Axonal transport deficits and neurodegenerative diseases (Q38077679)

28 August 2017

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title

Axonal transport deficits and neurodegenerative diseases (English)

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28 August 2017

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2

Jean-Pierre Julien

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28 August 2017

Stéphanie Millecamps

1

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PubMed ID

23361386

28 August 2017

language of work or name

English

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publication date

30 January 2013

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Nature Reviews Neuroscience

28 August 2017

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28 August 2017

14

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28 August 2017

161-176

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28 August 2017

3

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https://scigraph.springernature.com/pub.10.1038/nrn3380

28 August 2017

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cites work

Retrograde axonal transport: pathways to cell death?

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Neurofilaments are transported rapidly but intermittently in axons: implications for slow axonal transport.

31 March 2020

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Rapid movement of axonal neurofilaments interrupted by prolonged pauses

31 March 2020

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Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

31 March 2020

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Conditional NF-L transgene expression in mice for in vivo analysis of turnover and transport rate of neurofilaments.

31 March 2020

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Real-time imaging reveals defects of fast axonal transport induced by disorganization of intermediate filaments.

31 March 2020

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Axonal transport of the cytoplasmic matrix.

31 March 2020

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Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A.

31 March 2020

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Tight functional coupling of kinesin-1A and dynein motors in the bidirectional transport of neurofilaments

31 March 2020

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Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.

31 March 2020

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Intracellular transport and kinesin superfamily proteins, KIFs: structure, function, and dynamics

31 March 2020

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Microtubule acetylation promotes kinesin-1 binding and transport.

31 March 2020

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Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules

31 March 2020

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Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites

31 March 2020

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Cytoplasmic dynein in neurodegeneration

31 March 2020

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31 March 2020

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Walking to work: roles for class V myosins as cargo transporters

31 March 2020

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Direct interaction of microtubule- and actin-based transport motors

31 March 2020

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Myosin-Va binds to and mechanochemically couples microtubules to actin filaments

31 March 2020

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Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density

31 March 2020

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The myosin Va head domain binds to the neurofilament-L rod and modulates endoplasmic reticulum (ER) content and distribution within axons

31 March 2020

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Myosin Va and microtubule-based motors are required for fast axonal retrograde transport of tetanus toxin in motor neurons

31 March 2020

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Myosin Va maneuvers through actin intersections and diffuses along microtubules

31 March 2020

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Phosphorylation of kinesin in vivo correlates with organelle association and neurite outgrowth

31 March 2020

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Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility

31 March 2020

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Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue

31 March 2020

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Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.

31 March 2020

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A role for cyclin-dependent kinase(s) in the modulation of fast anterograde axonal transport: effects defined by olomoucine and the APC tumor suppressor protein

31 March 2020

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A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons

31 March 2020

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Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments.

31 March 2020

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Cdk5 regulates axonal transport and phosphorylation of neurofilaments in cultured neurons

31 March 2020

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The high and middle molecular weight neurofilament subunits regulate the association of neurofilaments with kinesin: inhibition by phosphorylation of the high molecular weight subunit

31 March 2020

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Differential regulation of dynein and kinesin motor proteins by tau

31 March 2020

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Multiple-motor based transport and its regulation by Tau.

31 March 2020

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The nucleotide-binding state of microtubules modulates kinesin processivity and the ability of Tau to inhibit kinesin-mediated transport

31 March 2020

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Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice

31 March 2020

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Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles

31 March 2020

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A hundred years of Alzheimer's disease research

31 March 2020

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Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

31 March 2020

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Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

31 March 2020

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Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport

31 March 2020

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Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1

31 March 2020

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Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

31 March 2020

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Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy.

31 March 2020

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Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

31 March 2020

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Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited

31 March 2020

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Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides.

31 March 2020

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Glutamate and Amyloid β-Protein Rapidly Inhibit Fast Axonal Transport in Cultured Rat Hippocampal Neurons by Different Mechanisms

31 March 2020

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Acute impairment of mitochondrial trafficking by beta-amyloid peptides in hippocampal neurons.

31 March 2020

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Amyloid-beta peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3beta in primary cultured hippocampal neurons.

31 March 2020

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Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

31 March 2020

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Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

31 March 2020

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Single-molecule investigation of the interference between kinesin, tau and MAP2c

31 March 2020

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Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease

31 March 2020

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Tau binding to microtubules does not directly affect microtubule-based vesicle motility.

