A hitchhiker's guide to G-quadruplex ligands (Q37080928)

18 August 2017

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title

A hitchhiker's guide to G-quadruplex ligands (English)

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Marie-Paule Teulade-Fichou

18 August 2017

author

series ordinal

2

object named as

Marie-Paule Teulade-Fichou

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18 August 2017

David Monchaud

1

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publication date

14 November 2007

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Organic and Biomolecular Chemistry

18 August 2017

published in

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18 August 2017

volume

6

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18 August 2017

issue

4

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18 August 2017

page(s)

627-636

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Quadruplex DNA: sequence, topology and structure

18 August 2017

cites work

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DNA architecture: from G to Z.

21 January 2018

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Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics

21 January 2018

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G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry

21 January 2018

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DNA and its associated processes as targets for cancer therapy

21 January 2018

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Telomere maintenance as a target for anticancer drug discovery

21 January 2018

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Natural and pharmacological regulation of telomerase

21 January 2018

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Telomere inhibition and telomere disruption as processes for drug targeting

21 January 2018

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Chemical approaches to the discovery and development of cancer therapies

21 January 2018

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Physiological relevance of telomeric G-quadruplex formation: a potential drug target

21 January 2018

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Tetraplex DNA and its interacting proteins

21 January 2018

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Targeting the limitless replicative potential of cancer: the telomerase/telomere pathway

21 January 2018

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Energetics of quadruplex-drug recognition in anticancer therapy

21 January 2018

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DNA nanomachines and nanostructures involving quadruplexes.

21 January 2018

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In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei

21 January 2018

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Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function

21 January 2018

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Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA

21 January 2018

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Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo

21 January 2018

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Highly prevalent putative quadruplex sequence motifs in human DNA

21 January 2018

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Prevalence of quadruplexes in the human genome

21 January 2018

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Single-molecule conformational analysis of G-quadruplex formation in the promoter DNA duplex of the proto-oncogene c-kit.

21 January 2018

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G-quadruplexes in promoters throughout the human genome

21 January 2018

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Gene function correlates with potential for G4 DNA formation in the human genome

21 January 2018

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Retinoblastoma susceptibility genes contain 5' sequences with a high propensity to form guanine-tetrad structures

21 January 2018

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Unusual DNA structure of the diabetes susceptibility locus IDDM2 and its effect on transcription by the insulin promoter factor Pur-1/MAZ.

21 January 2018

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Formation and properties of hairpin and tetraplex structures of guanine-rich regulatory sequences of muscle-specific genes

21 January 2018

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Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents

21 January 2018

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Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1alpha promoter

21 January 2018

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The fragile X syndrome d(CGG)n nucleotide repeats form a stable tetrahelical structure

21 January 2018

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The tetraplex (CGG)n destabilizing proteins hnRNP A2 and CBF-A enhance the in vivo translation of fragile X premutation mRNA.

21 January 2018

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DNA tetraplex formation in the control region of c-myc

21 January 2018

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Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization

21 January 2018

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Induction of duplex to G-quadruplex transition in the c-myc promoter region by a small molecule

21 January 2018

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Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

21 January 2018

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G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription.

21 January 2018

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An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solution

21 January 2018

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Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter

21 January 2018

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NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region

21 January 2018

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Putative DNA quadruplex formation within the human c-kit oncogene

21 January 2018

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A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene

21 January 2018

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Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene

21 January 2018

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Spectroscopic recognition of guanine dimeric hairpin quadruplexes by a carbocyanine dye.

21 January 2018

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1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase

21 January 2018

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2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase

21 January 2018

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Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding.

21 January 2018

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Structure of a G-quadruplex-ligand complex

21 January 2018

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Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors.

21 January 2018

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Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation

21 January 2018

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Fluorescence-based melting assays for studying quadruplex ligands

21 January 2018

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Biosensor-surface plasmon resonance: quantitative analysis of small molecule-nucleic acid interactions

21 January 2018

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

21 January 2018

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Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action

21 January 2018

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The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.

21 January 2018

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A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity

21 January 2018

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Acquired cellular resistance to flavopiridol in a human colon carcinoma cell line involves up-regulation of the telomerase catalytic subunit and telomere elongation. Sensitivity of resistant cells to combination treatment with a telomerase inhibitor

21 January 2018

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Mechanism of acridine-based telomerase inhibition and telomere shortening

21 January 2018

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Biopharmaceutical characterization of the telomerase inhibitor BRACO19.

21 January 2018

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NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.

