EMT and proteinuria as progression factors (Q37248336)

19 August 2017

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title

EMT and proteinuria as progression factors (English)

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19 August 2017

Frank M Strutz

1

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PubMed ID

18716603

19 August 2017

language of work or name

English

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publication date

20 August 2008

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19 August 2017

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19 August 2017

75

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19 August 2017

475-481

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19 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/ki.2008.425

19 August 2017

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How does proteinuria cause progressive renal damage?

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Tubular catabolism of albumin is associated with the release of an inflammatory lipid

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Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kappa B activation.

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Protein overload induces fractalkine upregulation in proximal tubular cells through nuclear factor kappaB- and p38 mitogen-activated protein kinase-dependent pathways

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Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy

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Evidence that fibroblasts derive from epithelium during tissue fibrosis

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Interstitial fibrosis in mice with overload proteinuria: Deficiency of TIMP-1 is not protective

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Remodeling of renal interstitial and tubular lesions in pancreas transplant recipients

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7 January 2021

Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Reversal of Glomerulosclerosis after High-Dose Enalapril Treatment in Subtotally Nephrectomized Rats

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7 January 2021

Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7).

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https://api.crossref.org/works/10.1038%2FKI.2008.425

7 January 2021

BMP 7 is required for nephrogenesis, eye development, and skeletal patterning

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https://api.crossref.org/works/10.1038%2FKI.2008.425

7 January 2021

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning

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https://api.crossref.org/works/10.1038%2FKI.2008.425

7 January 2021

BMP7 antagonizes TGF-beta -dependent fibrogenesis in mesangial cells

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https://api.crossref.org/works/10.1038%2FKI.2008.425

7 January 2021

Functional characterization of bone morphogenetic protein binding sites and Smad1/5 activation in human vascular cells

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https://api.crossref.org/works/10.1038%2FKI.2008.425

7 January 2021

Gene expression profiles of human proximal tubular epithelial cells in proteinuric nephropathies.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2008.425

7 January 2021

Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease

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https://api.crossref.org/works/10.1038%2FKI.2008.425

7 January 2021

Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease

1 reference

https://api.crossref.org/works/10.1038%2FKI.2008.425

7 January 2021

Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FKI.2008.425

7 January 2021

Inhibition of endogenous BMP in the glomerulus leads to mesangial matrix expansion

1 reference

https://api.crossref.org/works/10.1038%2FKI.2008.425

7 January 2021

Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2008.425

7 January 2021

Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models

1 reference

https://api.crossref.org/works/10.1038%2FKI.2008.425

7 January 2021

BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury

1 reference

https://api.crossref.org/works/10.1038%2FKI.2008.425

7 January 2021

Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FKI.2008.425

7 January 2021

Bone morphogenetic protein-7 inhibits constitutive and interleukin-1 beta-induced monocyte chemoattractant protein-1 expression in human mesangial cells: role for JNK/AP-1 pathway

1 reference

https://api.crossref.org/works/10.1038%2FKI.2008.425

7 January 2021

BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2008.425

7 January 2021

Identifiers

DOI

10.1038/KI.2008.425

1 reference

19 August 2017

1 reference

PubMed ID

18716603