Shaking the tree: mapping complex disease genes with linkage disequilibrium (Q36274243)

13 August 2017

Shaking the tree: mapping complex disease genes with linkage disequilibrium (English)

1 reference

13 August 2017

linkage disequilibrium

1 reference

1

1 reference

13 August 2017

Lon R Cardon

2

1 reference

PubMed ID

16198771

13 August 2017

language of work or name

English

0 references

publication date

1 October 2005

1 reference

13 August 2017

1 reference

13 August 2017

366

1 reference

13 August 2017

9492

1 reference

13 August 2017

1223-1234

1 reference

Genetic epidemiology and the future of disease prevention and public health

13 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Tailoring the genome: the power of genetic approaches

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Medicine. The NIH Roadmap

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Pharmacogenetics goes genomic

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Genomic Priorities and Public Health

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

The role of genetic polymorphisms in environmental health

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Locating gene–environment interaction: at the intersections of genetics and public health

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Searching for genetic determinants in the new millennium

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Single nucleotide polymorphisms and the future of genetic epidemiology

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Population stratification and spurious allelic association

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Gene-environment interactions--the BioBank UK study

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Association study designs for complex diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Genomics as a probe for disease biology

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Pharmacogenetics: potential for individualized drug therapy through genetics

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Massive parallelism, randomness and genomic advances

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Genomic empowerment: the importance of public databases

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Quality and completeness of SNP databases

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Nutrition and cancer: Background and rationale of the European Prospective Investigation into Cancer and Nutrition (EPIC)

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

The Million Women Study: design and characteristics of the study population. The Million Women Study Collaborative Group

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Genebanks: A Comparison of Eight Proposed International Genetic Databases

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Waiting for the working draft from the human genome project. A huge achievement, but not of immediate medical use.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

The International HapMap Project

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

The complex interplay among factors that influence allelic association.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Key concepts in genetic epidemiology

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Genetic association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Variation is the spice of life

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populations

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Haplotype variation and linkage disequilibrium in 313 human genes

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

New goals for the U.S. Human Genome Project: 1998-2003.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Using single nucleotide polymorphisms as a means to understanding the pathophysiology of asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

The use of a genetic map of biallelic markers in linkage studies

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Variations on a theme: cataloging human DNA sequence variation

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Identification of clusters of biallelic polymorphic sequence-tagged sites (pSTSs) that generate highly informative and automatable markers for genetic linkage mapping

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

It's raining SNPs, hallelujah?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Mapping genes that underlie ethnic differences in disease risk: methods for detecting linkage in admixed populations, by conditioning on parental admixture

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Evolution and distribution of (GT)n repetitive sequences in mammalian genomes

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

1 reference

7 January 2021

Single nucleotide polymorphisms as tools in human genetics

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Genetic epidemiology of single-nucleotide polymorphisms.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

A first-generation linkage disequilibrium map of human chromosome 22

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Polygenic disease: methods for mapping complex disease traits

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Patterns of linkage disequilibrium in the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

The future of genetic studies of complex human diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Data mining applied to linkage disequilibrium mapping

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Linkage disequilibrium and the mapping of complex human traits.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Susceptibility to leprosy is associated with PARK2 and PACRG.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Power of direct vs. indirect haplotyping in association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Relative efficiency of ambiguous vs. directly measured haplotype frequencies.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Bayesian haplotype inference for multiple linked single-nucleotide polymorphisms

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

A New Statistical Method for Haplotype Reconstruction from Population Data

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Score tests for association between traits and haplotypes when linkage phase is ambiguous

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Little loss of information due to unknown phase for fine-scale linkage-disequilibrium mapping with single-nucleotide-polymorphism genotype data.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

The fine-scale structure of recombination rate variation in the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

The impact of SNP density on fine-scale patterns of linkage disequilibrium

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Chromosome-wide distribution of haplotype blocks and the role of recombination hot spots

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Whole-genome patterns of common DNA variation in three human populations

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Haplotype tagging for the identification of common disease genes

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Genome scans and candidate gene approaches in the study of common diseases and variable drug responses

