Phosphorylation of IRS proteins, insulin action, and insulin resistance (Q37252616)

19 August 2017

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title

Phosphorylation of IRS proteins, insulin action, and insulin resistance (English)

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19 August 2017

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Sigalit Boura-Halfon

1

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PubMed ID

18728222

19 August 2017

Yehiel Zick

series ordinal

2

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19 August 2017

26 August 2008

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American Journal of Physiology - Endocrinology and Metabolism

19 August 2017

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19 August 2017

296

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19 August 2017

E581-91

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19 August 2017

4

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The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

19 August 2017

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Cross-talk between skeletal muscle and adipose tissue: a link with obesity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

IKK-beta links inflammation to obesity-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Evidence for involvement of protein kinase C (PKC)-zeta and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Activation of protein kinase C zeta induces serine phosphorylation of VAMP2 in the GLUT4 compartment and increases glucose transport in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

The phosphoinositide 3-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Role of glycogen synthase kinase-3 alpha in insulin action in cultured human skeletal muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

21 January 2018

The renaissance of GSK3

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

SIK2 can be activated by deprivation of nutrition and it inhibits expression of lipogenic genes in adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Function and dysfunction of aPKC isoforms for glucose transport in insulin-sensitive and insulin-resistant states

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Atypical protein kinase C in insulin action and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Phosphorylation of Irs1 at SER-522 inhibits insulin signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

PKCdelta-mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Positive and negative regulation of glucose uptake by hyperosmotic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Time-dependent effects of fatty acids on skeletal muscle metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

A central role for JNK in obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Chronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Mechanisms linking obesity to insulin resistance and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Signal integration and the specificity of insulin action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute [...]

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

PKC-theta knockout mice are protected from fat-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Prevention of fat-induced insulin resistance by salicylate

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Nutrient-induced insulin resistance in human skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Recent advances in our understanding of insulin action and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Protein kinase Czeta mediates insulin-induced glucose transport through actin remodeling in L6 muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Phosphorylation of human insulin receptor substrate-1 at Serine 629 plays a positive role in insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Myosin motor Myo1c and its receptor NEMO/IKK-gamma promote TNF-alpha-induced serine307 phosphorylation of IRS-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Interaction between the insulin receptor and its downstream effectors. Use of individually expressed receptor domains for structure/function analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Differential effects of tumor necrosis factor-alpha on protein kinase C isoforms alpha and delta mediate inhibition of insulin receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Insulin signalling and the regulation of glucose and lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Specific protein kinase C isoforms as transducers and modulators of insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Transgenic mice with dominant negative PKC-theta in skeletal muscle: a new model of insulin resistance and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Sequential phosphorylation of insulin receptor substrate-2 by glycogen synthase kinase-3 and c-Jun NH2-terminal kinase plays a role in hepatic insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Inflammation and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

In vitro phosphorylation of insulin receptor substrate 1 by protein kinase C-zeta: functional analysis and identification of novel phosphorylation sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Tyrosine phosphorylation of insulin receptor substrate-1 in vivo depends upon the presence of its pleckstrin homology region

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Inflammation, stress, and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Regulation of insulin receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

Global Assessment of Regulation of Phosphorylation of Insulin Receptor Substrate-1 by Insulin In Vivo in Human Muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90437.2008

10.1152/AJPENDO.90437.2008

21 January 2018

Identifiers

DOI

1 reference

19 August 2017

1 reference

PubMed ID

18728222