Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice. (Q37245689)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17960025%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

title

Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice (English)

1 reference

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9 January 2020

1 reference

10

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9 January 2020

Marcia L E MacDonald

1

1 reference

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9 January 2020

Roshni Singaraja

2

1 reference

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9 January 2020

William T. Gibson

7

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9 January 2020

Michael R. Hayden

11

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9 January 2020

author name string

Nagat Bissada

3

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9 January 2020

Piers Ruddle

4

1 reference

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9 January 2020

Russell Watts

5

1 reference

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9 January 2020

Joanna M Karasinska

6

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9 January 2020

Catherine Fievet

8

1 reference

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9 January 2020

Jean E Vance

9

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9 January 2020

publication date

24 October 2007

1 reference

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Journal of Lipid Research

9 January 2020

published in

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9 January 2020

volume

49

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9 January 2020

issue

1

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9 January 2020

page(s)

217-229

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Obesity, Inflammation, and Insulin Resistance

9 January 2020

cites work

1 reference

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Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice

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Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet

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Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation

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Gene expression profiling in skeletal muscle of Zucker diabetic fatty rats: implications for a role of stearoyl-CoA desaturase 1 in insulin resistance

9 September 2017

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Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans

9 September 2017

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A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria

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Should nonalcoholic fatty liver disease be renamed?

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Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates

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Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

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Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells

9 September 2017

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Quantitative body composition analysis in awake mice and rats by magnetic resonance relaxometry

9 September 2017

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Control of glycaemia: from molecules to men. Minkowski Lecture 2003.

9 September 2017

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Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver.

9 September 2017

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LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1

9 September 2017

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Protein measurement with the Folin phenol reagent

9 September 2017

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A major health hazard: the metabolic syndrome

9 September 2017

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Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors

9 September 2017

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Role of stearoyl-coenzyme A desaturase in lipid metabolism

9 September 2017

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Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia

9 September 2017

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Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity

9 September 2017

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Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss

9 September 2017

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Synthetic LXR ligand inhibits the development of atherosclerosis in mice

9 September 2017

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

9 September 2017

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Importance of HDL cholesterol levels and the total/ HDL cholesterol ratio as a risk factor for coronary heart disease in molecularly defined heterozygous familial hypercholesterolaemia

9 September 2017

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Relationship of dietary fat and serum cholesterol ester and phospholipid fatty acids to markers of insulin resistance in men and women with a range of glucose tolerance

9 September 2017

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Scd3--a novel gene of the stearoyl-CoA desaturase family with restricted expression in skin

9 September 2017

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Role of LXRs in control of lipogenesis

9 September 2017

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Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes.

9 September 2017

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The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1

9 September 2017

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Asebia-2J (Scd1(ab2J)): a new allele and a model for scarring alopecia

9 September 2017

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Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol

9 September 2017

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Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites

9 September 2017

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Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation

9 September 2017

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Skeletal muscle membrane lipid composition is related to adiposity and insulin action

9 September 2017

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Abnormal splicing of the leptin receptor in diabetic mice

9 September 2017

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Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery

9 September 2017

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Fatty acid synthesis and its regulation

9 September 2017

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The genetics of diabetes susceptibility in mice

9 September 2017

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Fatty acid synthase, a proficient multifunctional enzyme

9 September 2017

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Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase

9 September 2017

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Molecular genetics of the LDL receptor gene in familial hypercholesterolemia

9 September 2017

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Increased ABCA1 activity protects against atherosclerosis.

9 September 2017

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Identification and characterization of a novel gene disrupted by a pericentric inversion inv(4)(p13.1q21.1) in a family with cleft lip.

14 September 2017

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Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure

14 September 2017

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Unsaturated fatty acids inhibit cholesterol efflux from macrophages by increasing degradation of ATP-binding cassette transporter A1.

14 September 2017

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Gene-environment interactions in the pathogenesis of type 2 diabetes mellitus: lessons learned from the Pima Indians

28 September 2017

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28 September 2017

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28 September 2017

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Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate

26 June 2018

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Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-ric

26 June 2018

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26 June 2018

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26 June 2018

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Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase

26 June 2018

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Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1-/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation.