21 January 2018

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The aggregation and G-quadruplex DNA selectivity of charged 3,4,9,10-perylenetetracarboxylic acid diimides

21 January 2018

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The relationship between ligand aggregation and G-quadruplex DNA selectivity in a series of 3,4,9,10-perylenetetracarboxylic acid diimides

21 January 2018

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Evaluation of binding of perylene diimide and benzannulated perylene diimide ligands to DNA by electrospray ionization mass spectrometry.

21 January 2018

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Selective interactions of perylene derivatives having different side chains with inter- and intramolecular G-quadruplex DNA structures. A correlation with telomerase inhibition

21 January 2018

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The influence of pH on the G-quadruplex binding selectivity of perylene derivatives.

21 January 2018

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Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition

21 January 2018

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Structure of a quinobenzoxazine--G-quadruplex complex by REDOR NMR.

21 January 2018

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Structure of the first parallel DNA quadruplex-drug complex

21 January 2018

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Specific interactions of distamycin with G-quadruplex DNA.

21 January 2018

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Interactions of daidzin with intramolecular G-quadruplex.

21 January 2018

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A new steroid derivative stabilizes g-quadruplexes and induces telomere uncapping in human tumor cells.

21 January 2018

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Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay

21 January 2018

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G-quadruplex recognition by quinacridines: a SAR, NMR, and biological study

21 January 2018

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Selective recognition of G-qQuadruplex telomeric DNA by a bis(quinacridine) macrocycle

21 January 2018

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Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase

21 January 2018

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A novel inhibitor of human telomerase derived from 10H-indolo[3,2-b]quinoline

21 January 2018

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Synthesis and evaluation of analogues of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase.

21 January 2018

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Interactions of cryptolepine and neocryptolepine with unusual DNA structures.

21 January 2018

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BNIP-Salpha induces cell rounding and apoptosis by displacing p50RhoGAP and facilitating RhoA activation via its unique motifs in the BNIP-2 and Cdc42GAP homology domain.

21 January 2018

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Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives

21 January 2018

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Synthesis and testing of a triaza-cyclopenta[b]phenanthrene scaffold as a DNA binding agent

21 January 2018

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Neomycin-capped aromatic platforms: quadruplex DNA recognition and telomerase inhibition

21 January 2018

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Oxazole-based peptide macrocycles: a new class of G-quadruplex binding ligands

21 January 2018

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Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands

21 January 2018

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Furan based cyclic oligopeptides selectively target G-quadruplex

21 January 2018

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Ligand-driven G-quadruplex conformational switching by using an unusual mode of interaction

21 January 2018

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Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression

21 January 2018

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Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase

21 January 2018

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Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue

21 January 2018

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Binding of G-quadruplex-interactive agents to distinct G-quadruplexes induces different biological effects in MiaPaCa cells

21 January 2018

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Biophysical studies of the c-MYC NHE III1 promoter: model quadruplex interactions with a cationic porphyrin

21 January 2018

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Affinity and selectivity of G4 ligands measured by FRET.

21 January 2018

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A spectroscopic study on the interactions of porphyrin with G-quadruplex DNAs.

21 January 2018

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Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter

21 January 2018

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Structural basis for binding of porphyrin to human telomeres

21 January 2018

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Tetramethylpyridiniumporphyrazines--a new class of G-quadruplex inducing and stabilising ligands.

21 January 2018

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Synthesis and G-quadruplex binding studies of new 4-N-methylpyridinium porphyrins.

21 January 2018

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Cationic corrole derivatives: a new family of G-quadruplex inducing and stabilizing ligands

21 January 2018

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Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure

21 January 2018

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Telomestatin and diseleno sapphyrin bind selectively to two different forms of the human telomeric G-quadruplex structure

21 January 2018

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Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines

21 January 2018

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Antitumor polycyclic acridines. 17. Synthesis and pharmaceutical profiles of pentacyclic acridinium salts designed to destabilize telomeric integrity

21 January 2018

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Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism

21 January 2018

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Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect

21 January 2018

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Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat

21 January 2018

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Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes

21 January 2018

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Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands.

21 January 2018

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Resistance to the short term antiproliferative activity of the G-quadruplex ligand 12459 is associated with telomerase overexpression and telomere capping alteration

21 January 2018

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Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing.

21 January 2018

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Overexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescence

21 January 2018

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Stabilization of the c-myc gene promoter quadruplex by specific ligands' inhibitors of telomerase.

21 January 2018

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21 January 2018

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Preferential binding of a G-quadruplex ligand to human chromosome ends.

