A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy. (Q37254027)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19439414%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

title

A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy (English)

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28 January 2020

1

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28 January 2020

5

Michael J Ackerman

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28 January 2020

author name string

Michelle S Parvatiyar

2

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28 January 2020

Michelle A Jones

3

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28 January 2020

Jingsheng Liang

4

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28 January 2020

James D Potter

6

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28 January 2020

language of work or name

English

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publication date

12 May 2009

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28 January 2020

number of pages

11

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Journal of Biological Chemistry

inferred from page(s)

published in

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28 January 2020

volume

284

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28 January 2020

issue

28

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28 January 2020

page(s)

19090-19100

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Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice.

28 January 2020

cites work

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First mutation in cardiac troponin C, L29Q, in a patient with hypertrophic cardiomyopathy

6 September 2017

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Familial hypertrophic cardiomyopathy mutations in the regulatory light chains of myosin affect their structure, Ca2+ binding, and phosphorylation

6 September 2017

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Mutations in the N- and D-helices of the N-domain of troponin C affect the C-domain and regulatory function

6 September 2017

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Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution

6 September 2017

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Structural details of a calcium-induced molecular switch: X-ray crystallographic analysis of the calcium-saturated N-terminal domain of troponin C at 1.75 A resolution

6 September 2017

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6 September 2017

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The effects of N helix deletion and mutant F29W on the Ca2+ binding and functional properties of chicken skeletal muscle troponin

6 September 2017

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6 September 2017

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6 September 2017

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26 June 2018

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Calmidazolium, a calmodulin antagonist, stimulates calcium-troponin C and calcium-calmodulin-dependent activation of striated muscle myofilaments

26 June 2018

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26 June 2018

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26 June 2018

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26 June 2018

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Challenging current paradigms related to cardiomyopathies. Are changes in the Ca2+ sensitivity of myofilaments containing cardiac troponin C mutations (G159D and L29Q) good predictors of the phenotypic outcomes?

26 June 2018

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3 September 2018

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Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility

3 September 2018

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Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments

3 September 2018

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Cardiac troponin C-L29Q, related to hypertrophic cardiomyopathy, hinders the transduction of the protein kinase A dependent phosphorylation signal from cardiac troponin I to C.

3 September 2018

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3 September 2018

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Prevalence and spectrum of thin filament mutations in an outpatient referral population with hypertrophic cardiomyopathy

3 September 2018

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Molecular genetic basis of hypertrophic cardiomyopathy: genetic markers for sudden cardiac death

3 September 2018

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Steric-model for activation of muscle thin filaments 1 1 Edited by P.E. Wright

3 September 2018

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Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.007021

The role of the four Ca2+ binding sites of troponin C in the regulation of skeletal muscle contraction

21 January 2018

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12 December 2020

Fluorescent probes attached to Cys 35 or Cys 84 in cardiac troponin C are differentially sensitive to Ca(2+)-dependent events in vitro and in situ

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12 December 2020

Introduction of negative charge mimicking protein kinase C phosphorylation of cardiac troponin I. Effects on cardiac troponin C

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12 December 2020

The role of electrostatics in the interaction of the inhibitory region of troponin I with troponin C

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12 December 2020

An interplay between protein disorder and structure confers the Ca2+ regulation of striated muscle

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12 December 2020

The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation

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12 December 2020

Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy

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12 December 2020

Mapping the interacting regions between troponins T and C. Binding of TnT and TnI peptides to TnC and NMR mapping of the TnT-binding site on TnC

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12 December 2020

Structure of the Mg2+-loaded C-lobe of cardiac troponin C bound to the N-domain of cardiac troponin I: comparison with the Ca2+-loaded structure

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12 December 2020

Refinement of the structure of carp muscle calcium-binding parvalbumin by model building and difference fourier analysis

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12 December 2020

The calcium and magnesium binding sites on cardiac troponin and their role in the regulation of myofibrillar adenosine triphosphatase

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12 December 2020

A structural role for the Ca2+-Mg2+ sites on troponin C in the regulation of muscle contraction. Preparation and properties of troponin C depleted myofibrils

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12 December 2020

Structure of the calcium regulatory muscle protein troponin-C at 2.8 Å resolution

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12 December 2020

Stimulation of cardiac myofilament force, ATPase activity and troponin C Ca++ binding by bepridil

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12 December 2020

Effect of rigor and cycling cross-bridges on the structure of troponin C and on the Ca2+ affinity of the Ca2+-specific regulatory sites in skinned rabbit psoas fibers

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12 December 2020

Reciprocal coupling between troponin C and myosin crossbridge attachment

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12 December 2020

Conformational changes in the metal-binding sites of cardiac troponin C induced by calcium binding

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12 December 2020

A direct regulatory role for troponin T and a dual role for troponin C in the Ca2+ regulation of muscle contraction

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12 December 2020

Relationship between stability and function for isolated domains of troponin C

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12 December 2020

Identifiers

DOI

10.1074/JBC.M109.007021

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19439414%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19439414%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

1 reference