The role of the innate immune system in Alzheimer's disease and frontotemporal lobar degeneration: an eye on microglia (Q37067641)

18 August 2017

3 references

25 April 2019

12 September 2019

12 October 2019

The role of the innate immune system in Alzheimer's disease and frontotemporal lobar degeneration: an eye on microglia (English)

1 reference

frontotemporal lobar degeneration

18 August 2017

0 references

3 references

25 April 2019

12 September 2019

12 October 2019

2 references

12 September 2019

12 October 2019

1 reference

12 September 2019

1 reference

12 October 2019

Daniela Galimberti

4

0 references

Elio Scarpini

object named as

Elio Scarpini

series ordinal

3

0 references

Cinzia Barone

series ordinal

2

object named as

Cinzia Barone

1 reference

18 August 2017

Elisa Ridolfi

1

1 reference

PMC publication ID

3732611

18 August 2017

language of work or name

1 reference

18 July 2013

4 references

Clinical and Developmental Immunology

18 August 2017

25 April 2019

12 September 2019

12 October 2019

4 references

18 August 2017

25 April 2019

12 September 2019

12 October 2019

2013

1 reference

18 August 2017

939786

1 reference

Creative Commons Attribution 3.0 Unported

18 August 2017

3 references

25 April 2019

12 September 2019

on focus list of Wikimedia project

12 October 2019

copyright status

copyrighted

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ScienceSource

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cites work

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29 September 2017

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Role of common and rare APP DNA sequence variants in Alzheimer disease

29 September 2017

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Cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia

29 September 2017

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Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia

29 September 2017

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The yin and yang of microglia

29 September 2017

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Neuropathological background of phenotypical variability in frontotemporal dementia

29 September 2017

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The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

29 September 2017

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The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

29 September 2017

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Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

29 September 2017

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Classification of primary progressive aphasia and its variants

29 September 2017

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ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels

29 September 2017

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CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice

29 September 2017

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Progranulin is a chemoattractant for microglia and stimulates their endocytic activity

29 September 2017

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Presence of reactive microglia and neuroinflammatory mediators in a case of frontotemporal dementia with P301S mutation

29 September 2017

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TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers.

29 September 2017

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Genetics of Alzheimer disease

29 September 2017

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Astrocytic gap junctional communication is reduced in amyloid-β-treated cultured astrocytes, but not in Alzheimer's disease transgenic mice

29 September 2017

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Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia

29 September 2017

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IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice

29 September 2017

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Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

29 September 2017

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Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

29 September 2017

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GRN variability contributes to sporadic frontotemporal lobar degeneration

29 September 2017

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Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

29 September 2017

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Microglia: biology and pathology

29 September 2017

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Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders

29 September 2017

1 reference

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Functional aspects of redox control during neuroinflammation

29 September 2017

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Progranulin expression is upregulated after spinal contusion in mice.

29 September 2017

1 reference

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Role of microglia in neuronal degeneration and regeneration

29 September 2017

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Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models

29 September 2017

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Melatonin as a potential therapeutic agent in psychiatric illness.

29 September 2017

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Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors

29 September 2017

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The Toll-->NFkappaB signaling pathway mediates the neuropathological effects of the human Alzheimer's Abeta42 polypeptide in Drosophila

29 September 2017

1 reference

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Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration

29 September 2017

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Novel exon 1 progranulin gene variant in Alzheimer's disease.

29 September 2017

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Intrathecal levels of IL-6, IL-11 and LIF in Alzheimer's disease and frontotemporal lobar degeneration

29 September 2017

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Glial cell dysregulation: a new perspective on Alzheimer disease

29 September 2017

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Microglia biology in health and disease.

29 September 2017

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Variable phenotype of Alzheimer's disease with spastic paraparesis

29 September 2017

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Neonatal and adult microglia cross-present exogenous antigens

29 September 2017

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Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology

29 September 2017

1 reference

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Alzheimer's disease and frontotemporal dementia: prospects of a tailored therapy?

29 September 2017

1 reference

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It may take inflammation, phosphorylation and ubiquitination to 'tangle' in Alzheimer's disease

29 September 2017

1 reference

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Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions

29 September 2017

1 reference

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Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

29 September 2017

1 reference

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Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Intrathecal chemokine synthesis in mild cognitive impairment and Alzheimer disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Comparison of family histories in FTLD subtypes and related tauopathies

29 September 2017

1 reference

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Mechanisms of cell signaling and inflammation in Alzheimer's disease

29 September 2017

1 reference

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Inflammation and the degenerative diseases of aging

29 September 2017

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Mutations causing neurodegenerative tauopathies

29 September 2017

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The role of tau (MAPT) in frontotemporal dementia and related tauopathies

29 September 2017

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TRAIL is expressed in the brain cells of Alzheimer's disease patients

29 September 2017

1 reference

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Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates

29 September 2017

2 references

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29 September 2017

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Yin and Yang: complement activation and regulation in Alzheimer’s disease

21 January 2018

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Current and Future Therapeutic Strategies to Target Inflammation in Stroke

29 September 2017

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

29 September 2017

1 reference

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Proteasome activity is critical for the cAMP-induced differentiation of neuroblastoma cells

29 September 2017

1 reference

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beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Molecular genetics of Alzheimer's disease: the role of beta-amyloid and the presenilins.

