Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons (Q44193974)

30 November 2017

Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons (English)

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amyotrophic lateral sclerosis

30 November 2017

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alpha,alpha-trehalose

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2

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30 November 2017

8

Brigitte van Zundert

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30 November 2017

Karen Castillo

1

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30 November 2017

Vicente Valenzuela

3

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30 November 2017

Fabiola Rojas

4

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30 November 2017

Soledad Matus

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30 November 2017

Gabriela Mercado

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30 November 2017

Felipe A Court

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30 November 2017

Claudio Hetz

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30 November 2017

language of work or name

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6 June 2013

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30 November 2017

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30 November 2017

9

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30 November 2017

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30 November 2017

1308-1320

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Molecular biology of amyotrophic lateral sclerosis: insights from genetics

30 November 2017

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https://api.crossref.org/works/10.4161%2FAUTO.25188

ALS: a disease of motor neurons and their nonneuronal neighbors

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.25188

Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.25188

Amyotrophic lateral sclerosis pathogenesis: a journey through the secretory pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Protein misfolding disorders and macroautophagy

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.25188

Autophagy fights disease through cellular self-digestion

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.25188

Axonal ligation induces transient redistribution of TDP-43 in brainstem motor neurons

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.25188

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

In vivo optical imaging of motor neuron autophagy in a mouse model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Degradation of Amyotrophic Lateral Sclerosis-linked Mutant Cu,Zn-Superoxide Dismutase Proteins by Macroautophagy and the Proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Lithium delays progression of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Autophagy dysregulation in amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.25188

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.25188

Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.25188

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

mTOR signaling in growth control and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Targeting autophagy in ALS: a complex mission

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Chemical modulators of autophagy as biological probes and potential therapeutics

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.25188

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Autophagic degradation of tau in primary neurons and its enhancement by trehalose.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Mutant superoxide dismutase 1 overexpression in NSC-34 cells: effect of trehalose on aggregation, TDP-43 localization and levels of co-expressed glycoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Effect of trehalose on PC12 cells overexpressing wild-type or A53T mutant α-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Autophagy induction by trehalose counteracts cellular prion infection

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Trehalose protects from aggravation of amyloid pathology induced by isoflurane anesthesia in APP(swe) mutant mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

JNK regulates FoxO-dependent autophagy in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

FoxO transcription factors promote autophagy in cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Regulation of autophagy by ATF4 in response to severe hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Guidelines for the use and interpretation of assays for monitoring autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Autophagy and the integrated stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

A review of the neural mechanisms of action and clinical efficiency of riluzole in treating amyotrophic lateral sclerosis: what have we learned in the last decade?

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Control of autophagy as a therapy for neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

No benefit from chronic lithium dosing in a sibling-matched, gender balanced, investigator-blinded trial using a standard mouse model of familial ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Lithium lacks effect on survival in amyotrophic lateral sclerosis: a phase IIb randomised sequential trial

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Lithium carbonate in amyotrophic lateral sclerosis: lack of efficacy in a dose-finding trial

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Protein folding stress in neurodegenerative diseases: a glimpse into the ER.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Cellular toxicity of mutant SOD1 protein is linked to an easily soluble, non-aggregated form in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Guidelines for preclinical animal research in ALS/MND: A consensus meeting

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Activation of the unfolded protein response enhances motor recovery after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Axonal degeneration is mediated by the mitochondrial permeability transition pore.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

Differential roles of NMDA Receptor Subtypes NR2A and NR2B in dendritic branch development and requirement of RasGRF1.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.25188

21 January 2018

Identifiers

DOI

10.4161/AUTO.25188

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30 November 2017

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