MK-2206, an AKT inhibitor, promotes caspase-independent cell death and inhibits leiomyoma growth (Q37240206)

19 August 2017

MK-2206, an AKT inhibitor, promotes caspase-independent cell death and inhibits leiomyoma growth (English)

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19 August 2017

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Debabrata Chakravarti

object named as

Debabrata Chakravarti

6

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Takeshi Kurita

object named as

Takeshi Kurita

4

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author name string

Elizabeth C Sefton

1

1 reference

19 August 2017

Wenan Qiang

2

1 reference

19 August 2017

Vanida Serna

3

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19 August 2017

Jian-Jun Wei

5

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19 August 2017

J Julie Kim

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19 August 2017

language of work or name

English

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publication date

3 September 2013

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19 August 2017

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19 August 2017

154

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19 August 2017

11

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19 August 2017

4046-4057

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describes a project that uses

19 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3800769/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Biomarkers of response to Akt inhibitor MK-2206 in breast cancer

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Inhibition of AKT with the orally active allosteric AKT inhibitor, MK-2206, sensitizes endometrial cancer cells to progestin

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Combination of an allosteric Akt Inhibitor MK-2206 with etoposide or rapamycin enhances the antitumor growth effect in neuroblastoma.

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The estimated annual cost of uterine leiomyomata in the United States

6 September 2017

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The Akt inhibitor MK2206 synergizes, but perifosine antagonizes, the BRAF(V600E) inhibitor PLX4032 and the MEK1/2 inhibitor AZD6244 in the inhibition of thyroid cancer cells

6 September 2017

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eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206.

6 September 2017

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Combination treatment with MEK and AKT inhibitors is more effective than each drug alone in human non-small cell lung cancer in vitro and in vivo

6 September 2017

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6 September 2017

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6 September 2017

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Progestins activate the AKT pathway in leiomyoma cells and promote survival.

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Requirements of phosphatidylinositol-3 kinase and mammalian target of rapamycin for estrogen-induced proliferation in uterine leiomyoma- and myometrium-derived cell lines

6 September 2017

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Karyotypic characteristics of human uterine leiomyoma and myometrial cell lines following telomerase induction

14 September 2017

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14 September 2017

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14 September 2017

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LC3 and p62 as diagnostic markers of drug-induced autophagic vacuolar cardiomyopathy: a study of 3 cases

28 September 2017

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Gene and protein expression of progesterone receptor isoforms A and B, p53 and p21 in myometrium and uterine leiomyoma.

26 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800769

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3 September 2018

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3 September 2018

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Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model

3 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800769

Expression of insulin-like growth factors (IGFs) and IGF signaling: molecular complexity in uterine leiomyomas.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800769

Health care resource use for uterine fibroid tumors in the United States.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800769

Expression profile of tuberin and some potential tumorigenic factors in 60 patients with uterine leiomyomata

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800769

Role of Akt signaling in mitochondrial survival pathway triggered by hypoxic preconditioning

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800769

Differential expression of Akt/protein kinase B, Bcl-2 and Bax proteins in human leiomyoma and myometrium

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3800769

The frequency of uterine leiomyomas

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24002033

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Phosphorylation of PTEN (phosphatase and tensin homologue deleted on chromosome ten) protein is enhanced in human fibromyomatous uteri

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24002033

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1210/EN.2013-1389

1 reference

19 August 2017

1 reference

19 August 2017

PubMed publication ID

24002033

1 reference