Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons. (Q37316706)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27716410%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

title

Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons (English)

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25 March 2020

1 reference

3

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25 March 2020

Jenny M. Gunnersen

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25 March 2020

Hiroshi Takeshima

6

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25 March 2020

Iryna Voytyuk

8

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25 March 2020

Mikail D Levasseur

10

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25 March 2020

Stephan A Müller

12

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25 March 2020

Stefan F Lichtenthaler

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25 March 2020

author name string

Martina Pigoni

1

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25 March 2020

Johanna Wanngren

2

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25 March 2020

Kathryn M Munro

4

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25 March 2020

Regina Feederle

7

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25 March 2020

Brian J Hrupka

11

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25 March 2020

Bart De Strooper

9

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25 March 2020

publication date

5 October 2016

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Molecular Neurodegeneration

25 March 2020

published in

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25 March 2020

volume

11

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25 March 2020

issue

1

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25 March 2020

page(s)

67

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The amyloid hypothesis of Alzheimer's disease at 25 years

25 March 2020

cites work

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6 September 2017

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6 September 2017

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Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease

6 September 2017

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β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects

6 September 2017

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Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines

6 September 2017

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Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

6 September 2017

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The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo

6 September 2017

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Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor

6 September 2017

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The Role of Seizure-Related SEZ6 as a Susceptibility Gene in Febrile Seizures

6 September 2017

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Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing

6 September 2017

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Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP

6 September 2017

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The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex

6 September 2017

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Di-substituted pyridinyl aminohydantoins as potent and highly selective human beta-secretase (BACE1) inhibitors

6 September 2017

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Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements

6 September 2017

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Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

6 September 2017

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Sez-6 proteins affect dendritic arborization patterns and excitability of cortical pyramidal neurons

6 September 2017

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6 September 2017

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Febrile seizures are associated with mutation of seizure-related (SEZ) 6, a brain-specific gene

6 September 2017

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6 September 2017

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Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family

6 September 2017

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6 September 2017

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6 September 2017

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Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases

6 September 2017

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

6 September 2017

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

6 September 2017

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

6 September 2017

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

6 September 2017

1 reference

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Cloning and expression of SEZ-6, a brain-specific and seizure-related cDNA.

6 September 2017

1 reference

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Continuous cultures of fused cells secreting antibody of predefined specificity

6 September 2017

1 reference

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Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.

6 September 2017

1 reference

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Cell type- and brain region-resolved mouse brain proteome.

14 September 2017

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Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse

14 September 2017

1 reference

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The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

14 September 2017

1 reference

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Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

14 September 2017

1 reference

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The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

14 September 2017

1 reference

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Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles

14 September 2017

1 reference

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Unsaturated fatty acids drive disintegrin and metalloproteinase (ADAM)-dependent cell adhesion, proliferation, and migration by modulating membrane fluidity

26 June 2018

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A technique for serial collection of cerebrospinal fluid from the cisterna magna in mouse

26 June 2018

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Enhanced SDC-assisted digestion coupled with lipid chromatography-tandem mass spectrometry for shotgun analysis of membrane proteome

26 June 2018

1 reference

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Improvement of a sample preparation method assisted by sodium deoxycholate for mass-spectrometry-based shotgun membrane proteomics

2 September 2018

1 reference

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QARIP: a web server for quantitative proteomic analysis of regulated intramembrane proteolysis

2 September 2018

1 reference

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Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053352

Polymorphisms in seizure 6-like gene are associated with bipolar disorder I: evidence of gene × gender interaction

2 September 2018

1 reference

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BACE1 gene deletion: impact on behavioral function in a model of Alzheimer's disease.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053352

Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC.

2 September 2018

1 reference

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Bace1 modulates myelination in the central and peripheral nervous system.

2 September 2018

1 reference

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Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053352

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053352

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5053352

10.1186/S13024-016-0134-Z

2 September 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27716410%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

25 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27716410%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

PubMed publication ID

27716410

1 reference