26 June 2018

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Fatty acid composition of serum lipids predicts the development of the metabolic syndrome in men.

3 September 2018

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Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma

3 September 2018

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Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver

3 September 2018

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Macrophage liver X receptor is required for antiatherogenic activity of LXR agonists

3 September 2018

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Scd1ab-Xyk: a new asebia allele characterized by a CCC trinucleotide insertion in exon 5 of the stearoyl-CoA desaturase 1 gene in mouse

3 September 2018

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Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha.

3 September 2018

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Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms

3 September 2018

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Evidence that the anti-obesity effect of conjugated linoleic acid is independent of effects on stearoyl-CoA desaturase1 expression and enzyme activity

3 September 2018

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Genetic background selectively influences innominate artery atherosclerosis: immune system deficiency as a probe

3 September 2018

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T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice

3 September 2018

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A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

3 September 2018

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Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol

3 September 2018

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Polyunsaturated fatty acids and acetoacetate downregulate the expression of the ATP-binding cassette transporter A1.

3 September 2018

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Obesity, metabolic syndrome, and coronary atherosclerosis.

3 September 2018

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ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation

3 September 2018

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LDL receptor but not apolipoprotein E deficiency increases diet-induced obesity and diabetes in mice

3 September 2018

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Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid.

3 September 2018

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A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis

3 September 2018

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Cloning and characterization of the human stearoyl-CoA desaturase gene promoter: transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterol

3 September 2018

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Association of nonalcoholic fatty liver disease with insulin resistance.

3 September 2018

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Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse.

3 September 2018

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Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites

3 September 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700478-JLR200

Increased ABCA1 activity protects against atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700478-JLR200

Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700478-JLR200

Influence of HDL Cholesterol on Preclinical Carotid Atherosclerosis in Familial Hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M700478-JLR200

Diet-Induced Increases in Adiposity, but Not Plasma Lipids, Promote Macrophage Infiltration Into White Adipose Tissue

21 January 2018

1 reference

12 December 2020

Stearoyl-CoA Desaturase-1 Mediates the Pro-lipogenic Effects of Dietary Saturated Fat

1 reference

12 December 2020

Decreased Susceptibility to Diet-Induced Atherosclerosis in Human Apolipoprotein A-II Transgenic Mice

1 reference

12 December 2020

Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice

1 reference

12 December 2020

Metabolic syndrome and risk of coronary, cerebral, and peripheral vascular disease in a large Dutch population with familial hypercholesterolemia

1 reference

12 December 2020

Coronary artery disease in heterozygous familial hypercholesterolemia

1 reference

12 December 2020

Skin Lipids of a Normal and a Mutant (Asebic) Mouse Strain*

1 reference

12 December 2020

Fatty acid composition of adipose tissue in normal, atherosclerotic and diabetic subjects

1 reference

12 December 2020

Lipid homeostasis and lipoprotein secretion in Niemann-Pick C1-deficient hepatocytes

1 reference

12 December 2020

Genetic and environmental factors affecting the incidence of coronary artery disease in heterozygous familial hypercholesterolemia

1 reference

12 December 2020

Coronary Artery Disease in Heterozygous Familial Hypercholesterolemia Patients With the Same LDL Receptor Gene Mutation

1 reference

12 December 2020

Characteristics of coronary artery disease and lipoprotein abnormalities in patients with heterozygous familial hypercholesterolemia associated with diabetes mellitus or impaired glucose tolerance

1 reference

12 December 2020

Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women

1 reference

12 December 2020

Oxidized Fatty Acids Promote Atherosclerosis Only in the Presence of Dietary Cholesterol in Low-Density Lipoprotein Receptor Knockout Mice

1 reference

12 December 2020

Serum fatty acids and blood pressure

1 reference

12 December 2020

10.1194/JLR.M700478-JLR200

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17960025%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17960025%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

17960025

1 reference