Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2. (Q37168382)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19211671%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2 (English)

1 reference

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21 January 2020

main subject

diethylhexyl phthalate

1 reference

ChEBI release 2020-05-28

5

1 reference

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21 January 2020

author name string

Joshua G DeKeyser

1

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21 January 2020

Michael C Stagliano

2

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21 January 2020

Scott S Auerbach

3

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21 January 2020

K Sandeep Prabhu

4

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21 January 2020

Curtis J Omiecinski

6

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21 January 2020

publication date

11 February 2009

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21 January 2020

published in

Molecular Pharmacology

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21 January 2020

volume

75

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21 January 2020

issue

5

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21 January 2020

page(s)

1005-1013

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19211671%20AND%20SRC:MED&resulttype=core&format=json

The roles of nuclear receptors CAR and PXR in hepatic energy metabolism

21 January 2020

cites work

1 reference

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Di(2-ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men.

6 September 2017

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6 September 2017

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CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics

6 September 2017

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NTP-CERHR Expert Panel Update on the Reproductive and Developmental Toxicity of di(2-ethylhexyl) phthalate

6 September 2017

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Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers

6 September 2017

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Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver.

6 September 2017

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6 September 2017

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Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3).

6 September 2017

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Phthalate exposure and early thelarche

6 September 2017

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Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptor

6 September 2017

1 reference

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In utero exposure to di-(2-ethylhexyl)phthalate and duration of human pregnancy

6 September 2017

1 reference

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Alternatively spliced isoforms of the human constitutive androstane receptor

6 September 2017

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Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

6 September 2017

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Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

6 September 2017

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Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR

6 September 2017

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6 September 2017

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Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

6 September 2017

1 reference

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Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta

6 September 2017

1 reference

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Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

6 September 2017

1 reference

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Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

6 September 2017

1 reference

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A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

6 September 2017

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The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

6 September 2017

1 reference

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Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles

28 September 2017

1 reference

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Phthalate ester effects on rat Sertoli cell function in vitro: effects of phthalate side chain and age of animal

28 September 2017

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Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice.

27 June 2018

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Species differences in the metabolism of di(2-ethylhexyl) phthalate (DEHP) in several organs of mice, rats, and marmosets

3 September 2018

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A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer

3 September 2018

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Phthalate exposure and reproductive hormones in adult men.

3 September 2018

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Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences

3 September 2018

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The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction

3 September 2018

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Identification of novel alternative splice variants of human constitutive androstane receptor and characterization of their expression in the liver

3 September 2018

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3 September 2018

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Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity

3 September 2018

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Male reproductive effects of phthalates: an emerging picture

3 September 2018

1 reference

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Multiple forms of human P450 expressed in Saccharomyces cerevisiae. Systematic characterization and comparison with those of the rat

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19211671

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/MOL.108.053702

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19211671%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19211671%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

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