The epidermal growth factor receptor system in skin repair and inflammation (Q37020092)

17 August 2017

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title

The epidermal growth factor receptor system in skin repair and inflammation (English)

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17 August 2017

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Saveria Pastore

1

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17 August 2017

Francesca Mascia

series ordinal

2

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17 August 2017

Valentina Mariani

series ordinal

3

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17 August 2017

Giampiero Girolomoni

series ordinal

4

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17 August 2017

language of work or name

English

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publication date

29 November 2007

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Journal of Investigative Dermatology

17 August 2017

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17 August 2017

128

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17 August 2017

6

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17 August 2017

1365-1374

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https://scigraph.springernature.com/pub.10.1038/sj.jid.5701184

17 August 2017

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Dermatologic side effects associated with the epidermal growth factor receptor inhibitors

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Role of tyrosine kinase inhibitors in cancer therapy

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Normal keratinocytes express Toll-like receptors (TLRs) 1, 2 and 5: modulation of TLR expression in chronic plaque psoriasis

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Cell migration is essential for sustained growth of keratinocyte colonies: the roles of transforming growth factor-alpha and epidermal growth factor

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7 January 2021

Inhibitors of tyrosine kinases in the treatment of psoriasis

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7 January 2021

Rac Activation upon Cell-Cell Contact Formation Is Dependent on Signaling from the Epidermal Growth Factor Receptor

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Amphiregulin and epidermal hyperplasia: amphiregulin is required to maintain the psoriatic phenotype of human skin grafts on severe combined immunodeficient mice

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7 January 2021

Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells

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7 January 2021

Enhancement of wound healing by topical treatment with epidermal growth factor

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7 January 2021

Integrin regulation of epidermal growth factor (EGF) receptor and of EGF-dependent responses

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7 January 2021

RhoB protects human keratinocytes from UVB-induced apoptosis through epidermal growth factor receptor signaling

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7 January 2021

The phosphoinositide 3-kinase pathway

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7 January 2021

Metalloprotease-dependent amphiregulin release mediates tumor necrosis factor-alpha-induced IL-8 secretion in the human airway epithelial cell line NCI-H292.

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7 January 2021

Production and auto-induction of transforming growth factor-α in human keratinocytes

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7 January 2021

Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitis

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7 January 2021

A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin

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7 January 2021

Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype

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https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor

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https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Overexpression of transforming growth factor alpha in psoriatic epidermis

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7 January 2021

Inflammation in wound repair: molecular and cellular mechanisms

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7 January 2021

ERK inhibitor PD98059 promotes the phenotypic and functional maturation of murine resident Langerhans cells

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7 January 2021

Wound healing is not impaired by the epidermal growth factor receptor-tyrosine kinase inhibitor gefitinib

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7 January 2021

Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission

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7 January 2021

Cutaneous side effects of epidermal growth factor receptor inhibitors: clinical presentation, pathogenesis, and management

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7 January 2021

Integrins: bidirectional, allosteric signaling machines

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7 January 2021

The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor

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Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway

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7 January 2021

The promise of molecular targeted therapies: protein kinase inhibitors in the treatment of cutaneous malignancies.

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7 January 2021

Mechanisms of cutaneous toxicities to EGFR inhibitors.

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7 January 2021

Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9

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7 January 2021

An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells

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7 January 2021

Signals that initiate, augment, and provide directionality for human keratinocyte motility

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7 January 2021

Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration.

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7 January 2021

Amphiregulin and nerve growth factor expression are regulated by barrier status in murine epidermis

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7 January 2021

The intracellular functions of alpha6beta4 integrin are regulated by EGF.

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7 January 2021

Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury

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7 January 2021

EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion

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7 January 2021

Inflammatory cells during wound repair: the good, the bad and the ugly

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https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Blockade of the EGF receptor induces a deranged chemokine expression in keratinocytes leading to enhanced skin inflammation

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7 January 2021

Regulation of cyclooxygenase-2 by interferon gamma and transforming growth factor alpha in normal human epidermal keratinocytes and squamous carcinoma cells. Role of mitogen-activated protein kinases

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7 January 2021

The role of toll-like receptors in the pathogenesis and treatment of dermatological disease

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https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Toll-like receptor expression in human keratinocytes: nuclear factor kappaB controlled gene activation by Staphylococcus aureus is toll-like receptor 2 but not toll-like receptor 4 or platelet activating factor receptor dependent.

