Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation. (Q37160968)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19224863%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation (English)

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21 January 2020

1 reference

7

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21 January 2020

Simone Engelender

8

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21 January 2020

author name string

Raymonde Szargel

1

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21 January 2020

Ruth Rott

2

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21 January 2020

Allon Eyal

3

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21 January 2020

Joseph Haskin

4

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21 January 2020

Vered Shani

5

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21 January 2020

Livia Balan

6

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21 January 2020

language of work or name

English

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publication date

17 February 2009

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Journal of Biological Chemistry

21 January 2020

published in

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21 January 2020

volume

284

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21 January 2020

issue

17

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21 January 2020

page(s)

11706-11716

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Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes

21 January 2020

cites work

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Synphilin-1 isoforms in Parkinson's disease: regulation by phosphorylation and ubiquitylation

6 September 2017

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Siah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosis

6 September 2017

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S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding

6 September 2017

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Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia

6 September 2017

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Seven in absentia homolog 1A mediates ubiquitination and degradation of group 1 metabotropic glutamate receptors

6 September 2017

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Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease

6 September 2017

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Siah-1 facilitates ubiquitination and degradation of synphilin-1

6 September 2017

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The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

6 September 2017

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Dorfin Localizes to Lewy Bodies and Ubiquitylates Synphilin-1

6 September 2017

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Inhibition of ubiquitin ligase Siah-1A by disabled-1

6 September 2017

1 reference

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A binding motif for Siah ubiquitin ligase.

6 September 2017

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Parkin accumulation in aggresomes due to proteasome impairment

6 September 2017

1 reference

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Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein

6 September 2017

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Regulation of synaptophysin degradation by mammalian homologues of seven in absentia

6 September 2017

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Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling

6 September 2017

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Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

6 September 2017

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Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli

6 September 2017

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SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1)

6 September 2017

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Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

6 September 2017

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alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

6 September 2017

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

6 September 2017

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Characterization of human homologs of the Drosophila seven in absentia (sina) gene

6 September 2017

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Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway

6 September 2017

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6 September 2017

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Differential effects of overexpression of wild-type and mutant human alpha-synuclein on MPP+-induced neurotoxicity in PC12 cells

6 September 2017

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Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells

14 September 2017

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Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation.

14 September 2017

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alpha-Synuclein protects SH-SY5Y cells from dopamine toxicity

14 September 2017

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Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress

14 September 2017

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Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation.

14 September 2017

1 reference

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Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.

14 September 2017

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Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition

14 September 2017

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UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease

14 September 2017

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The ubiquitin pathway in Parkinson's disease

14 September 2017

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Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death.

27 June 2018

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Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.

3 September 2018

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Synphilin in normal human brains and in synucleinopathies: studies with new antibodies

3 September 2018

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Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

3 September 2018

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Immunocytochemical localization of synphilin-1, an alpha-synuclein-associated protein, in neurodegenerative disorders

3 September 2018

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Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

3 September 2018

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Proteasomal function is impaired in substantia nigra in Parkinson's disease

3 September 2018

1 reference

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Synphilin-1 is present in Lewy bodies in Parkinson's disease

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19224863

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M805990200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19224863%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19224863%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

PubMed publication ID

19224863

1 reference