Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation. (Q37081904)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19068482%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation (English)

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18 January 2020

3

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18 January 2020

author name string

Chi Shing Sum

series ordinal

1

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18 January 2020

Irina G Tikhonova

series ordinal

2

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18 January 2020

Marvin C Gershengorn

series ordinal

4

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18 January 2020

language of work or name

English

0 references

publication date

8 December 2008

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18 January 2020

number of pages

8

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Journal of Biological Chemistry

inferred from page(s)

published in

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18 January 2020

volume

284

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18 January 2020

issue

6

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18 January 2020

page(s)

3529-3536

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19068482%20AND%20SRC:MED&resulttype=core&format=json

A2A adenosine receptor and its modulators: overview on a druggable GPCR and on structure-activity relationship analysis and binding requirements of agonists and antagonists

18 January 2020

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29 September 2017

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29 September 2017

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Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists

29 September 2017

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Systematic analysis of the entire second extracellular loop of the V(1a) vasopressin receptor: key residues, conserved throughout a G-protein-coupled receptor family, identified.

29 September 2017

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Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist

29 September 2017

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The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state.

29 September 2017

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Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules

29 September 2017

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Human P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference.

29 September 2017

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29 September 2017

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Agonist-induced conformational changes in thyrotropin-releasing hormone receptor type I: disulfide cross-linking and molecular modeling approaches.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch

29 September 2017

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Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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3 September 2018

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3 September 2018

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3 September 2018

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Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6.

3 September 2018

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3 September 2018

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Crossref

https://api.crossref.org/works/10.1074%2FJBC.M806987200

Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands

21 January 2018

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Role of the extracellular loops of the thyrotropin-releasing hormone receptor: evidence for an initial interaction with thyrotropin-releasing hormone

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/19068482

12 December 2020

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A chemogenomic analysis of the transmembrane binding cavity of human G-protein-coupled receptors

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PubMed

https://pubmed.ncbi.nlm.nih.gov/19068482

12 December 2020

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Multiple residues in the second extracellular loop are critical for M3 muscarinic acetylcholine receptor activation

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PubMed

https://pubmed.ncbi.nlm.nih.gov/19068482

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M806987200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19068482%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19068482%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference