Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t. (Q37208910)

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28 January 2020

title

Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t (English)

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28 January 2020

1

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7

Danila Valmori

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28 January 2020

author name string

Florence Deknuydt

2

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28 January 2020

Isabelle Raimbaud

3

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Christelle Dousset

4

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Lucie Leveque

5

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28 January 2020

Gilles Bioley

6

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28 January 2020

language of work or name

English

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publication date

13 May 2009

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Proceedings of the National Academy of Sciences of the United States of America

28 January 2020

published in

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28 January 2020

volume

106

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issue

21

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28 January 2020

page(s)

8635-8640

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DC activated via dectin-1 convert Treg into IL-17 producers

28 January 2020

cites work

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6 September 2017

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In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells

6 September 2017

1 reference

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The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat

6 September 2017

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gammadelta T cells: an important source of IL-17.

6 September 2017

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TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

6 September 2017

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Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes.

6 September 2017

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Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells

6 September 2017

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Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype

6 September 2017

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Phenotypic and functional features of human Th17 cells

6 September 2017

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IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

6 September 2017

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Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells

6 September 2017

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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

6 September 2017

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CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

6 September 2017

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Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

6 September 2017

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

6 September 2017

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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

6 September 2017

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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

6 September 2017

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A peripheral circulating compartment of natural naive CD4 Tregs

6 September 2017

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Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells

6 September 2017

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

6 September 2017

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Control of regulatory T cell development by the transcription factor Foxp3

6 September 2017

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The lineage decisions of helper T cells

6 September 2017

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Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

6 September 2017

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Role of the nuclear hormone receptor ROR gamma in transcriptional regulation, thymocyte survival, and lymphoid organogenesis

6 September 2017

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RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells

6 September 2017

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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

6 September 2017

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6 September 2017

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Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat

6 September 2017

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Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor.

14 September 2017

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Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells

26 June 2018

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Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

3 September 2018

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IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection.

3 September 2018

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Cutting edge: C3, a key component of complement activation, is not required for the development of myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis in mice

3 September 2018

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12 December 2020

IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination

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12 December 2020

Foxp3-dependent programme of regulatory T-cell differentiation

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12 December 2020

Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta

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12 December 2020

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0900621106

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28 January 2020

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