Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification (Q36960882)

17 August 2017

Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification (English)

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17 August 2017

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Devin M Wolfe

1

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17 August 2017

Ju-Hyun Lee

2

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17 August 2017

Asok Kumar

3

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17 August 2017

Sooyeon Lee

4

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17 August 2017

Samantha J Orenstein

5

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17 August 2017

Ralph A Nixon

6

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17 August 2017

language of work or name

English

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publication date

1 June 2013

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European Journal of Neuroscience

17 August 2017

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17 August 2017

37

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17 August 2017

1949-1961

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17 August 2017

12

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describes a project that uses

17 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3694736/fullTextXML

inferred from PubMed Central ID database lookup

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Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

29 September 2017

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A dual function of V0-ATPase a1 provides an endolysosomal degradation mechanism in Drosophila melanogaster photoreceptors

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29 September 2017

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Autophagic dysfunction in mucolipidosis type IV patients

29 September 2017

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Autophagy fights disease through cellular self-digestion

29 September 2017

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Autophagy in the Pathogenesis of Disease

29 September 2017

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Autophagy, amyloidogenesis and Alzheimer disease

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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TRP-ML1 regulates lysosomal pH and acidic lysosomal lipid hydrolytic activity

29 September 2017

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29 September 2017

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Lysosomes in cell death

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29 September 2017

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29 September 2017

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Elevated lysosomal pH in neuronal ceroid lipofuscinoses (NCLs)

29 September 2017

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Autophagy as a regulated pathway of cellular degradation

29 September 2017

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Legionella pneumophila replication vacuoles mature into acidic, endocytic organelles

29 September 2017

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Probing the cathepsin D using a BODIPY FL-pepstatin A: applications in fluorescence polarization and microscopy

29 September 2017

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A novel acidotropic pH indicator and its potential application in labeling acidic organelles of live cells

29 September 2017

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Structure and chromosomal assignment of the human cathepsin K gene

29 September 2017

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Functional activation of the cystic fibrosis trafficking mutant delta F508-CFTR by overexpression

29 September 2017

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Disassembly and reassembly of the yeast vacuolar H(+)-ATPase in vivo

29 September 2017

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

29 September 2017

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Visualization of acidic organelles in intact cells by electron microscopy

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694736

29 September 2017

Functions of lysosomes

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Evidence for a conserved 95-120 kDa subunit associated with and essential for activity of V-ATPases

29 September 2017

1 reference

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Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus

29 September 2017

1 reference

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An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694736

Lysosomal pH and analysis of the counter ion pathways that support acidification

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694736

The pH of the digestive vacuole of Plasmodium falciparum is not associated with chloroquine resistance

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694736

pH-dependent regulation of lysosomal calcium in macrophages

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694736

Cytokines regulate proteolysis in major histocompatibility complex class II-dependent antigen presentation by dendritic cells

27 June 2018

1 reference

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Structural requirements of procathepsin D activation and maturation

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694736

Degradation of proteasomes by lysosomes in rat liver.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694736

Distinct neuropathologic phenotypes after disrupting the chloride transport proteins ClC-6 or ClC-7/Ostm1.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694736

The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694736

Photoconversion of Lysotracker Red to a green fluorescent molecule.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694736

Cathepsin E deficiency induces a novel form of lysosomal storage disorder showing the accumulation of lysosomal membrane sialoglycoproteins and the elevation of lysosomal pH in macrophages.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694736

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694736

Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694736

Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694736

H2O2-mediated damage to lysosomal membranes of J-774 cells.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3694736

Rat brain cathepsin L: characterization and differentiation from cathepsin B utilizing opioid peptides

4 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FEJN.12169

Isolation of autophagic vacuoles from rat liver: morphological and biochemical characterization

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FEJN.12169

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FEJN.12169

Laboratory animal welfare; U.S. government principles for the utilization and care of vertebrate animals used in testing, research and training; notice

21 January 2018

1 reference

12 December 2020

Acidification of vacuoles is required for autophagic degradation in the yeast, Saccharomyces cerevisiae

1 reference

12 December 2020

The relationship between autophagy and the intracellular degradation of asialoglycoproteins in cultured rat hepatocytes

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12 December 2020

Differential localization of vacuolar H+-ATPases containing a1, a2, a3, or a4 (ATP6V0A1-4) subunit isoforms along the nephron

1 reference

12 December 2020

Acid phosphatase and beta-glucuronidase activities in the livers from rats fed 4-dimethylaminoazobenzene

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12 December 2020

Identifiers

DOI

10.1111/EJN.12169

1 reference

17 August 2017

1 reference

17 August 2017

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