Targeting Homer genes using adeno-associated viral vector: lessons learned from behavioural and neurochemical studies. (Q37238775)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18690104%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

review article

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title

Targeting Homer genes using adeno-associated viral vector: lessons learned from behavioural and neurochemical studies (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18690104%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

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Matthias Klugmann

1

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11 January 2020

Karen K Szumlinski

series ordinal

2

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11 January 2020

publication date

1 September 2008

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11 January 2020

published in

Behavioural Pharmacology

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11 January 2020

volume

19

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11 January 2020

issue

5-6

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11 January 2020

page(s)

485-500

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Co-expression of metabotropic glutamate receptor type 1alpha with homer-1a/Vesl-1S increases the cell surface expression of the receptor

11 January 2020

cites work

1 reference

12 December 2020

Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin

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12 December 2020

Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins

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12 December 2020

Homer 1b regulates the trafficking of group I metabotropic glutamate receptors

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12 December 2020

Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is expressed in developing mouse cerebellar granule cells

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Enhanced expression of transgenes from adeno-associated virus vectors with the woodchuck hepatitis virus posttranscriptional regulatory element: implications for gene therapy

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Functional genomics and rat models

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Involvement of unique leucine-zipper motif of PSD-Zip45 (Homer 1c/vesl-1L) in group 1 metabotropic glutamate receptor clustering

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12 December 2020

Up-regulation of cortical AMPA receptor binding in the fawn-hooded rat following ethanol withdrawal

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12 December 2020

Mouse brain and muscle tissues constitutively express high levels of Homer proteins

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12 December 2020

Homer-1c/Vesl-1L modulates the cell surface targeting of metabotropic glutamate receptor type 1alpha: evidence for an anchoring function

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12 December 2020

Taurine blocks the glutamate increase in the nucleus accumbens microdialysate of ethanol-dependent rats

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12 December 2020

Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition

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12 December 2020

Prenatal and postnatal exposure to ethanol induces changes in the shape of the dendritic spines from hippocampal CA1 pyramidal neurons of the rat

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12 December 2020

Influence of promoter and WHV post-transcriptional regulatory element on AAV-mediated transgene expression in the rat brain

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12 December 2020

Homer proteins regulate coupling of group I metabotropic glutamate receptors to N-type calcium and M-type potassium channels

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12 December 2020

In vivo transduction of cerebellar Purkinje cells using adeno-associated virus vectors

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12 December 2020

Dendritic and axonal targeting of type 5 metabotropic glutamate receptor is regulated by homer1 proteins and neuronal excitation

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12 December 2020

Gene therapy: trials and tribulations

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12 December 2020

Ethanol and NMDA receptor signaling

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12 December 2020

Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer

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12 December 2020

Regulation of dendritic spine morphology and synaptic function by Shank and Homer

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12 December 2020

Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes.

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12 December 2020

Characterization of a metabotropic glutamate receptor type 5-green fluorescent protein chimera (mGluR5-GFP): pharmacology, surface expression, and differential effects of Homer-1a and Homer-1c

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12 December 2020

Repeated cocaine administration attenuates group I metabotropic glutamate receptor-mediated glutamate release and behavioral activation: a potential role for Homer.

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12 December 2020

Viral-based gene transfer to the mammalian CNS for functional genomic studies

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12 December 2020

Rapid redistribution of the postsynaptic density protein PSD-Zip45 (Homer 1c) and its differential regulation by NMDA receptors and calcium channels.

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12 December 2020

Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression.

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12 December 2020

Targeted retrograde gene delivery for neuronal protection

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12 December 2020

Psychomotor stimulant addiction: a neural systems perspective.

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12 December 2020

Dose and promoter effects of adeno-associated viral vector for green fluorescent protein expression in the rat brain.

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12 December 2020

Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons.

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12 December 2020

An N-terminal sequence specific for a novel Homer1 isoform controls trafficking of group I metabotropic glutamate receptor in mammalian cells

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12 December 2020

Homer regulates gain of ryanodine receptor type 1 channel complex

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12 December 2020

Distribution of cystine/glutamate exchange transporter, system x(c)-, in the mouse brain.

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12 December 2020

Promoters and regulatory elements that improve adeno-associated virus transgene expression in the brain

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12 December 2020

Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse?

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12 December 2020

Excitatory and inhibitory amino acid changes during repeated episodes of ethanol withdrawal: an in vivo microdialysis study

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12 December 2020

Synaptic targeting of PSD-Zip45 (Homer 1c) and its involvement in the synaptic accumulation of F-actin.

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12 December 2020

Development and optimization of adeno-associated virus vector transfer into the central nervous system

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12 December 2020

Alcoholism: allostasis and beyond

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12 December 2020

Effects of acamprosate on excitatory amino acids during multiple ethanol withdrawal periods.

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12 December 2020

Generation and characterization of chimeric recombinant AAV vectors

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12 December 2020

Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons

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12 December 2020

Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior.

