Prediction of human pharmacokinetics - renal metabolic and excretion clearance (Q36988426)

17 August 2017

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title

Prediction of human pharmacokinetics - renal metabolic and excretion clearance (English)

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17 August 2017

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Urban Fagerholm

1

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17 August 2017

1 November 2007

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Journal of Pharmacy and Pharmacology

17 August 2017

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17 August 2017

59

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17 August 2017

1463-1471

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17 August 2017

11

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Caco-2 monolayers in experimental and theoretical predictions of drug transport

17 August 2017

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Stereoselective pharmacokinetics of atenolol in the rat: influence of aging and of renal failure.

21 January 2018

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Prediction of the disposition of midazolam in surgical patients by a physiologically based pharmacokinetic model

21 January 2018

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Prediction of drug disposition in infants and children by means of physiologically based pharmacokinetic (PBPK) modelling: theophylline and midazolam as model drugs

21 January 2018

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Effects of gender on the pharmacokinetics of drugs secreted by the renal organic anions transport systems in the rat.

21 January 2018

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Mean hepatic transit time in the determination of mean absorption time

21 January 2018

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Comparison of oral absorption and bioavailablity of drugs between monkey and human

21 January 2018

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21 January 2018

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Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance

21 January 2018

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Prediction of human pharmacokinetics--evaluation of methods for prediction of volume of distribution

21 January 2018

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Prediction of human pharmacokinetics--improving microsome-based predictions of hepatic metabolic clearance

21 January 2018

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Jejunal permeability in humans in vivo and rats in situ: investigation of molecular size selectivity and solvent drag.

21 January 2018

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Transporters and drug therapy: implications for drug disposition and disease

21 January 2018

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In vitro and in vivo assessment of hepatic and extrahepatic metabolism of diazepam in the rat.

21 January 2018

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MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening

21 January 2018

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Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport

21 January 2018

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Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

21 January 2018

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Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

21 January 2018

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Renal interaction between itraconazole and cimetidine

21 January 2018

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An evaluation method for nonlinear local disposition in rat liver and kidney

21 January 2018

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Pharmacokinetics and pharmacodynamics of intravenous bumetanide in mutant Nagase analbuminemic rats: importance of globulin binding for the pharmacodynamic effects

21 January 2018

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Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations

21 January 2018

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Interspecies pharmacokinetic comparisons and allometric scaling of napsagatran, a low molecular weight thrombin inhibitor.

21 January 2018

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A proposed blood circulation model for Reference Man.

21 January 2018

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Pharmacokinetics of the M1-agonist talsaclidine in mouse, rat, rabbit and monkey, and extrapolation to man.

21 January 2018

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Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models.

21 January 2018

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Mechanisms and clinical implications of renal drug excretion

21 January 2018

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Metabolic stability for drug discovery and development: pharmacokinetic and biochemical challenges

21 January 2018

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Covalent and noncovalent protein binding of drugs: implications for hepatic clearance, storage, and cell-specific drug delivery

21 January 2018

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Extrahepatic glucuronidation of propofol in man: possible contribution of gut wall and kidney

21 January 2018

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A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes

21 January 2018

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Enterohepatic circulation: physiological, pharmacokinetic and clinical implications

21 January 2018

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Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats

21 January 2018

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Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method

21 January 2018

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Glucuronide and glucoside conjugation of mycophenolic acid by human liver, kidney and intestinal microsomes

21 January 2018

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Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs

21 January 2018

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Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics

21 January 2018

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In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance

21 January 2018

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Theoretical predictions of drug absorption in drug discovery and development

21 January 2018

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Species-specific uncertainty factors for compounds eliminated principally by renal excretion in humans

21 January 2018

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A physiological model for the estimation of the fraction dose absorbed in humans.

21 January 2018

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Correlating partitioning and caco-2 cell permeability of structurally diverse small molecular weight compounds.

21 January 2018

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Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1211/JPP.59.11.0002

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17 August 2017

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PubMed ID

17976256