Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology? (Q37014218)

17 August 2017

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title

Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology? (English)

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17 August 2017

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2

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17 August 2017

1

Shah Ebrahim

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PubMed ID

18038153

17 August 2017

language of work or name

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23 November 2007

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17 August 2017

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17 August 2017

123

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17 August 2017

15-33

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17 August 2017

1

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https://scigraph.springernature.com/pub.10.1007/s00439-007-0448-6

17 August 2017

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cites work

5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review

1 reference

https://api.crossref.org/works/10.1007%2FS00439-007-0448-6

Inflation in epidemiology: "the proof and measurement of association between two things" revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-007-0448-6

Fibrinogen, C-reactive protein and coronary heart disease: does Mendelian randomization suggest the associations are non-causal?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-007-0448-6

Alcohol consumption and mortality from all causes, coronary heart disease, and stroke: results from a prospective cohort study of scottish men with 21 years of follow up

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-007-0448-6

The role of genetic polymorphisms in environmental health

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-007-0448-6

Ancient genomes, wise bodies, unhealthy people: limits of a genetic paradigm in biology and medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-007-0448-6

Elevated plasma fibrinogen: cause or consequence of cardiovascular disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00439-007-0448-6

Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group

21 January 2018

1 reference

12 December 2020

Re: Estimation of Bias in Nongenetic Observational Studies Using “Mendelian Triangulation” by Bautista et al

1 reference

12 December 2020

Familial defective apolipoprotein B-100: a review, including some comparisons with familial hypercholesterolaemia

1 reference

12 December 2020

Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese patients

1 reference

12 December 2020

Hartnup disorder: unraveling the mystery

1 reference

12 December 2020

Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial

1 reference

12 December 2020

A cautionary note on the use of Mendelian randomization to infer causation in observational epidemiology

1 reference

12 December 2020

Fibrinogen and coronary heart disease: test of causality by 'Mendelian randomization'

1 reference

12 December 2020

An integrated approach to the meta-analysis of genetic association studies using Mendelian randomization

1 reference

12 December 2020

Milk, butter, and heart disease

1 reference

12 December 2020

Estimation of bias in nongenetic observational studies using "mendelian triangulation"

1 reference

12 December 2020

Colorectal cancer risk, chronic illnesses, operations, and medications: case control results from the Melbourne Colorectal Cancer Study.

1 reference

12 December 2020

Nutrient-gene interactions: the gene is not the disease and vice versa

1 reference

12 December 2020

Apolipoprotein E isoforms, serum cholesterol, and cancer.

1 reference

12 December 2020

Mendelian randomization: a new approach to studying epidemiology in ESRD.

1 reference

12 December 2020

Milk, coronary heart disease and mortality

1 reference

12 December 2020

Aspirin and nonsteroidal anti-inflammatory agents and risk for colorectal adenomas

1 reference

12 December 2020

Paraoxonase (PON1) polymorphisms in farmers attributing ill health to sheep dip.

1 reference

12 December 2020

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

1 reference

12 December 2020

A randomized trial of aspirin to prevent colorectal adenomas

1 reference

12 December 2020

Shattuck lecture--medical and societal consequences of the Human Genome Project.

1 reference

12 December 2020

Lactase deficiency: prevalence in osteoporosis

1 reference

12 December 2020

A new perspective on developmental plasticity and the principles of adaptive morph determination.

1 reference

12 December 2020

Do we need genomic research for the prevention of common diseases with environmental causes?

1 reference

12 December 2020

Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy: part II: the early evidence linking hypercholesterolemia to coronary disease in humans

1 reference

12 December 2020

Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fractures.

1 reference

12 December 2020

C-reactive protein and its role in metabolic syndrome: mendelian randomisation study

1 reference

12 December 2020

Osteoporosis, Intestinal Lactase Deficiency and Low Dietary Calcium Intake

1 reference

12 December 2020

Commentary: Mendelian randomization and gene-environment interaction

1 reference

12 December 2020

A COMPARISON OF GENETIC AND PHENOTYPIC CORRELATIONS.

