Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway. (Q37027667)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27328819%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

title

Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27328819%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

main subject

autophagy

0 references

alpha,alpha-trehalose

0 references

1 reference

4

1 reference

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14 March 2020

Mei Ju

6

1 reference

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14 March 2020

Heng Gu

9

1 reference

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14 March 2020

author name string

Xu Chen

1

1 reference

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14 March 2020

Min Li

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27328819%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Li Li

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27328819%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Dan Huang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27328819%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Ju Huang

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27328819%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Kun Chen

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27328819%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

language of work or name

English

0 references

publication date

22 June 2016

1 reference

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14 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27328819%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

volume

6

1 reference

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14 March 2020

page(s)

28423

1 reference

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Creative Commons Attribution 4.0 International

14 March 2020

copyright license

start time

22 June 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4916512/fullTextXML

inferred from PubMed Central ID database lookup

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The anti-tumor activator sMEK1 and paclitaxel additively decrease expression of HIF-1α and VEGF via mTORC1-S6K/4E-BP-dependent signaling pathways

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Trehalose alleviates PC12 neuronal death mediated by lipopolysaccharide-stimulated BV-2 cells via inhibiting nuclear transcription factor NF-κB and AP-1 activation

29 September 2017

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An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E⁻/⁻ mice

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MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis.

29 September 2017

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Resveratrol couples apoptosis with autophagy in UVB-irradiated HaCaT cells

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Autophagy proteins regulate ERK phosphorylation

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NF-κB activation was involved in reactive oxygen species-mediated apoptosis and autophagy in 1-oxoeudesm-11(13)-eno-12,8α-lactone-treated human lung cancer cells

29 September 2017

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Trehalose prevents neural tube defects by correcting maternal diabetes-suppressed autophagy and neurogenesis

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The nonstructural protein NP1 of human bocavirus 1 induces cell cycle arrest and apoptosis in Hela cells

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Microscopic mechanism of protein cryopreservation in an aqueous solution with trehalose

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29 September 2017

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29 September 2017

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Apigenin, a chemopreventive bioflavonoid, induces AMP-activated protein kinase activation in human keratinocytes.

29 September 2017

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29 September 2017

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29 September 2017

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Autophagy negatively regulates keratinocyte inflammatory responses via scaffolding protein p62/SQSTM1.

29 September 2017

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Enhanced contact allergen- and UVB-induced keratinocyte apoptosis in the absence of CD95/Fas/Apo-1

29 September 2017

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Autophagy during common bacterial and viral infections of children

29 September 2017

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Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1

29 September 2017

1 reference

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ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

29 September 2017

1 reference

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Autophagy induction by trehalose counteracts cellular prion infection

29 September 2017

1 reference

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Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

29 September 2017

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Autophagy fights disease through cellular self-digestion

29 September 2017

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Methods for monitoring autophagy from yeast to human

29 September 2017

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Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916512

Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916512

Toxic effects of ultraviolet radiation on the skin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916512

New insights on trehalose: a multifunctional molecule

29 September 2017

1 reference

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Specific effects of fructo- and gluco-oligosaccharides in the preservation of liposomes during drying

29 September 2017

1 reference

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A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles

29 September 2017

1 reference

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

29 September 2017

1 reference

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Epidermal differentiation: the bare essentials

29 September 2017

1 reference

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Trehalose transport and metabolism in Escherichia coli

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916512

mTOR regulates DNA damage response through NF-κB-mediated FANCD2 pathway in hematopoietic cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916512

Calcipotriol induces autophagy in HeLa cells and keratinocytes

27 June 2018

1 reference

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Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

27 June 2018

1 reference

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Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916512

Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease.

27 June 2018

1 reference

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Sucrose induces vesicle accumulation and autophagy.

4 September 2018

1 reference

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The significant role of autophagy in the granular layer in normal skin differentiation and hair growth.

4 September 2018

1 reference

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Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons

4 September 2018

1 reference

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The lysosomal signaling anchor p18/LAMTOR1 controls epidermal development by regulating lysosome-mediated catabolic processes.

4 September 2018

1 reference

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Epidermal keratinocytes form a functional skin barrier in the absence of Atg7 dependent autophagy.

4 September 2018

1 reference

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Targeted deletion of Atg5 reveals differential roles of autophagy in keratin K5-expressing epithelia.

4 September 2018

1 reference

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ATG16L1 gene polymorphisms are associated with palmoplantar pustulosis

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916512

LC3A-positive "stone-like" structures in cutaneous squamous cell carcinomas

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916512

Effects of tacrolimus on IFN-γ signaling in keratinocytes: possible mechanisms by which tacrolimus affects IFN-γ-dependent skin inflammation.

4 September 2018

1 reference

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Reduced UVB-induced corneal damage caused by reactive oxygen and nitrogen species and decreased changes in corneal optics after trehalose treatment

4 September 2018

1 reference

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Inhibition of mammalian target of rapamycin: the janus face of immunosuppression?

4 September 2018

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Sequestration assays for mammalian autophagy

4 September 2018

1 reference

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Candida albicans phospholipomannan triggers inflammatory responses of human keratinocytes through Toll-like receptor 2.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916512

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916512

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916512

Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916512

Inhibition of insulin amyloid formation by small stress molecules

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916512

Glucose effects on skin keratinocytes: implications for diabetes skin complications

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916512

Trehalose accumulation during cellular stress protects cells and cellular proteins from damage by oxygen radicals

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916512

Stroke after varicella and zoster ophthalmicus: another indication for treatment and immunization

4 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSREP28423

Association of UVRAG polymorphisms with susceptibility to non-segmental vitiligo in a Korean sample

21 January 2018

1 reference

12 December 2020

Inhibition of UVB-mediated oxidative stress and markers of photoaging in immortalized HaCaT keratinocytes by pomegranate polyphenol extract POMx

1 reference

12 December 2020

Polymorphisms in the ATG16L1 gene are associated with psoriasis vulgaris

1 reference

12 December 2020

β2-Adrenergic receptor-induced transactivation of epidermal growth factor receptor and platelet-derived growth factor receptor via Src kinase promotes rat cardiomyocyte survival

1 reference

12 December 2020

Mitochondria frozen with trehalose retain a number of biological functions and preserve outer membrane integrity

1 reference

12 December 2020

Use of [3H]raffinose as a specific probe of autophagic sequestration

1 reference

12 December 2020

Identifiers

DOI

10.1038/SREP28423

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27328819%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27328819%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

PubMed publication ID

27328819

1 reference