Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis (Q37280613)

19 August 2017

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title

Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis (English)

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19 August 2017

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Maripat Corr

1

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19 August 2017

1 October 2008

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Nature Clinical Practice Rheumatology

19 August 2017

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19 August 2017

4

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19 August 2017

10

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19 August 2017

550-556

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https://scigraph.springernature.com/pub.10.1038/ncprheum0904

19 August 2017

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Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton

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Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation

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High bone density due to a mutation in LDL-receptor-related protein 5

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Identification and structure of the anti-sigma factor-binding domain of the disulphide-stress regulated sigma factor sigma(R) from Streptomyces coelicolor

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Correlation of expression of Wnt-1 in developing limbs with abnormalities in growth and skeletal patterning

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7 January 2021

Inhibition of chondrogenesis by Wnt gene expression in vivo and in vitro.

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7 January 2021

Involvement of Wnt-5a in chondrogenic pattern formation in the chick limb bud.

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7 January 2021

Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation

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Long-term in vitro analysis of limb cartilage development: involvement of Wnt signaling

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Wnt-7a causes loss of differentiated phenotype and inhibits apoptosis of articular chondrocytes via different mechanisms

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7 January 2021

Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis

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A new member of the frizzled family from Drosophila functions as a Wingless receptor

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A frizzled homolog functions in a vertebrate Wnt signaling pathway

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The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

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Identification of c-MYC as a target of the APC pathway

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Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway

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7 January 2021

Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells

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Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development

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Antagonistic regulation of convergent extension movements in Xenopus by Wnt/beta-catenin and Wnt/Ca2+ signaling.

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Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

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The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3

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Functional interaction of beta-catenin with the transcription factor LEF-1

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7 January 2021

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

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A new secreted protein that binds to Wnt proteins and inhibits their activities

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7 January 2021

The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals

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7 January 2021

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

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7 January 2021

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

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7 January 2021

The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling

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7 January 2021

Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling

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7 January 2021

Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

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7 January 2021

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

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7 January 2021

Osteoarthritis-susceptibility locus on chromosome 11q, detected by linkage.

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7 January 2021

Finer linkage mapping of primary hip osteoarthritis susceptibility on chromosome 11q in a cohort of affected female sibling pairs

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7 January 2021

Q89R polymorphism in the LDL receptor-related protein 5 gene is associated with spinal osteoarthritis in postmenopausal Japanese women.

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7 January 2021

Haplotypes of the low-density lipoprotein receptor-related protein 5 (LRP5) gene: Are they a risk factor in osteoarthritis?

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7 January 2021

Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.

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7 January 2021

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7 January 2021

Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites

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7 January 2021

Sex and ethnic differences in the association ofASPN,CALM1,COL2A1,COMP, andFRZB with genetic susceptibility to osteoarthritis of the knee

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7 January 2021

Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-beta/bone morphogenic protein signalling

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https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Expression and function of wingless and frizzled homologs in rheumatoid arthritis.

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https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Differential expression of WNTs and FRPs in the synovium of rheumatoid arthritis and osteoarthritis

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https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Beta-catenin regulates expression of cyclooxygenase-2 in articular chondrocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Regulation of beta-catenin signaling and maintenance of chondrocyte differentiation by ubiquitin-independent proteasomal degradation of alpha-catenin.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Alteration of matrix glycosaminoglycans diminishes articular chondrocytes' response to a canonical Wnt signal

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Regulation of the chondrocyte phenotype by beta-catenin

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Axin1 and Axin2 are regulated by TGF- and mediate cross-talk between TGF- and Wnt signaling pathways.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Beta-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

1,25-Dihydroxyvitamin D3 induces expression of the Wnt signaling co-regulator LRP5 via regulatory elements located significantly downstream of the gene's transcriptional start site

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Dickkopf-1 is a master regulator of joint remodeling

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Frzb-1, an antagonist of Wnt-1 and Wnt-8, does not block signaling by Wnts -3A, -5A, or -11.

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0904

7 January 2021

Identifiers

DOI

10.1038/NCPRHEUM0904

1 reference

PubMed ID

18820702

Dimensions Publication ID

19 August 2017

0 references

1 reference

PubMed ID

18820702