31 March 2020

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The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity.

31 March 2020

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Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases

31 March 2020

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Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes

31 March 2020

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

31 March 2020

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Reduction of acetylated alpha-tubulin immunoreactivity in neurofibrillary tangle-bearing neurons in Alzheimer's disease.

31 March 2020

2 references

31 March 2020

12 December 2020

Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice.

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p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.

31 March 2020

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Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport

31 March 2020

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Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

31 March 2020

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Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.

31 March 2020

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Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro

31 March 2020

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Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons

31 March 2020

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Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin

31 March 2020

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Huntingtin facilitates dynein/dynactin-mediated vesicle transport.

31 March 2020

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Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes

31 March 2020

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Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

31 March 2020

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Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.

31 March 2020

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Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

31 March 2020

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Lysine acetylation targets protein complexes and co-regulates major cellular functions

31 March 2020

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Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

31 March 2020

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Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease

31 March 2020

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HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

31 March 2020

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Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin

31 March 2020

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Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motor neuronal processes

31 March 2020

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JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport

31 March 2020

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Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy.

31 March 2020

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Reversible disruption of dynactin 1-mediated retrograde axonal transport in polyglutamine-induced motor neuron degeneration.

31 March 2020

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Absence of disturbed axonal transport in spinal and bulbar muscular atrophy

31 March 2020

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Recent advances in the genetics of spastic paraplegias

31 March 2020

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Genetics of motor neuron disorders: new insights into pathogenic mechanisms

31 March 2020

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High frequency of partial SPAST deletions in autosomal dominant hereditary spastic paraplegia

31 March 2020

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A mutation of spastin is responsible for swellings and impairment of transport in a region of axon characterized by changes in microtubule composition.

31 March 2020

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Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

31 March 2020

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Human spastin has multiple microtubule-related functions

31 March 2020

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Hereditary spastic paraparesis: disrupted intracellular transport associated with spastin mutation

31 March 2020

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Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia

31 March 2020

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The hereditary spastic paraplegia protein spastin interacts with the ESCRT-III complex-associated endosomal protein CHMP1B.

31 March 2020

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Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower motor neuron degeneration.

31 March 2020

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Long-term course and mutational spectrum of spatacsin-linked spastic paraplegia

31 March 2020

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Effect of spastic paraplegia mutations in KIF5A kinesin on transport activity

31 March 2020

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Complicated forms of autosomal dominant hereditary spastic paraplegia are frequent in SPG10.

31 March 2020

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Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport

31 March 2020

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Mechanisms of disease: a molecular genetic update on hereditary axonal neuropathies

31 March 2020

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Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A

31 March 2020

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Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot-Marie-Tooth type 2A.

31 March 2020

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Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A.

31 March 2020

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Altered axonal mitochondrial transport in the pathogenesis of Charcot-Marie-Tooth disease from mitofusin 2 mutations

31 March 2020

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Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex

31 March 2020

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Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

31 March 2020

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Bioenergetic defect associated with mKATP channel opening in a mouse model carrying a mitofusin 2 mutation

31 March 2020

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Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway

31 March 2020

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Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport.

31 March 2020

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Mutations in the neurofilament light gene linked to Charcot-Marie-Tooth disease cause defects in transport

31 March 2020

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A mutation in the small heat-shock protein HSPB1 leading to distal hereditary motor neuronopathy disrupts neurofilament assembly and the axonal transport of specific cellular cargoes.

31 March 2020

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Disruption of neurofilament network with aggregation of light neurofilament protein: a common pathway leading to motor neuron degeneration due to Charcot-Marie-Tooth disease-linked mutations in NFL and HSPB1.