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Using haplotype blocks to map human complex trait loci

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Minimal haplotype tagging

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Efficient selective screening of haplotype tag SNPs

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Defining haplotype blocks and tag single-nucleotide polymorphisms in the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Haplotype block structure and its applications to association studies: power and study designs

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Some notes on the combinatorial properties of haplotype tagging.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Selection and evaluation of tagging SNPs in the neuronal-sodium-channel gene SCN1A: implications for linkage-disequilibrium gene mapping

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Efficiency and consistency of haplotype tagging of dense SNP maps in multiple samples.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Genetic mapping of complex traits

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Haplotype blocks and linkage disequilibrium in the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

How many diseases does it take to map a gene with SNPs?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Mapping of complex traits by single-nucleotide polymorphisms

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Genetic dissection of complex traits

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Molecular evolution meets the genomics revolution

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Principal component analysis for selection of optimal SNP-sets that capture intragenic genetic variation

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

High-resolution haplotype structure in the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

The structure of haplotype blocks in the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Prediction of survival and opportunistic infections in HIV-infected patients: a comparison of imputation methods of incomplete CD4 counts

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Assessing and interpreting treatment effects in longitudinal clinical trials with missing data

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

What do we do with missing data? Some options for analysis of incomplete data

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

A modelling strategy for the analysis of clinical trials with partly missing longitudinal data.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

On the relative sample size required for multiple comparisons

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Testing for candidate gene linkage disequilibrium using a dense array of single nucleotide polymorphisms in case-parents studies

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Case-control association studies for the genetics of complex respiratory diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Case-control association studies in pharmacogenetics

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Genomic approaches to understanding asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Race: a genetic melting-pot

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Categorization of humans in biomedical research: genes, race and disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Linkage disequilibrium patterns of the human genome across populations

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

The effects of human population structure on large genetic association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Assessing the impact of population stratification on genetic association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Major factors influencing linkage disequilibrium by analysis of different chromosome regions in distinct populations: demography, chromosome recombination frequency and selection

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Linkage disequilibrium and the search for complex disease genes

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Accounting for unmeasured population substructure in case-control studies of genetic association using a novel latent-class model

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Genomic control, a new approach to genetic-based association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Unbiased methods for population-based association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

A method for distinguishing consanguinity and population substructure using multilocus genotype data

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Association studies for quantitative traits in structured populations

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Use of unlinked genetic markers to detect population stratification in association studies.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Association mapping in structured populations

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Drug discovery in the next millennium

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Fulfilling the promise: drug discovery in the post-genomic era.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Population screening in the age of genomic medicine

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

An analysis of strategies for discovery of single-nucleotide polymorphisms

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Complex genetic diseases: controversy over the Croesus code

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Confounding, ascertainment bias, and the blind quest for a genetic 'fountain of youth'.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases I. DNA pooling

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Mutations and polymorphisms in the familial early-onset breast cancer (BRCA1) gene. Breast Cancer Information Core

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Linkage of early-onset familial breast cancer to chromosome 17q21

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Parameters for reliable results in genetic association studies in common disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Replication validity of genetic association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Candidate-gene approaches for studying complex genetic traits: practical considerations

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Large upward bias in estimation of locus-specific effects from genomewide scans

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

The genetic architecture of quantitative traits

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Domestic-animal genomics: deciphering the genetics of complex traits

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

The future is function

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Parallel genotyping of over 10,000 SNPs using a one-primer assay on a high-density oligonucleotide array

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

1 reference

7 January 2021

Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

The future of association studies: gene-based analysis and replication

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Genomics and medicine. Dissecting human disease in the postgenomic era.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Prospects for whole-genome linkage disequilibrium mapping of common disease genes

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

How many SNPs does a genome-wide haplotype map require?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Cost-effective analysis of candidate genes using htSNPs: a staged approach.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2967485-5

7 January 2021

10.1016/S0140-6736(05)67485-5

Identifiers

DOI

1 reference

13 August 2017

1 reference

PubMed ID

16198771