MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis. (Q33878853)

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English	MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis.	scientific article

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5 March 2020

MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis (English)

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alpha,alpha-trehalose

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amyotrophic lateral sclerosis

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2

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author name string

Xiaojie Zhang

1

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Lin Song

3

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Yu Tang

4

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Yufei Shen

5

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Li Jia

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Weidong Le

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publication date

15 January 2014

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588-602

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4

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5 March 2020

Protein aggregation in amyotrophic lateral sclerosis.

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Mitochondrial network genes in the skeletal muscle of amyotrophic lateral sclerosis patients

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Lithium in patients with amyotrophic lateral sclerosis (LiCALS): a phase 3 multicentre, randomised, double-blind, placebo-controlled trial

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Rapamycin-induced autophagy aggravates pathology and weakness in a mouse model of VCP-associated myopathy

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Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis

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Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

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Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS

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Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications

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Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

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FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport

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Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes

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Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism.

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5 July 2018

The effects of dynein inhibition on the autophagic pathway in glioma cells

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MnSOD deficiency has a differential effect on disease progression in two different ALS mutant mouse models

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5 July 2018

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

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5 July 2018

Lithium delays progression of amyotrophic lateral sclerosis

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5 July 2018

Autophagy: process and function

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5 July 2018

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

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Interaction between familial amyotrophic lateral sclerosis (ALS)-linked SOD1 mutants and the dynein complex

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5 July 2018

Trehalose as a "chemical chaperone": fact and fantasy

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Molecular biology of amyotrophic lateral sclerosis: insights from genetics

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5 July 2018

Conditional knockout of Mn superoxide dismutase in postnatal motor neurons reveals resistance to mitochondrial generated superoxide radicals

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5 July 2018

Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy

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Gait analysis detects early changes in transgenic SOD1(G93A) mice

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Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS.

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5 July 2018

New insights on trehalose: a multifunctional molecule

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Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

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5 July 2018

Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons

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29 October 2018

Lithium lacks effect on survival in amyotrophic lateral sclerosis: a phase IIb randomised sequential trial

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Targeting autophagy in ALS: a complex mission

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29 October 2018

Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

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29 October 2018

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Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

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Autophagy in spinal cord motor neurons in sporadic amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24441414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS

1 reference

https://pubmed.ncbi.nlm.nih.gov/24441414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased autophagy in transgenic mice with a G93A mutant SOD1 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/24441414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased ER stress during motor neuron degeneration in a transgenic mouse model of amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24441414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered macroautophagy in the spinal cord of SOD1 mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24441414

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based on heuristic

inferred from PubMed ID database lookup

Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24441414

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4161/AUTO.27710

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5 March 2020

1 reference

Europe PubMed Central

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5 March 2020

1 reference

Europe PubMed Central

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5 March 2020

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