Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates (Q28211750)

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scientific article (publication date: November 2003)

Functional γ-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and γ-secretase substrates

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English	Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates	scientific article (publication date: November 2003)	Functional γ-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and γ-secretase substrates

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20 December 2019

Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates (English)

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20 December 2019

Stéphanie Baulac

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20 December 2019

Dennis J. Selkoe

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Dennis J Selkoe

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20 December 2019

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Matthew J LaVoie

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20 December 2019

W Taylor Kimberly

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20 December 2019

Jennifer Strahle

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20 December 2019

Michael S Wolfe

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20 December 2019

Weiming Xia

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1 November 2003

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20 December 2019

Neurobiology of Disease

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20 December 2019

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20 December 2019

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20 December 2019

194-204

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20 December 2019

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Endoproteolysis of presenilin in vitro: inhibition by gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Nicastrin binds to membrane-tethered Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Wild-type and mutated nicastrins do not display aminopeptidase M- and B-like activities.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

A familial Alzheimer's disease locus on chromosome 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

A C-terminal signal prevents secretion of luminal ER proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Deciphering the genetic basis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of presenilin cofactors in the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900123-2

7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1016/S0969-9961(03)00123-2

3 references

Consolidated OpenCitations Corpus – April 2017

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22 April 2017

Europe PubMed Central

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20 December 2019

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14572442%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

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