1 reference

12 December 2020

Coronary Artery Disease in Combat Casualties in Vietnam

1 reference

12 December 2020

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

1 reference

12 December 2020

Variants in the CRP Gene as a Measure of Lifelong Differences in Average C-Reactive Protein Levels: The Cardiovascular Risk in Young Finns Study, 1980 2001

1 reference

12 December 2020

On the synthesis and interpretation of consistent but weak gene-disease associations in the era of genome-wide association studies

1 reference

12 December 2020

Biomedicine. Lowering LDL--not only how low, but how long?

1 reference

12 December 2020

Association between a specific apolipoprotein B mutation and familial defective apolipoprotein B-100

1 reference

12 December 2020

1 reference

12 December 2020

Genetic epidemiology and public health: hope, hype, and future prospects

1 reference

12 December 2020

Does lactose intolerance predispose to low bone density? A population-based study of perimenopausal Finnish women

1 reference

12 December 2020

Aldehyde dehydrogenase genotypes in Japanese alcoholics

1 reference

12 December 2020

A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer

1 reference

12 December 2020

The Hartnup phenotype: Mendelian transport disorder, multifactorial disease

1 reference

12 December 2020

Association of C-Reactive Protein With Blood Pressure and Hypertension

1 reference

12 December 2020

Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes

1 reference

12 December 2020

Folate, vitamin B6, and B12 intakes in relation to risk of stroke among men.

1 reference

12 December 2020

Capitalizing on Mendelian randomization to assess the effects of treatments.

1 reference

12 December 2020

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis

1 reference

12 December 2020

Neutral amino acid transport in epithelial cells and its malfunction in Hartnup disorder

1 reference

12 December 2020

Incubation period of coronary heart disease.

1 reference

12 December 2020

Genetic technologies and achieving health for populations

1 reference

12 December 2020

Alcohol and ADH2 in Israel: Ashkenazis, Sephardics, and recent Russian immigrants

1 reference

12 December 2020

Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy: part I

1 reference

12 December 2020

Alcohol consumption and risk of stroke: a meta-analysis

1 reference

12 December 2020

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

1 reference

12 December 2020

The use of common genetic polymorphisms to enhance the epidemiologic study of environmental carcinogens

1 reference

12 December 2020

Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia

1 reference

12 December 2020

The genetic contribution to the phenotype

1 reference

12 December 2020

Genetic epidemiological studies of coronary heart disease

1 reference

12 December 2020

A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia

1 reference

12 December 2020

Data dredging, bias, or confounding

1 reference

12 December 2020

MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial

1 reference

12 December 2020

Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology

1 reference

12 December 2020

Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation

1 reference

12 December 2020

Using genetically-defined rodent strains for the identification of hippocampal traits relevant for two-way avoidance behavior: a non-invasive approach

1 reference

12 December 2020

Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate?

1 reference

12 December 2020

Lactose intolerance associated with fractures of weight-bearing bones in Finnish women aged 38-57 years.

1 reference

12 December 2020

Concentration-affinity equivalence in gene regulation: convergence of genetic and environmental effects

1 reference

12 December 2020

Hypothesis: is low prenatal vitamin D a risk-modifying factor for schizophrenia?

1 reference

12 December 2020

Alcohol consumption and mortality among middle-aged and elderly U.S. adults

1 reference

12 December 2020

Genetically reduced antioxidative protection and increased ischemic heart disease risk: The Copenhagen City Heart Study.

1 reference

12 December 2020

Epidemiological methods for studying genes and environmental factors in complex diseases

1 reference

12 December 2020

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

1 reference

12 December 2020

Randomised by (your) god: robust inference from an observational study design

1 reference

12 December 2020

Insight into the nature of the CRP-coronary event association using Mendelian randomization.

