Hyperglycemia-induced protein kinase C β2 activation induces diastolic cardiac dysfunction in diabetic rats by impairing caveolin-3 expression and Akt/eNOS signaling. (Q37015027)

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scientific article published on 08 March 2013

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English	Hyperglycemia-induced protein kinase C β2 activation induces diastolic cardiac dysfunction in diabetic rats by impairing caveolin-3 expression and Akt/eNOS signaling.	scientific article published on 08 March 2013

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25 February 2020

Hyperglycemia-induced protein kinase C β2 activation induces diastolic cardiac dysfunction in diabetic rats by impairing caveolin-3 expression and Akt/eNOS signaling (English)

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Michael G. Irwin

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Shaoqing Lei

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Jinjin Xu

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Yanan Liu

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Xia Gao

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Kwok F J Ng

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Wayne Bond Lau

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Xin-Liang Ma

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Brian Rodrigues

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Zhengyuan Xia

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30 August 2021

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Caveolins and heart diseases

1 reference

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29 September 2017

Effects of N-acetylcysteine on nicotinamide dinucleotide phosphate oxidase activation and antioxidant status in heart, lung, liver and kidney in streptozotocin-induced diabetic rats

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29 September 2017

N-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats

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29 September 2017

Sildenafil and FDP-Sr attenuate diabetic cardiomyopathy by suppressing abnormal expression of myocardial CASQ2, FKBP12.6, and SERCA2a in rats

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29 September 2017

Left ventricular dysfunction in murine models of heart failure and in failing human heart is associated with a selective decrease in the expression of caveolin-3.

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29 September 2017

Intracavernous delivery of a designed angiopoietin-1 variant rescues erectile function by enhancing endothelial regeneration in the streptozotocin-induced diabetic mouse

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29 September 2017

Protein kinase C inhibitors in the treatment of diabetic retinopathy. Review

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Activation of protein kinase C isoforms and its impact on diabetic complications

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29 September 2017

Ruboxistaurin: PKC-beta inhibition for complications of diabetes

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29 September 2017

Diabetic cardiomyopathy--a distinct disease?

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29 September 2017

Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium

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29 September 2017

PKC inhibition and diabetic microvascular complications

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29 September 2017

NADPH oxidase-derived superoxide anion mediates angiotensin II-enhanced carotid body chemoreceptor sensitivity in heart failure rabbits

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29 September 2017

N-acetylcysteine attenuates PKCbeta2 overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats

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29 September 2017

Caveolin-3 inhibits growth signal in cardiac myoblasts in a Ca2+-dependent manner.

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29 September 2017

Caveolins and the regulation of endothelial nitric oxide synthase in the heart

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Caveolins: structure and function in signal transduction.

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Nitric oxide and the enigma of cardiac hypertrophy

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29 September 2017

Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade

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29 September 2017

The extended protein kinase C superfamily

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29 September 2017

The protective effect of thalidomide on left ventricular function in a rat model of diabetic cardiomyopathy

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27 June 2018

Selective inhibition of protein kinase C beta(2) attenuates inducible nitric oxide synthase-mediated cardiovascular abnormalities in streptozotocin-induced diabetic rats.

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27 June 2018

Niacin bound chromium treatment induces myocardial Glut-4 translocation and caveolar interaction via Akt, AMPK and eNOS phosphorylation in streptozotocin induced diabetic rats after ischemia-reperfusion injury

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27 June 2018

Study on the protective effect of shengmai san (see text) on the myocardium in the type 2 diabetic cardiomyopathy model rat.

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4 September 2018

PKCβ inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes.

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4 September 2018

Changes in caveolin-1 expression and vasoreactivity in the aorta and corpus cavernosum of fructose and streptozotocin-induced diabetic rats

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A PKC-beta inhibitor treatment reverses cardiac microvascular barrier dysfunction in diabetic rats

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Time-dependent regulation of muscle caveolin activation and insulin signalling in response to high-fat diet.

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4 September 2018

IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction

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4 September 2018

Increased expression of iNOS is associated with endothelial dysfunction and impaired pressor responsiveness in streptozotocin-induced diabetes.

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4 September 2018

Inactivation of 14-3-3 protein exacerbates cardiac hypertrophy and fibrosis through enhanced expression of protein kinase C beta 2 in experimental diabetes

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4 September 2018

Propofol dose-dependently reduces tumor necrosis factor-alpha-Induced human umbilical vein endothelial cell apoptosis: effects on Bcl-2 and Bax expression and nitric oxide generation

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Transgenic overexpression of insulin-like growth factor I prevents streptozotocin-induced cardiac contractile dysfunction and beta-adrenergic response in ventricular myocytes.

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4 September 2018

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4 September 2018

Inhibition of protein kinase C-beta by ruboxistaurin preserves cardiac function and reduces extracellular matrix production in diabetic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23474486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of NADPH oxidase alleviates experimental diabetes-induced myocardial contractile dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/23474486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High glucose-induced RhoA activation requires caveolae and PKCβ1-mediated ROS generation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23474486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23474486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23474486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23474486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of cyclodextrins for manipulating cellular cholesterol content

1 reference

https://pubmed.ncbi.nlm.nih.gov/23474486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-protein kinase C and hypertrophic signaling in human heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/23474486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated protein kinase C isoforms target to cardiomyocyte caveolae : stimulation of local protein phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23474486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/23474486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impairment of the vascular relaxation and differential expression of caveolin-1 of the aorta of diabetic +db/+db mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23474486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allopurinol attenuates left ventricular dysfunction in rats with early stages of streptozotocin-induced diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23474486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uncomplicated type 1 diabetes and preclinical left ventricular myocardial dysfunction: Insights from echocardiography and exercise cardiac performance evaluation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23474486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.2337/DB12-1391

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25 February 2020

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25 February 2020

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25 February 2020

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