The pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance (Q37164434)

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scientific article published on May 2008

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English	The pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance	scientific article published on May 2008

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scholarly article

1 reference

Europe PubMed Central

18 August 2017

The pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance (English)

1 reference

Europe PubMed Central

18 August 2017

Andrea B. Troxel

object named as

Andrea B Troxel

7

0 references

Trevor M Penning

object named as

Trevor M Penning

9

0 references

author name string

Jong-Heum Park

1

1 reference

Europe PubMed Central

18 August 2017

Stacy Gelhaus

2

1 reference

Europe PubMed Central

18 August 2017

Srilakshmi Vedantam

3

1 reference

Europe PubMed Central

18 August 2017

Andrea L Oliva

4

1 reference

Europe PubMed Central

18 August 2017

Abhita Batra

5

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Europe PubMed Central

18 August 2017

Ian A Blair

6

1 reference

Europe PubMed Central

18 August 2017

Jeffrey Field

8

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Europe PubMed Central

18 August 2017

publication date

1 May 2008

1 reference

Europe PubMed Central

18 August 2017

Chemical Research in Toxicology

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Europe PubMed Central

18 August 2017

21

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Europe PubMed Central

18 August 2017

5

1 reference

Europe PubMed Central

18 August 2017

1039-1049

1 reference

Europe PubMed Central

18 August 2017

Comparison of p53 mutations induced by PAH o-quinones with those caused by anti-benzo[a]pyrene diol epoxide in vitro: role of reactive oxygen and biological selection

1 reference

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Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair

1 reference

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Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products

1 reference

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Poleta, Polzeta and Rev1 together are required for G to T transversion mutations induced by the (+)- and (-)-trans-anti-BPDE-N2-dG DNA adducts in yeast cells

1 reference

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Generation of mutator mutants during carcinogenesis

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Origins and selection of p53 mutations in lung carcinogenesis

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The TP53 gene, tobacco exposure, and lung cancer

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Human lung cancer and p53: the interplay between mutagenesis and selection

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Transcription coupled repair of 8-oxoguanine in murine cells: the ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences

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Dominant-negative mutations of the tumor suppressor p53 relating to early onset of glioblastoma multiforme

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A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer

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Cytosine methylation determines hot spots of DNA damage in the human P53 gene

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Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.

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Dominant-negative p53 mutations selected in yeast hit cancer hot spots

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Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

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p53 mutations in human cancers

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Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers

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Quantification of benzo[a]pyrene diol epoxide DNA-adducts by stable isotope dilution liquid chromatography/tandem mass spectrometry

1 reference

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Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study

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Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes

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Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by the aldo-keto-reductases (AKRs) generate abasic sites, oxidized pyrimidines, and 8-oxo-dGuo via reactive oxygen species

1 reference

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Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo) by PAH o-quinones: involvement of reactive oxygen species and copper(II)/copper(I) redox cycling

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Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.

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p53: a two-faced cancer gene.

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p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

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On the origin of p53 G:C --> T:A transversions in lung cancers

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Reactive oxygen species generated by PAH o-quinones cause change-in-function mutations in p53.

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The IARC TP53 database: new online mutation analysis and recommendations to users

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Tumour p53 mutations exhibit promoter selective dominance over wild type p53.

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Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo[a]pyrene diol epoxide in mammalian cells: similarities with the p53 mutation spectrum in smoking-associated lung cancers.

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The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation

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Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: generation of reactive and redox active o-quinones.

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Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione

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Identifiers

10.1021/TX700404A

1 reference

Europe PubMed Central

18 August 2017

1 reference

Europe PubMed Central

18 August 2017

1 reference

Europe PubMed Central

18 August 2017

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