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https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

TGF-alpha regulates TLR expression and function on epidermal keratinocytes

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https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

The epidermal growth factor receptor (EGFR): role in corneal wound healing and homeostasis

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https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Comparison of Epidermal Growth Factor Binding and Receptor Distribution in Normal Human Epidermis and Epidermal Appendages

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https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Altered [125I]epidermal growth factor binding and receptor distribution in psoriasis

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https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines

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https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Protein kinase inhibitors: insights into drug design from structure.

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7 January 2021

Alarmins: chemotactic activators of immune responses

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https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

ERK1/2 regulates epidermal chemokine expression and skin inflammation

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https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

HER1/EGFR inhibitor-associated rash: future directions for management and investigation outcomes from the HER1/EGFR inhibitor rash management forum

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https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Cutaneous adverse effects with HER1/EGFR-targeted agents: is there a silver lining?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

UVB-induced epidermal growth factor receptor phosphorylation is critical for downstream signaling and keratinocyte survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Overexpression of amphiregulin, a major autocrine growth factor for cultured human keratinocytes, in hyperproliferative skin diseases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Amphiregulin-dependent proliferation of cultured human keratinocytes: autocrine growth, the effects of exogenous recombinant cytokine, and apparent requirement for heparin-like glycosaminoglycans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Keratinocyte collagenase-1 expression requires an epidermal growth factor receptor autocrine mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Expression and function of Toll-like receptors 2 and 4 in human keratinocytes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Growth inhibition of psoriatic keratinocytes by quinazoline tyrosine kinase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

The beta 2-adrenergic receptor activates pro-migratory and pro-proliferative pathways in dermal fibroblasts via divergent mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Epidermal growth factor receptor activation under oxidative stress fails to promote c-Cbl mediated down-regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Organ-specific regulation of innate immunity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Response of psoriasis to interleukin-10 is associated with suppression of cutaneous type 1 inflammation, downregulation of the epidermal interleukin-8/CXCR2 pathway and normalization of keratinocyte maturation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

EGFR enhances early healing after cutaneous incisional wounding

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Linking integrin alpha6beta4-based cell adhesion to the intermediate filament cytoskeleton: direct interaction between the beta4 subunit and plectin at multiple molecular sites.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Modeling the cancer patient with genetically engineered mice: prediction of toxicity from molecule-targeted therapies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Expanding the roles of antimicrobial peptides in skin: alarming and arming keratinocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Cell signaling by receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Mammalian defensins in the antimicrobial immune response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Epiregulin, a member of the EGF family, is over-expressed in psoriatic epidermis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Dermatitis due to epiregulin deficiency and a critical role of epiregulin in immune-related responses of keratinocyte and macrophage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Anticancer therapy targeting the erbB family of receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Heparin-binding ligands mediate autocrine epidermal growth factor receptor activation In skin organ culture

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Retinoid regulation of heparin-binding EGF-like growth factor gene expression in human keratinocytes and skin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

The mechanism of cleavage of EGFR ligands induced by inflammatory cytokines in gastric cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide LL-37

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Interleukin-8 stimulates calcium transients and promotes epidermal cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Cytokine-induced expression of transforming growth factor-alpha and the epidermal growth factor receptor in neonatal skin explants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Heparin-binding epidermal-growth-factor-like growth factor activation of keratinocyte ErbB receptors Mediates epidermal hyperplasia, a prominent side-effect of retinoid therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Transactivation joins multiple tracks to the ERK/MAPK cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Inhibition of the epidermal growth factor receptor increases expression of genes that stimulate inflammation, apoptosis, and cell attachment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Receptor-type protein-tyrosine phosphatase-kappa regulates epidermal growth factor receptor function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Oxidative inhibition of receptor-type protein-tyrosine phosphatase kappa by ultraviolet irradiation activates epidermal growth factor receptor in human keratinocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

A novel function of angiotensin II in skin wound healing. Induction of fibroblast and keratinocyte migration by angiotensin II via heparin-binding epidermal growth factor (EGF)-like growth factor-mediated EGF receptor transactivation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Alteration and significance of heparin-binding epidermal-growth-factor-like growth factor in psoriatic epidermis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Exacerbation of psoriasis after treatment with an EGFR tyrosine kinase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5701184

7 January 2021

Identifiers

DOI

10.1038/SJ.JID.5701184

1 reference

Dimensions Publication ID

17 August 2017

0 references

1 reference