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12 December 2020

Viral vectors for gene delivery to the nervous system

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12 December 2020

Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse

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12 December 2020

Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities

1 reference

12 December 2020

Inhibition of dendritic spine morphogenesis and synaptic transmission by activity-inducible protein Homer1a

1 reference

12 December 2020

Vesl/Homer proteins regulate ryanodine receptor type 2 function and intracellular calcium signaling

1 reference

12 December 2020

Recombinant AAV serotype 1 transduction efficiency and tropism in the murine brain

1 reference

12 December 2020

Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 Receptors

1 reference

12 December 2020

Homer1 proteins and AMPA receptors modulate cocaine‐induced behavioural plasticity

1 reference

12 December 2020

PI3 kinase enhancer–Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis

1 reference

12 December 2020

The genetics of adult-onset neuropsychiatric disease: complexities and conundra?

1 reference

12 December 2020

The Homer family and the signal transduction system at glutamatergic postsynaptic density: potential role in behavior and pharmacotherapy

1 reference

12 December 2020

NMDA receptor antagonism and the ethanol intoxication signal: from alcoholism risk to pharmacotherapy

1 reference

12 December 2020

Activity-inducible protein Homer1a/Vesl-1S promotes redistribution of postsynaptic protein Homer1c/Vesl-1L in cultured rat hippocampal neurons

1 reference

12 December 2020

Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampus.

1 reference

12 December 2020

Differential expression of Homer family proteins in the developing mouse brain

1 reference

12 December 2020

Homer proteins regulate sensitivity to cocaine

1 reference

12 December 2020

Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system

1 reference

12 December 2020

Cocaine increases medial prefrontal cortical glutamate overflow in cocaine-sensitized rats: a time course study

1 reference

12 December 2020

Chronic ethanol induces synaptic but not extrasynaptic targeting of NMDA receptors.

1 reference

12 December 2020

PDZ domain proteins of synapses

1 reference

12 December 2020

Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain

1 reference

12 December 2020

Hepatocyte growth factor receptor is a coreceptor for adeno-associated virus type 2 infection.

1 reference

12 December 2020

The interaction of phospholipase C-beta3 with Shank2 regulates mGluR-mediated calcium signal

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12 December 2020

Cytogenetics and gene discovery in psychiatric disorders.

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12 December 2020

AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats.

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12 December 2020

Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission

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12 December 2020

Ethanol exposure decreases glutamate uptake in the nucleus accumbens

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12 December 2020

Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease.

1 reference

12 December 2020

Homer expression in the Xenopus tadpole nervous system

1 reference

12 December 2020

Key role of the postsynaptic density scaffold proteins Shank and Homer in the functional architecture of Ca2+ homeostasis at dendritic spines in hippocampal neurons.

1 reference

12 December 2020

Recombinant adeno-associated viral vectors in the nervous system

1 reference

12 December 2020

Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia.

1 reference

12 December 2020

Homer2 is necessary for EtOH-induced neuroplasticity.

1 reference

12 December 2020

Homer isoforms differentially regulate cocaine-induced neuroplasticity.

1 reference

12 December 2020

A novel role of circadian transcription factor DBP in hippocampal plasticity.

1 reference

12 December 2020

Characterization of adeno-associated virus genomes isolated from human tissues

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12 December 2020

Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population.

1 reference

12 December 2020

Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex function.

1 reference

12 December 2020

Surface clustering of metabotropic glutamate receptor 1 induced by long Homer proteins

1 reference

12 December 2020

Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery to the neonatal mouse brain

1 reference

12 December 2020

Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties.

1 reference

12 December 2020

Synaptic scaffolding protein Homer1a protects against chronic inflammatory pain

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12 December 2020

Complex, multimodal behavioral profile of the Homer1 knockout mouse.

1 reference

12 December 2020

Conditional deletion of hypothalamic Y2 receptors reverts gonadectomy-induced bone loss in adult mice.

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12 December 2020

Cortical mechanisms of cocaine sensitization

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12 December 2020

Adeno-associated virus serotypes: vector toolkit for human gene therapy

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12 December 2020

Differential control of postsynaptic density scaffolds via actin-dependent and -independent mechanisms

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12 December 2020

Homer 1 mediates store- and inositol 1,4,5-trisphosphate receptor-dependent translocation and retrieval of TRPC3 to the plasma membrane.

1 reference

12 December 2020

Signaling proteins in raft-like microdomains are essential for Ca2+ wave propagation in glial cells.

1 reference

12 December 2020

The endocannabinoid system controls key epileptogenic circuits in the hippocampus

1 reference

12 December 2020

Tetrameric hub structure of postsynaptic scaffolding protein homer

1 reference

12 December 2020

Phosphorylation of glutamate receptors: a potential mechanism for the regulation of receptor function and psychostimulant action

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12 December 2020

Airway epithelium directed gene therapy for cystic fibrosis

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12 December 2020

Gene therapy for cystic fibrosis lung disease: current status and future perspectives

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12 December 2020

Chronic alcohol drinking alters neuronal dendritic spines in the brain reward center nucleus accumbens

1 reference

12 December 2020

Accumbens neurochemical adaptations produced by binge-like alcohol consumption.

