Study designs for genome-wide association studies (Q37115935)

18 August 2017

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title

Study designs for genome-wide association studies (English)

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genome-wide association study

18 August 2017

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2

David G Cox

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18 August 2017

Peter Kraft

1

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18 August 2017

1 January 2008

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18 August 2017

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18 August 2017

60

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18 August 2017

465-504

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A haplotype map of the human genome

18 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Re: Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Polygenic inheritance of breast cancer: Implications for design of association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

The genetics and genomics of cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Evaluating coverage of genome-wide association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Demonstrating stratification in a European American population

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Agnosticism and equity in genome-wide association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Population genetics--making sense out of sequence

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Replicating genotype-phenotype associations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Conflicting results regarding the semaphorin gene (SEMA5A) and the risk for Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Epidemiological methods for studying genes and environmental factors in complex diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Population structure, differential bias and genomic control in a large-scale, case-control association study

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Merging and emerging cohorts: necessary but not sufficient

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

A worldwide survey of haplotype variation and linkage disequilibrium in the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Genetic association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Case/pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions, and parent-of-origin effects.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Efficiency and power in genetic association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Transferability of tag SNPs in genetic association studies in multiple populations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Genomic control for association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

A note on permutation tests in multistage association scans.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Genome-wide association study identifies novel breast cancer susceptibility loci

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

A simple and improved correction for population stratification in case-control studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Two-stage two-locus models in genome-wide association

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Genomewide association, Parkinson disease, and PARK10

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

The Correlation between Relatives on the Supposition of Mendelian Inheritance

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Genetic and Environmental Contributions to Atherosclerosis Phenotypes in Men and Women

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Assessing the impact of population stratification on genetic association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

The structure of haplotype blocks in the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

False discovery control with p-value weighting

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

In genetic control of disease, does 'race' matter?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Factors affecting statistical power in the detection of genetic association

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

No evidence for association with Parkinson disease for 13 single-nucleotide polymorphisms identified by whole-genome association screening.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

A unified approach to the analysis of case-distribution (case-only) studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

A common genetic variant is associated with adult and childhood obesity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Future directions of research in statistical genetics

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

A candidate gene approach to searching for low-penetrance breast and prostate cancer genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Scanning the horizon: what is the future of genome-wide association studies in accelerating discoveries in cancer etiology and prevention?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Finishing the euchromatic sequence of the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Why most published research findings are false

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

'Racial' differences in genetic effects for complex diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Coverage and power in genomewide association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Complement factor H polymorphism in age-related macular degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Identifying interacting SNPs using Monte Carlo logic regression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Exploiting gene-environment interaction to detect genetic associations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Prospects for whole-genome linkage disequilibrium mapping of common disease genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Initial sequencing and analysis of the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Cohort studies for characterizing measured genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

A case-control association study of the 12 single-nucleotide polymorphisms implicated in Parkinson disease by a recent genome scan

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

An efficient Monte Carlo approach to assessing statistical significance in genomic studies.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Evaluating statistical significance in two-stage genomewide association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

No gene is an island: the flip-flop phenomenon

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Comment on "A common genetic variant is associated with adult and childhood obesity"

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

High-resolution whole-genome association study of Parkinson disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

The effects of human population structure on large genetic association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Genome-wide strategies for detecting multiple loci that influence complex diseases.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

A new multipoint method for genome-wide association studies by imputation of genotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

A common allele on chromosome 9 associated with coronary heart disease

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Endogenous estrogen, androgen, and progesterone concentrations and breast cancer risk among postmenopausal women

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Undetected genotyping errors cause apparent overtransmission of common alleles in the transmission/disequilibrium test

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Considerations for genomewide association studies in Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Genome-wide tagging for everyone

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Genetic association studies of complex traits: design and analysis issues

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Generalized analysis of molecular variance

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Evidence for Heritability of Abdominal Aortic Calcific Deposits in the Framingham Heart Study

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Population structure and eigenanalysis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Evaluating and improving power in whole-genome association studies using fixed marker sets.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Polygenic susceptibility to breast cancer and implications for prevention

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Aspects of the design and analysis of high-dimensional SNP studies for disease risk estimation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Principal components analysis corrects for stratification in genome-wide association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Are rare variants responsible for susceptibility to complex diseases?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Linkage disequilibrium in humans: models and data

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Association mapping in structured populations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Detecting association in a case-control study while correcting for population stratification

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

On the allelic spectrum of human disease

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

The future of genetic studies of complex human diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases I. DNA pooling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Estimation of Regression Coefficients When Some Regressors are not Always Observed

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Using linkage genome scans to improve power of association in genome scans

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Improving power in genome-wide association studies: weights tip the scale

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Comment on "A common genetic variant is associated with adult and childhood obesity"

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Genomewide association analysis of coronary artery disease

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Optimal two-stage genotyping in population-based association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Two-Stage Designs for Gene-Disease Association Studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Two-stage designs for gene-disease association studies with sample size constraints.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Accounting for unmeasured population substructure in case-control studies of genetic association using a novel latent-class model

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

On estimating HLA/disease association with application to a study of aplastic anemia

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Cost-effective designs for linkage disequilibrium mapping of complex traits

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Logistic regression protects against population structure in genetic association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

DNA Pooling: a tool for large-scale association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Multistage sampling for disease family registries.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

A genome-wide association study identifies novel risk loci for type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Linkage disequilibrium mapping of complex disease: fantasy or reality?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

An utter refutation of the "fundamental theorem of the HapMap".

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Systematic review and meta-analysis of the association between complement factor H Y402H polymorphisms and age-related macular degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

The efficiency of matching in case-control studies of risk-factor interactions.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

The need for a systematic approach to complex pathways in molecular epidemiology

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Are we ready for genome-wide association studies?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Betting odds and genetic associations.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Commentary: the concept of 'Mendelian Randomization'.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

An utter refutation of the "Fundamental Theorem of the HapMap" by Terwilliger and Hiekkalinna.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

The problem of multiple inference in studies designed to generate hypotheses

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Recent developments in genomewide association scans: a workshop summary and review

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

A framework for controlling false discovery rates and minimizing the amount of genotyping in the search for disease mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

PBAT: a comprehensive software package for genome-wide association analysis of complex family-based studies.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Genomic screening and replication using the same data set in family-based association testing

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Confounding from cryptic relatedness in case-control association studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Selection of controls in case-control studies. II. Types of controls

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Assessing the probability that a positive report is false: an approach for molecular epidemiology studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Optimal two-stage genotyping designs for genome-wide association scans

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Genome-wide association studies: theoretical and practical concerns

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

How many diseases does it take to map a gene with SNPs?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Multiple prostate cancer risk variants on 8q24

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Asymptotic bias and efficiency in case-control studies of candidate genes and gene-environment interactions: basic family designs

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900417-8

7 January 2021

10.1016/S0065-2660(07)00417-8

Identifiers

DOI

1 reference

18 August 2017

1 reference

PubMed ID

18358330