Pharmacokinetic properties of IgG and various Fc fusion proteins in mice (Q37138252)

18 August 2017

Pharmacokinetic properties of IgG and various Fc fusion proteins in mice (English)

1 reference

18 August 2017

1 reference

7

Roland E Kontermann

1 reference

18 August 2017

Felix Unverdorben

1

1 reference

18 August 2017

Fabian Richter

2

1 reference

18 August 2017

Meike Hutt

3

1 reference

18 August 2017

Oliver Seifert

4

1 reference

18 August 2017

Pauline Malinge

5

1 reference

18 August 2017

Nicolas Fischer

6

1 reference

18 August 2017

29 October 2015

1 reference

18 August 2017

Monoclonal Antibodies

1 reference

18 August 2017

8

1 reference

18 August 2017

1

1 reference

18 August 2017

120-128

1 reference

A novel in vitro assay to predict neonatal Fc receptor-mediated human IgG half-life.

18 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Targeting FcRn for the modulation of antibody dynamics

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Fc fusion as a platform technology: potential for modulating immunogenicity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Use of Fc-Engineered Antibodies as Clearing Agents to Increase Contrast During PET.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Engineered Fc based antibody domains and fragments as novel scaffolds

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Genetically engineered humanized mouse models for preclinical antibody studies

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Engineered antibodies for molecular imaging of cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Are endosomal trafficking parameters better targets for improving mAb pharmacokinetics than FcRn binding affinity?

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Fc-fusion proteins: new developments and future perspectives.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Pharmacokinetics of engineered human monomeric and dimeric CH2 domains

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Strategies for extended serum half-life of protein therapeutics

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

The effects of affinity and valency of an albumin-binding domain (ABD) on the half-life of a single-chain diabody-ABD fusion protein

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Effects of glycosylation on the stability of protein pharmaceuticals

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Arming antibodies: prospects and challenges for immunoconjugates

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

A passionate kiss, then run: exocytosis and recycling of IgG by FcRn.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Bispecific single-chain diabody-mediated killing of endoglin-positive endothelial cells by cytotoxic T lymphocytes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Phage libraries for generation of clinically useful antibodies

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

N-glycosylation as novel strategy to improve pharmacokinetic properties of bispecific single-chain diabodies

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Analysis of a family of antibodies with different half-lives in mice fails to find a correlation between affinity for FcRn and serum half-life

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Robust recombinant FcRn production in mammalian cells enabling oriented immobilization for IgG binding studies.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Therapeutic Fc-fusion proteins and peptides as successful alternatives to antibodies

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Reduced elimination of IgG antibodies by engineering the variable region.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1: a comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human neonatal FcR.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Bi-functional cytokine fusion proteins for gene therapy and antibody-targeted treatment of cancer

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966510

Simultaneous targeting of IL2 and IL12 to Hodgkin's lymphoma cells enhances activation of resting NK cells and tumor cell lysis

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26514880

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Improved pharmacokinetics of recombinant bispecific antibody molecules by fusion to human serum albumin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26514880

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Monoclonal antibodies with identical Fc sequences can bind to FcRn differentially with pharmacokinetic consequences

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26514880

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1080/19420862.2015.1113360

1 reference

18 August 2017

1 reference

18 August 2017

PubMed publication ID

26514880

1 reference