Target validation to biomarker development: focus on RNA interference (Q37141990)

18 August 2017

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title

Target validation to biomarker development: focus on RNA interference (English)

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18 August 2017

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Riccardo Colombo

1

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18 August 2017

Jürgen Moll

series ordinal

2

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18 August 2017

publication date

1 January 2008

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Molecular Diagnosis and Therapy

18 August 2017

published in

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18 August 2017

volume

12

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18 August 2017

issue

2

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18 August 2017

page(s)

63-70

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Can the pharmaceutical industry reduce attrition rates?

18 August 2017

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Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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RNA silencing in Drosophila

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Uncovering RNAi mechanisms in plants: biochemistry enters the foray

21 January 2018

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Strategies for silencing human disease using RNA interference

21 January 2018

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Role for a bidentate ribonuclease in the initiation step of RNA interference

21 January 2018

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Approaches for chemically synthesized siRNA and vector-mediated RNAi

21 January 2018

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Phylogenetic shadowing and computational identification of human microRNA genes

21 January 2018

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Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs

21 January 2018

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Oncomirs - microRNAs with a role in cancer

21 January 2018

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MicroRNA function in animal development

21 January 2018

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Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference

21 January 2018

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Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.

21 January 2018

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Activation of the interferon system by short-interfering RNAs

21 January 2018

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21 January 2018

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RNAi-mediated gene silencing in non-human primates.

21 January 2018

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siRNAs can function as miRNAs

21 January 2018

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Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

21 January 2018

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Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

21 January 2018

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Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo.

21 January 2018

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Utilizing RNA interference to enhance cancer drug discovery

21 January 2018

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A large-scale RNAi screen in human cells identifies new components of the p53 pathway

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03256271

Genome-scale RNAi profiling of cell division in human tissue culture cells

21 January 2018

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A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

21 January 2018

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Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

21 January 2018

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High-content siRNA screening

21 January 2018

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High-throughput RNAi screening by time-lapse imaging of live human cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03256271

An approach to genomewide screens of expressed small interfering RNAs in mammalian cells.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03256271

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03256271

A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03256271

A loss-of-function RNA interference screen for molecular targets in cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03256271

Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03256271

A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3beta/FBW7 loss of function

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03256271

A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03256271

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03256271

RNA interference in cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03256271

Small interfering RNA targeting bcl-2 sensitizes malignant melanoma

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03256271

Small interfering RNA (siRNA) inhibits the expression of the Her2/neu gene, upregulates HLA class I and induces apoptosis of Her2/neu positive tumor cell lines.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03256271

Stable suppression of tumorigenicity by virus-mediated RNA interference

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03256271

Potential applications of RNA interference technology in the treatment of cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03256271

Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03256271

Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03256271

Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03256271

Biomarkers and surrogate endpoints: preferred definitions and conceptual framework

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03256271

Clinical biomarkers in drug discovery and development

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03256271

The role of mass spectrometry in biomarker discovery and measurement

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03256271

Discovery and validation of biomarkers that respond to treatment with brivanib alaninate, a small-molecule VEGFR-2/FGFR-1 antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03256271

Context matters: the hen or egg problem in Ewing's sarcoma.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03256271

Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03256271

Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells

21 January 2018

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Ribozyme technology for cancer gene target identification and validation

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12 December 2020

Oncogenic BRAF is required for tumor growth and maintenance in melanoma models

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12 December 2020

Identification and validation of genes involved in the pathogenesis of colorectal cancer using cDNA microarrays and RNA interference.

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12 December 2020

Neoplastic transformation of normal hematopoietic cells by constitutively activating mutations of c-kit receptor tyrosine kinase

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12 December 2020

Nucleic acid aptamers for target validation and therapeutic applications

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12 December 2020

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12 December 2020

Identifiers

DOI

10.1007/BF03256271

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18 August 2017

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