1 reference

12 December 2020

Homeostatic plasticity during alcohol exposure promotes enlargement of dendritic spines

1 reference

12 December 2020

Aberrant synaptic activation of N-methyl-D-aspartate receptors underlies ethanol withdrawal hyperexcitability.

1 reference

12 December 2020

In vivo regulation of Homer1a expression in the striatum by cocaine.

1 reference

12 December 2020

Adaptive plasticity of NMDA receptors and dendritic spines: implications for enhanced vulnerability of the adolescent brain to alcohol addiction

1 reference

12 December 2020

Ca2+ signaling in microdomains: Homer1 mediates the interaction between RyR2 and Cav1.2 to regulate excitation-contraction coupling

1 reference

12 December 2020

HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth

1 reference

12 December 2020

Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors

1 reference

12 December 2020

Cocaine induces the expression of homer 1b/c, homer 3a/b, and hsp 27 proteins in rat cerebellum.

1 reference

12 December 2020

Hippocampal gene expression profiling reveals the possible involvement of Homer1 and GABA(B) receptors in scopolamine-induced amnesia.

1 reference

12 December 2020

Molecular basis of genetic neuropsychiatric disorders

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12 December 2020

Accumbens Homer2 overexpression facilitates alcohol-induced neuroplasticity in C57BL/6J mice

1 reference

12 December 2020

A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization.

1 reference

12 December 2020

Prenatal stress alters limbo-corticostriatal Homer protein expression.

1 reference

12 December 2020

Dynamic regulation of ryanodine receptor type 1 (RyR1) channel activity by Homer 1

1 reference

12 December 2020

Homers regulate drug-induced neuroplasticity: implications for addiction

1 reference

12 December 2020

Regional differences in the effects of withdrawal from repeated cocaine upon Homer and glutamate receptor expression: a two-species comparison.

1 reference

12 December 2020

AAV8, 9, Rh10, Rh43 vector gene transfer in the rat brain: effects of serotype, promoter and purification method

1 reference

12 December 2020

Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation

1 reference

12 December 2020

Strain differences in alcohol-induced neurochemical plasticity: a role for accumbens glutamate in alcohol intake

1 reference

12 December 2020

NMDA receptors inhibit synapse unsilencing during brain development

1 reference

12 December 2020

AAV vector-mediated RNAi of mutant huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's disease

1 reference

12 December 2020

Select overexpression of homer1a in dorsal hippocampus impairs spatial working memory

1 reference

12 December 2020

A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication

1 reference

12 December 2020

Cloning of adeno-associated virus into pBR322: rescue of intact virus from the recombinant plasmid in human cells

1 reference

12 December 2020

Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector

1 reference

12 December 2020

On the regional distribution of heparan sulfate proteoglycan immunoreactivity in the rat brain.

1 reference

12 December 2020

Acute ethanol increases taurine but neither glutamate nor GABA in the nucleus accumbens of male rats: a microdialysis study

1 reference

12 December 2020

Biphasic effect of ethanol on extracellular accumulation of glutamate in the hippocampus and the nucleus accumbens

1 reference

12 December 2020

Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

1 reference

12 December 2020

Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization.

1 reference

12 December 2020

Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics

1 reference

12 December 2020

Quantitative analysis of the packaging capacity of recombinant adeno-associated virus

1 reference

12 December 2020

Interactions between ethanol and agents that act on the NMDA-type glutamate receptor.

1 reference

12 December 2020

Homer: a protein that selectively binds metabotropic glutamate receptors

1 reference

12 December 2020

Pharmacology and functions of metabotropic glutamate receptors

1 reference

12 December 2020

Comparison of promoter strengths on gene delivery into mammalian brain cells using AAV vectors

1 reference

12 December 2020

Chronic ethanol exposure leads to a selective enhancement of N-methyl-D-aspartate receptor function in cultured hippocampal neurons.

1 reference

12 December 2020

Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes.

1 reference

12 December 2020

Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions

1 reference

12 December 2020

Ibotenic acid lesions of the dorsal prefrontal cortex disrupt the expression of behavioral sensitization to cocaine.

1 reference

12 December 2020

The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants

1 reference

12 December 2020

Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element.

1 reference

12 December 2020

A complex program of striatal gene expression induced by dopaminergic stimulation.

1 reference

12 December 2020

Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptors

1 reference

12 December 2020

Central effects of acamprosate: part 1. Acamprosate blocks the glutamate increase in the nucleus accumbens microdialysate in ethanol withdrawn rats.

1 reference

12 December 2020

Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins

1 reference

12 December 2020

Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors

1 reference

12 December 2020

Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brain.

1 reference

12 December 2020

Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2.

1 reference

12 December 2020

AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infection

1 reference

12 December 2020

10.1097/FBP.0B013E32830C369F

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18690104%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18690104%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

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