Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal Processes (Q37162698)

18 August 2017

Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal Processes (English)

1 reference

18 August 2017

1

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12 June 2020

Yan Hong

series ordinal

2

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12 June 2020

Shihua Li

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4

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12 June 2020

author name string

Shihua Li

series ordinal

3

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12 June 2020

language of work or name

English

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publication date

1 August 2016

1 reference

18 August 2017

Journal of Neuroscience

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12 June 2020

volume

36

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12 June 2020

issue

32

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12 June 2020

page(s)

8317-8328

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Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes

12 June 2020

cites work

1 reference

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6 September 2017

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Proteasome activation: An innovative promising approach for delaying aging and retarding age-related diseases.

6 September 2017

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Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes

6 September 2017

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The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation

6 September 2017

1 reference

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Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms

6 September 2017

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Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration.

6 September 2017

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Axonal transport deficits and neurodegenerative diseases

6 September 2017

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Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease

6 September 2017

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Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62.

6 September 2017

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Huntington's disease: from molecular pathogenesis to clinical treatment

6 September 2017

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Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease

6 September 2017

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Molecular mechanisms and potential therapeutical targets in Huntington's disease

6 September 2017

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Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments

6 September 2017

1 reference

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Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

6 September 2017

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The ubiquitin-proteasome reporter GFPu does not accumulate in neurons of the R6/2 transgenic mouse model of Huntington's disease

6 September 2017

1 reference

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Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons

6 September 2017

1 reference

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Huntington's disease: degradation of mutant huntingtin by autophagy

6 September 2017

1 reference

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Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin

6 September 2017

1 reference

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Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice

6 September 2017

1 reference

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Axonal degeneration in motor neuron disease

6 September 2017

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Ubiquitin: structures, functions, mechanisms

6 September 2017

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Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro

6 September 2017

1 reference

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Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

6 September 2017

1 reference

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Protein degradation and protection against misfolded or damaged proteins

6 September 2017

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The hunt for huntingtin function: interaction partners tell many different stories

6 September 2017

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Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington's disease

6 September 2017

1 reference

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Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

6 September 2017

1 reference

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Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

6 September 2017

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Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

6 September 2017

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

6 September 2017

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

6 September 2017

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Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion

6 September 2017

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Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

14 September 2017

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Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

27 June 2018

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Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice.

3 September 2018

1 reference

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3 September 2018

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10.1523/JNEUROSCI.0806-16.2016

3 September 2018

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