1 reference

12 December 2020

Gene-environment interaction and aetiology of cancer: what does it mean and how can we measure it?

1 reference

12 December 2020

Alcohol and esophageal cancer, is there an exaggerated accusation?

1 reference

12 December 2020

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

1 reference

12 December 2020

Fibrinogen, social position, and "Mendelian randomisation".

1 reference

12 December 2020

The rise of neurogenetic determinism.

1 reference

12 December 2020

Limits to causal inference based on Mendelian randomization: a comparison with randomized controlled trials

1 reference

12 December 2020

Commentary: fibrinogen and coronary heart disease--test of causality by 'Mendelian' randomization by Keavney et al.

1 reference

12 December 2020

Shaking the tree: mapping complex disease genes with linkage disequilibrium

1 reference

12 December 2020

Does Elevated Plasma Fibrinogen Increase the Risk of Coronary Heart Disease?

1 reference

12 December 2020

Limitations of the Application of Fourfold Table Analysis to Hospital Data

1 reference

12 December 2020

Folate supplementation and cardiovascular disease

1 reference

12 December 2020

Familial defective apolipoprotein B-100: a single mutation that causes hypercholesterolemia and premature coronary artery disease

1 reference

12 December 2020

Dissociation of a phenotypic correlation: response to post-trial etherization and to variation in temporal distribution of practice trials.

1 reference

12 December 2020

Relation between average alcohol consumption and disease: an overview

1 reference

12 December 2020

Risk of fatal coronary heart disease in familial hypercholesterolaemia. Scientific Steering Committee on behalf of the Simon Broome Register Group

1 reference

12 December 2020

What can mendelian randomisation tell us about modifiable behavioural and environmental exposures?

1 reference

12 December 2020

Lactose intolerance and bone mass in postmenopausal Italian women

1 reference

12 December 2020

Commentary: Mendelian randomization--an update on its use to evaluate allogeneic stem cell transplantation in leukaemia

1 reference

12 December 2020

Genetic variation and willingness to participate in epidemiologic research: data from three studies

1 reference

12 December 2020

Cancer prevention and diet: help from single nucleotide polymorphisms

1 reference

12 December 2020

N-Acetyltransferase phenotype and risk in urinary bladder cancer: approaches in molecular epidemiology. Preliminary results in Sweden and Denmark

1 reference

12 December 2020

Putting the search for genes in perspective

1 reference

12 December 2020

Hereditary pellagra-like skin rash with temporary cerebellar ataxia, constant renal amino-aciduria, and other bizarre biochemical features

1 reference

12 December 2020

Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men.

1 reference

12 December 2020

Transgenic animals in integrative biology: approaches and interpretations of outcome

1 reference

12 December 2020

How to avoid bias when comparing bone marrow transplantation with chemotherapy

1 reference

12 December 2020

Risks of ischaemic heart-disease in familial hyperlipoproteinaemic states

1 reference

12 December 2020

Mendelian randomization: prospects, potentials, and limitations

1 reference

12 December 2020

Association of mutations in the apolipoprotein B gene with hypercholesterolemia and the risk of ischemic heart disease.

1 reference

12 December 2020

Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials

1 reference

12 December 2020

Nature's randomised trials

1 reference

12 December 2020

Folate intake and risk of stroke among women

1 reference

12 December 2020

Those confounded vitamins: what can we learn from the differences between observational versus randomised trial evidence?

1 reference

12 December 2020

Alcohol, ALDH2, and esophageal cancer: a meta-analysis which illustrates the potentials and limitations of a Mendelian randomization approach

1 reference

12 December 2020

Fifty years of medical genetics

1 reference

12 December 2020

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

1 reference

12 December 2020

Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group

1 reference

12 December 2020

10.1007/S00439-007-0448-6

Identifiers

DOI

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17 August 2017

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PubMed ID

18038153