Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver (Q37066050)

18 August 2017

Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver (English)

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18 August 2017

Ningning Zhao

1

1 reference

18 August 2017

Julia E Maxson

2

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18 August 2017

Richard H Zhang

3

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18 August 2017

Mastura Wahedi

4

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18 August 2017

Caroline A Enns

5

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18 August 2017

An-Sheng Zhang

6

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18 August 2017

language of work or name

English

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publication date

12 April 2016

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18 August 2017

14

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Journal of Biological Chemistry

inferred from page(s)

published in

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18 August 2017

291

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18 August 2017

23

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18 August 2017

12322-12335

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describes a project that uses

18 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4933279/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein

29 September 2017

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A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis

29 September 2017

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Structure of the Repulsive Guidance Molecule (RGM)-Neogenin Signaling Hub

29 September 2017

1 reference

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Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933279

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

29 September 2017

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Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

29 September 2017

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Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis

29 September 2017

1 reference

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Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression

29 September 2017

1 reference

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The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo

29 September 2017

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Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis

29 September 2017

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Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis

29 September 2017

1 reference

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Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression

29 September 2017

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Lack of the bone morphogenetic protein BMP6 induces massive iron overload

29 September 2017

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Processing of hemojuvelin requires retrograde trafficking to the Golgi in HepG2 cells

29 September 2017

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The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin

29 September 2017

1 reference

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Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

29 September 2017

1 reference

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The serine protease TMPRSS6 is required to sense iron deficiency

29 September 2017

1 reference

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Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane

29 September 2017

1 reference

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Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

29 September 2017

1 reference

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Neogenin interacts with hemojuvelin through its two membrane-proximal fibronectin type III domains

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933279

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

29 September 2017

1 reference

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Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin

29 September 2017

1 reference

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Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

29 September 2017

1 reference

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Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933279

Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933279

Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin

29 September 2017

1 reference

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Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933279

Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells

29 September 2017

1 reference

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A mouse model of juvenile hemochromatosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933279

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933279

Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin

29 September 2017

1 reference

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29 September 2017

1 reference

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Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933279

Spectrum of hemojuvelin gene mutations in 1q-linked juvenile hemochromatosis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933279

Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933279

Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933279

Conditional disruption of mouse HFE2 gene: maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933279

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933279

Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin

4 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27072365

12 December 2020

inferred from PubMed ID database lookup

Defective targeting of hemojuvelin to plasma membrane is a common pathogenetic mechanism in juvenile hemochromatosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27072365

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M116.721191

1 reference

18 August 2017

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18 August 2017

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