29 September 2017

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Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.

29 September 2017

1 reference

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Role of the proteasome in Alzheimer's disease

29 September 2017

1 reference

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The role of complement anaphylatoxin C5a in neurodegeneration: implications in Alzheimer's disease.

29 September 2017

1 reference

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Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta

29 September 2017

1 reference

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Proteasome inhibition in neuronal cells induces a proinflammatory response manifested by upregulation of cyclooxygenase-2, its accumulation as ubiquitin conjugates, and production of the prostaglandin PGE(2).

29 September 2017

1 reference

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Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease

29 September 2017

1 reference

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Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease

29 September 2017

1 reference

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Expression of chemokine receptors by subsets of neurons in the central nervous system

29 September 2017

1 reference

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Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro

29 September 2017

1 reference

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Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

29 September 2017

1 reference

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Induction and regulation of interleukin-6 gene expression in rat astrocytes

29 September 2017

1 reference

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Immunoreactivity of CD45, a protein phosphotyrosine phosphatase, in Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Neuropathological stageing of Alzheimer-related changes

29 September 2017

1 reference

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Complement activation by beta-amyloid in Alzheimer disease

29 September 2017

1 reference

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Exacerbated inflammatory responses related to activated microglia after traumatic brain injury in progranulin-deficient mice

29 September 2017

1 reference

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Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels

27 June 2018

1 reference

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Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Ultrastructural studies of the cells forming amyloid fibers in classical plaques.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA-1 family

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Interleukin-6 and α-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Lipopolysaccharide-induced inhibition of connexin43 gap junction communication in astrocytes is mediated by downregulation of caveolin-3.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Progranulin and beta-amyloid distribution: a case report of the brain from preclinical PS-1 mutation carrier

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Proinflammatory stimuli are needed for induction of microglial cell-mediated AbetaPP_{244-C} and Abeta-neurotoxicity in hippocampal cultures.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Smad3 null mice display more rapid wound closure and reduced scar formation after a stab wound to the cerebral cortex

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Protection of rat primary hippocampal cultures from A beta cytotoxicity by pro-inflammatory molecules is mediated by astrocytes.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

In vivo detection of microglial activation in frontotemporal dementia

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Apolipoprotein Eepsilon4 modifies Alzheimer's disease onset in an E280A PS1 kindred.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Age-dependent cytokine responses: trimethyltin hippocampal injury in wild-type, APOE knockout, and APOE4 mice

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Microglia and Alzheimer's disease

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Expression of presenilin-1 and -2 mRNAs in rat and Alzheimer's disease brains

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Alzheimer's disease and rheumatoid arthritis.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732611

Role of the proteasome in Alzheimer’s disease

4 September 2018

1 reference

https://api.crossref.org/works/10.1155%2F2013%2F939786

Phosphorylation Sites on Tau Identified by Nanoelectrospray Mass Spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2013%2F939786

Estimation of the Genetic Contribution of Presenilin-1 and -2 Mutations in a Population-Based Study of Presenile Alzheimer Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2013%2F939786

Clinical and genetic features of families with frontotemporal dementia and parkinsonism linked to chromosome 17 with a P301S tau mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2013%2F939786

Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2013%2F939786

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2013%2F939786

The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity

21 January 2018

1 reference

12 December 2020

Intrathecal synthesis of monocyte chemoattractant protein-1 (MCP-1) in amyotrophic lateral sclerosis: further evidence for microglial activation in neurodegeneration

1 reference

12 December 2020

Modulation by astrocytes of microglial cell-mediated neuroinflammation: effect on the activation of microglial signaling pathways

1 reference

12 December 2020

beta-amyloid protein enhances macrophage production of oxygen free radicals and glutamate

1 reference

12 December 2020

CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase

1 reference

12 December 2020

Prostaglandins act as neurotoxin for differentiated neuroblastoma cells in culture and increase levels of ubiquitin and beta-amyloid

1 reference

12 December 2020

Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor

1 reference

12 December 2020

Amyloid β-induced death in neurons involves glial and neuronal hemichannels

1 reference

12 December 2020

Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome

1 reference

12 December 2020

Inflammation and Alzheimer's disease

1 reference

12 December 2020

Apolipoprotein E and Alzheimer's disease. A rapidly expanding field with medical and epidemiological consequences

1 reference

12 December 2020

Identifiers

DOI

10.1155/2013/939786

1 reference

18 August 2017

1 reference

PMC publication ID

3732611

18 August 2017

PubMed publication ID

23970926

1 reference

PMC publication ID

3732611