Focal adhesion kinase is required for bombesin-induced prostate cancer cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Disruption of focal adhesion kinase slows transendothelial migration of AU-565 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Pressure activates colon cancer cell adhesion by inside-out focal adhesion complex and actin cytoskeletal signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

A role for focal adhesion kinase signaling in tumor necrosis factor-alpha-dependent matrix metalloproteinase-9 production in a cholangiocarcinoma cell line, CCKS1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

A role for focal adhesion kinase in hyluronan-dependent MMP-2 secretion in a human small-cell lung carcinoma cell line, QG90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Enhanced expression of cholecystokinin-2 receptor promotes the progression of colon cancer through activation of focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Gefitinib ('Iressa'), an epidermal growth factor receptor tyrosine kinase inhibitor, mediates the inhibition of lymph node metastasis in oral cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Focal adhesion kinase (FAK) phosphorylation is not required for genistein-induced FAK-beta-1-integrin complex formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Imatinib mesylate induces apoptosis in human cholangiocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Cellular characterization of a novel focal adhesion kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Mechanisms for the apoptosis of small cell lung cancer cells induced by anti-GD2 monoclonal antibodies: roles of anoikis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Mechanism of cell cycle regulation by FIP200 in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Identification of RB1CC1, a novel human gene that can induce RB1 in various human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Acquisition of chemoresistance following discontinuous exposures to cisplatin is associated in ovarian carcinoma cells with progressive alteration of FAK, ERK and p38 activation in response to treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Expression of focal adhesion kinase in acute myeloid leukemia is associated with enhanced blast migration, increased cellularity, and poor prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Caspase 3-mediated focal adhesion kinase processing in human ovarian cancer cells: possible regulation by X-linked inhibitor of apoptosis protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Focal adhesion kinase silencing augments docetaxel-mediated apoptosis in ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Focal adhesion kinase and protein kinase B cooperate to suppress doxorubicin-induced apoptosis of breast tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Antisense oligonucleodes targeting the focal adhesion kinase inhibit proliferation, induce apoptosis and cooperate with cytotoxic drugs in human glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Focal adhesion kinase affects the sensitivity of human hepatocellular carcinoma cell line SMMC-7721 to tumor necrosis factor-alpha/cycloheximide-induced apoptosis by regulating protein kinase B levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Ionizing radiation modules of the expression and tyrosine phosphorylation of the focal adhesion-associated proteins focal adhesion kinase (FAK) and its substrates p130cas and paxillin in A549 human lung carcinoma cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

p53 and Egr-1 additively suppress transformed growth in HT1080 cells but Egr-1 counteracts p53-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Increased expression of ICAM-3 is associated with radiation resistance in cervical cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Antiapoptotic action of focal adhesion kinase (FAK) against ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Role of c-Src and focal adhesion kinase in progression and metastasis of estrogen receptor-positive breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Src kinase promotes adhesion-independent activation of FAK and enhances cellular migration in tamoxifen-resistant breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Estrogen signaling via a linear pathway involving insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein kinase in MCF-7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Effects of PPARgamma agonists on cell survival and focal adhesions in a Chinese thyroid carcinoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

RRM1-induced metastasis suppression through PTEN-regulated pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast and lung tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1315

10.1517/14728222.11.10.1315

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference