c-Jun N-terminal kinases as potential therapeutic targets (Q36956736)

17 August 2017

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title

c-Jun N-terminal kinases as potential therapeutic targets (English)

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17 August 2017

Baljinder Salh

1

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17 August 2017

language of work or name

English

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publication date

1 October 2007

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Expert Opinion on Therapeutic Targets

17 August 2017

published in

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17 August 2017

volume

11

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17 August 2017

issue

10

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17 August 2017

page(s)

1339-1353

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Initial sequencing and analysis of the human genome

17 August 2017

cites work

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https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Cell signaling by receptor tyrosine kinases

21 January 2018

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Toll-like receptors and innate immunity

21 January 2018

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Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

21 January 2018

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Signal transduction by the JNK group of MAP kinases

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Essential function for the kinase TAK1 in innate and adaptive immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

AP-1: a double-edged sword in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

MAP kinases in the immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Rotavirus activates JNK and p38 signaling pathways in intestinal cells, leading to AP-1-driven transcriptional responses and enhanced virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

c-Jun NH2-terminal kinase 2 is required for Ras transformation independently of activator protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Phosphoinositide-3 kinase-Rac1-c-Jun NH2-terminal kinase signaling mediates collagen I-induced cell scattering and up-regulation of N-cadherin expression in mouse mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

JNK regulates autocrine expression of TGF-beta1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

c-Jun N-terminal kinase is activated in non-small-cell lung cancer and promotes neoplastic transformation in human bronchial epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

c-Jun NH(2)-terminal kinase 2alpha2 promotes the tumorigenicity of human glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Inhibition of JNK activation through NF-kappaB target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

The epidemiology of inflammatory bowel disease in Canada: a population-based study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

The immunological and genetic basis of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

JNK1 but not JNK2 promotes the development of steatohepatitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

The isoform-specific functions of the c-Jun N-terminal Kinases (JNKs): differences revealed by gene targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

A critical role of neural-specific JNK3 for ischemic apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Proapoptotic Nix activates the JNK pathway by interacting with POSH and mediates death in a Parkinson disease model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Targeting JNK for therapeutic benefit: from junk to gold?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Inflammation and metabolic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

A central role for JNK in obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

c-Jun N-terminal kinase-dependent mechanisms in respiratory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen Species

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.10.1339

10.1517/14728222.11.10.1339

21 January 2018

Identifiers

DOI

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17 August 2017

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