21 January 2018

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Quadruplex ligands may act as molecular chaperones for tetramolecular quadruplex formation

21 January 2018

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A fluorescent carbazole derivative: high sensitivity for quadruplex DNA.

21 January 2018

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Detection of quadruplex DNA structures in human telomeres by a fluorescent carbazole derivative

21 January 2018

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Investigation of spectral conversion of d(TTAGGG)4 and d(TTAGGG)13 upon potassium titration by a G-quadruplex recognizer BMVC molecule

21 January 2018

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Targeting DNA with novel diphenylcarbazoles

21 January 2018

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9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA.

21 January 2018

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Natural and synthetic G-quadruplex interactive berberine derivatives.

21 January 2018

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Molecular recognition of nucleic acids: coralyne binds strongly to poly(A).

21 January 2018

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Aggregation and G-quadruplex DNA-binding study of 6a,12a-diazadibenzo-[a,g]fluorenylium derivative.

21 January 2018

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Spectroscopic study and G-quadruplex DNA binding affinity of two bioactive papaverine-derived ligands.

21 January 2018

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G-quadruplex DNA binding by a series of carbocyanine dyes

21 January 2018

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A G-quadruplex ligand 3,3'-diethyloxadicarbocyanine iodide induces mitochondrion-mediated apoptosis but not decrease of telomerase activity in nasopharyngeal carcinoma NPC-TW01 cells

21 January 2018

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G-Quadruplex-Specific Peptide−Hemicyanine Ligands by Partial Combinatorial Selection

21 January 2018

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Hoechst 33258 binds to G-quadruplex in the promoter region of human c-myc

21 January 2018

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Parallel-stranded guanine quadruplex interactions with a copper cationic porphyrin

21 January 2018

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Porphyrin-aminoquinoline conjugates as telomerase inhibitors.

21 January 2018

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Dinuclear monointercalating RuII complexes that display high affinity binding to duplex and quadruplex DNA.

21 January 2018

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Quaternary ammonium zinc phthalocyanine: inhibiting telomerase by stabilizing G quadruplexes and inducing G-quadruplex structure transition and formation

21 January 2018

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Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex

21 January 2018

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Design and synthesis of the G-quadruplex-specific cleaving reagent perylene-EDTA.iron(II).

21 January 2018

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Electrochemical telomerase assay with ferrocenylnaphthalene diimide as a tetraplex DNA-specific binder.

21 January 2018

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Platinum cross-linking of adenines and guanines on the quadruplex structures of the AG3(T2AG3)3 and (T2AG3)4 human telomere sequences in Na+ and K+ solutions

21 January 2018

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Cross-links of quadruplex structures from human telomeric DNA by dinuclear platinum complexes show the flexibility of both structures.

21 January 2018

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A platinum-quinacridine hybrid as a G-quadruplex ligand

21 January 2018

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Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus

21 January 2018

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Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex

21 January 2018

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Telomestatin-induced stabilization of the human telomeric DNA quadruplex monitored by electrospray mass spectrometry.

21 January 2018

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Novel antitumor and neuroprotective substances discovered by characteristic screenings based on specific molecular targets

21 January 2018

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Telomerase inhibition, telomere shortening, cell growth suppression and induction of apoptosis by telomestatin in childhood neuroblastoma cells

21 January 2018

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G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells

21 January 2018

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The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells

21 January 2018

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Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells.

21 January 2018

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Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles.

21 January 2018

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Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNA

21 January 2018

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Fluorescent dyes specific for quadruplex DNA

21 January 2018

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Triplex and quadruplex DNA structures studied by electrospray mass spectrometry.

21 January 2018

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Cyclo[n]pyrroles: size and site-specific binding to G-quadruplexes

21 January 2018

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Targeting telomeres and telomerase

21 January 2018

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Highly Efficient G-Quadruplex Recognition by Bisquinolinium Compounds

21 January 2018

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The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes

21 January 2018

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Structure-specific recognition of quadruplex DNA by organic cations: Influence of shape, substituents and charge

21 January 2018

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FRET Templated by G-Quadruplex DNA: A Specific Ternary Interaction Using an Original Pair of Donor/Acceptor Partners

21 January 2018

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Stabilization and Structure of Telomeric and c-myc Region Intramolecular G-Quadruplexes: The Role of Central Cations and Small Planar Ligands

21 January 2018

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Development of a fluorescent intercalator displacement assay (G4-FID) for establishing quadruplex-DNA affinity and selectivity of putative ligands

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/B714772B

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18 August 2017

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