Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer (Q37032635)

17 August 2017

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title

Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer (English)

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17 August 2017

Juan M Ilarregui

4

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author name string

Mariana Salatino

1

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17 August 2017

Diego O Croci

2

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17 August 2017

Germán A Bianco

3

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17 August 2017

Marta A Toscano

5

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17 August 2017

Gabriel A Rabinovich

6

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17 August 2017

language of work or name

English

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publication date

1 January 2008

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Expert Opinion on Biological Therapy

17 August 2017

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17 August 2017

8

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17 August 2017

45-57

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17 August 2017

1

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Galectinomics: finding themes in complexity

17 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Introduction to galectins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

The coming of age of galectins as immunomodulatory agents: impact of these carbohydrate binding proteins in T cell physiology and chronic inflammatory disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Dissecting the pathophysiologic role of endogenous lectins: glycan-binding proteins with cytokine-like activity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Intracellular functions of galectins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Clusters, bundles, arrays and lattices: novel mechanisms for lectin-saccharide-mediated cellular interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectins as modulators of tumour progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Beta-galactoside-binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Nucleocytoplasmic lectins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Identification of galectin-3 as a factor in pre-mRNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Secretion of the galectin family of mammalian carbohydrate-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Cell surface counter receptors are essential components of the unconventional export machinery of galectin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Unconventional secretory routes: direct protein export across the plasma membrane of mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectin-1: a small protein with major functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Recombinant human β-galactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectin-1 suppresses experimental colitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-inflammatory responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Transgenic galectin-1 induces maturation of dendritic cells that elicit contrasting responses in naive and activated T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectin-1: a link between tumor hypoxia and tumor immune privilege

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Apoptosis of T cells mediated by galectin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Presentation of Galectin-1 by Extracellular Matrix Triggers T Cell Death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectin-1 supports survival of naive T cells without promoting cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Expression of a specific glycosyltransferase enzyme regulates T cell death mediated by galectin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectin-1 induces partial TCR zeta-chain phosphorylation and antagonizes processive TCR signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Molecular mechanisms implicated in galectin-1-induced apoptosis: activation of the AP-1 transcription factor and downregulation of Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Role of p56lck and ZAP70-mediated tyrosine phosphorylation in galectin-1-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Acid sphingomyelinase mediated release of ceramide is essential to trigger the mitochondrial pathway of apoptosis by galectin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Regulatory T cells, tumour immunity and immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectins in mouse embryogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Amelioration of graft versus host disease by galectin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Increased alpha2,6-sialylation of surface proteins on tolerogenic, immature dendritic cells and regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Tumor galectinology: insights into the complex network of a family of endogenous lectins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectins as modulators of tumor progression in head and neck squamous cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectin-1 modulates human glioblastoma cell migration into the brain through modifications to the actin cytoskeleton and levels of expression of small GTPases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectin-1 expression in cancer-associated stromal cells correlates tumor invasiveness and tumor progression in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectin-1 as a potential cancer target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Proteomic profiling identifies breast tumor metastasis-associated factors in an isogenic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Proteomic investigation of glioblastoma cell lines treated with wild-type p53 and cytotoxic chemotherapy demonstrates an association between galectin-1 and p53 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectin-1 knocking down in human U87 glioblastoma cells alters their gene expression pattern

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Immunosuppressive strategies that are mediated by tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Dynamic cross-talk between tumor and immune cells in orchestrating the immunosuppressive network at the tumor microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Regulation of galectin-1 expression by transforming growth factor beta1 in metastatic mammary adenocarcinoma cells: implications for tumor-immune escape.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Low-dose cyclophosphamide modulates galectin-1 expression and function in an experimental rat lymphoma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Differential regulation of constitutive and retinoic acid-induced galectin-1 gene transcription in murine embryonal carcinoma and myoblastic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

The AP1-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectin-1 mediated suppression of Epstein-Barr virus specific T-cell immunity in classic Hodgkin lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

O-glycosylation regulates LNCaP prostate cancer cell susceptibility to apoptosis induced by galectin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Opposite effects of galectin-1 on alternative metabolic pathways of L-arginine in resident, inflammatory, and activated macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Upregulation of galectins-1 and -3 in human colon cancer and their role in regulating cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectin 1 is involved in vascular smooth muscle cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Stimulation of proliferation of rat hepatic stellate cells by galectin-1 and galectin-3 through different intracellular signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Negative regulation of neuroblastoma cell growth by carbohydrate-dependent surface binding of galectin-1 and functional divergence from galectin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Biphasic modulation of cell growth by recombinant human galectin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

L-14 lectin recognition of laminin and its promotion of in vitro cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

A novel biological activity for galectin-1: inhibition of leukocyte-endothelial cell interactions in experimental inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Galectin-1 is overexpressed in nasal polyps under budesonide and inhibits eosinophil migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Anti-galectin compounds as potential anti-cancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Synthetic lactulose amines: novel class of anticancer agents that induce tumor-cell apoptosis and inhibit galectin-mediated homotypic cell aggregation and endothelial cell morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Autoimmune Uveitis Elicited with Antigen-Pulsed Dendritic Cells Has a Distinct Clinical Signature and Is Driven by Unique Effector Mechanisms: Initial Encounter with Autoantigen Defines Disease Phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

Strongly enhanced IL-10 production using stable galectin-1 homodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.8.1.45

21 January 2018

Identifiers

DOI

10.1517/14712598.8.1.45

1 reference

17 August 2017

1 reference