Regulation of TNFR1 and CD95 signalling by receptor compartmentalization (Q37188507)

18 August 2017

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title

Regulation of TNFR1 and CD95 signalling by receptor compartmentalization (English)

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18 August 2017

Stefan Schütze

1

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18 August 2017

Vladimir Tchikov

series ordinal

2

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18 August 2017

Wulf Schneider-Brachert

series ordinal

3

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18 August 2017

11 June 2008

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Nature Reviews Molecular Cell Biology

18 August 2017

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18 August 2017

9

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18 August 2017

8

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18 August 2017

655-662

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https://scigraph.springernature.com/pub.10.1038/nrm2430

18 August 2017

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FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.

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FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

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Role of acidic sphingomyelinase in Fas/CD95-mediated cell death.

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Sphingolipids and cell death.

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Acid sphingomyelinase-derived ceramide is not required for inflammatory cytokine signalling in murine macrophages

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A novel cytoplasmic domain of the p55 tumor necrosis factor receptor initiates the neutral sphingomyelinase pathway

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FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase

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Activation of p42/p44 mitogen-activated protein kinases (MAPK) and p38 MAPK by tumor necrosis factor (TNF) is mediated through the death domain of the 55-kDa TNF receptor

31 March 2020

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TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase

31 March 2020

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Requirement of FADD for tumor necrosis factor-induced activation of acid sphingomyelinase

31 March 2020

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Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis

31 March 2020

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Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation

31 March 2020

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Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

31 March 2020

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Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis

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Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells

31 March 2020

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Fas/CD95/Apo-I activates the acidic sphingomyelinase via caspases.

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TRAIL activates acid sphingomyelinase via a redox mechanism and releases ceramide to trigger apoptosis

31 March 2020

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The murine TRAIL receptor signals caspase-independent cell death through ceramide

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The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

31 March 2020

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The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation

31 March 2020

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CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation

31 March 2020

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Function and regulation of the CD95 (APO-1/Fas) ligand in the immune system

31 March 2020

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The CD95 Receptor: Apoptosis Revisited

31 March 2020

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Molecular ordering of the initial signaling events of CD95.

31 March 2020

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Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling

31 March 2020

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SPOTS: signaling protein oligomeric transduction structures are early mediators of death receptor-induced apoptosis at the plasma membrane

31 March 2020

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The role of receptor internalization in CD95 signaling

31 March 2020

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CD95 death-inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells.

31 March 2020

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Palmitoylation is required for efficient Fas cell death signaling

31 March 2020

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CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway

31 March 2020

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Regulating Vav1 phosphorylation by the SHP-1 tyrosine phosphatase is a fine-tuning mechanism for the negative regulation of DISC formation and Fas-mediated cell death signaling

31 March 2020

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CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells

31 March 2020

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Non-apoptotic signaling pathways activated by soluble Fas ligand in serum-starved human fibroblasts. Mitogen-activated protein kinases and NF-kappaB-dependent gene expression.

31 March 2020

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The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

31 March 2020

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The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation.

31 March 2020

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Palmitoylation of intracellular signaling proteins: regulation and function

31 March 2020

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Death-receptor activation halts clathrin-dependent endocytosis

31 March 2020

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Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM2430

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Dimensions Publication ID

18 August 2017

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