31 March 2020

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HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

31 March 2020

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Exome sequencing identifies a DYNC1H1 mutation in a large pedigree with dominant axonal Charcot-Marie-Tooth disease

31 March 2020

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Mutations in dynein link motor neuron degeneration to defects in retrograde transport

31 March 2020

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Deficits in axonal transport precede ALS symptoms in vivo

31 March 2020

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Proprioceptive sensory neuropathy in mice with a mutation in the cytoplasmic Dynein heavy chain 1 gene

31 March 2020

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Ultrastructure of swollen proximal axons of anterior horn neurons in motor neuron disease

31 March 2020

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Peripherin and neurofilament protein coexist in spinal spheroids of motor neuron disease

31 March 2020

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Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

31 March 2020

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Glutamate slows axonal transport of neurofilaments in transfected neurons

31 March 2020

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Tumor necrosis factor induces hyperphosphorylation of kinesin light chain and inhibits kinesin-mediated transport of mitochondria

31 March 2020

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Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis

31 March 2020

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Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis

31 March 2020

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Novel insertion in the KSP region of the neurofilament heavy gene in amyotrophic lateral sclerosis (ALS)

31 March 2020

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A frameshift deletion in peripherin gene associated with amyotrophic lateral sclerosis

31 March 2020

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Functions of intermediate filaments in neuronal development and disease

31 March 2020

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Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis

31 March 2020

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Defective axonal transport of neurofilament proteins in neurons overexpressing peripherin

31 March 2020

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Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments.

31 March 2020

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Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).

31 March 2020

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Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

31 March 2020

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ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

31 March 2020

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An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

31 March 2020

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Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons

31 March 2020

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Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation

31 March 2020

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Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression.

31 March 2020

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Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions

31 March 2020

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Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.

31 March 2020

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Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content

31 March 2020

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Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset.

31 March 2020

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Increased axonal mitochondrial mobility does not slow amyotrophic lateral sclerosis (ALS)-like disease in mutant SOD1 mice

31 March 2020

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Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis.

31 March 2020

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A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice

31 March 2020

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Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration.

31 March 2020

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Mutant dynactin in motor neuron disease.

31 March 2020

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The G59S mutation in p150(glued) causes dysfunction of dynactin in mice

31 March 2020

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Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking

31 March 2020

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Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactin

31 March 2020

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A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice

31 March 2020

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ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics

31 March 2020

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Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities

31 March 2020

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Als2 mRNA splicing variants detected in KO mice rescue severe motor dysfunction phenotype in Als2 knock-down zebrafish.

31 March 2020

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Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates.

31 March 2020

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Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction

31 March 2020

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Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons

31 March 2020

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Expanding insights of mitochondrial dysfunction in Parkinson's disease.

31 March 2020

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1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C

31 March 2020

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Integrating multiple aspects of mitochondrial dynamics in neurons: age-related differences and dynamic changes in a chronic rotenone model

31 March 2020

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DCTN1 mutations in Perry syndrome

31 March 2020

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Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease

31 March 2020

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[35S]Methionine metabolic labeling to study axonal transport of neuronal intermediate filament proteins in vivo.

31 March 2020

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Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function

31 March 2020

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Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy

31 March 2020

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A hexanucleotide repeat expansion in C9ORF72 links amyotrophic lateral sclerosis and frontotemporal dementia

31 March 2020

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Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB-mediated pathogenic pathways

31 March 2020

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Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies

31 March 2020

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RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments

31 March 2020

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A role for huntington disease protein in dendritic RNA granules

31 March 2020

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Fast axonal transport in squid giant axon

31 March 2020

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Fast axonal transport in extruded axoplasm from squid giant axon

31 March 2020

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Imaging axonal transport of mitochondria in vivo

31 March 2020

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A microfluidic culture platform for CNS axonal injury, regeneration and transport

31 March 2020

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Quantitative in vivo measurement of early axonal transport deficits in a triple transgenic mouse model of Alzheimer's disease using manganese-enhanced MRI

31 March 2020

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Retrograde axonal transport of herpes simplex virus: evidence for a single mechanism and a role for tegument

31 March 2020

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Impairment of retrograde axonal transport in wobbler mouse motor neuron disease

31 March 2020

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Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C.

31 March 2020

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12 December 2020

The likelihood of being affected with Huntington disease by a particular age, for a specific CAG size

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12 December 2020

Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport

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12 December 2020

Phosphorylation of neurofilament heavy chain side-arms by stress activated protein kinase-1b/Jun N-terminal kinase-3

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12 December 2020

Transport of Neuronal BC1 RNA in Mauthner Axons

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12 December 2020

Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisation

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12 December 2020

Identifiers

DOI

10.1038/NRN3380

1 reference

PubMed ID

23361386

Dimensions Publication ID

28 August 2017

0 references

1 reference

PubMed ID

23361386