The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. (Q40106778)

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English	The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.	scientific article

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2 January 2020

The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice (English)

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2 January 2020

electrophysiology

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Jochen Herms

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2 January 2020

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Sabine Ring

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Sascha W Weyer

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Susanne B Kilian

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Elaine Waldron

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Claus U Pietrzik

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2 January 2020

Mikhail A Filippov

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2 January 2020

Christian Buchholz

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Christopher B Eckman

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Martin Korte

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David P Wolfer

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2 January 2020

Ulrike C Müller

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1 July 2007

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2 January 2020

Journal of Neuroscience

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7817-7826

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2 January 2020

Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor protein

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https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice.

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https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein

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https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

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Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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Reduced cerebrospinal fluid levels of alpha-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Levels of alpha- and beta-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

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https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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[alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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alpha- and beta-secretase: profound changes in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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APP processing and synaptic function

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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Impaired explorative behavior and neophobia in genetically modified mice lacking or overexpressing the extracellular serine protease inhibitor neuroserpin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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Inhibition of Receptor-mediated Endocytosis Demonstrates Generation of Amyloid β-Protein at the Cell Surface

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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A secreted form of the beta-amyloid precursor protein (sAPP695) improves spatial recognition memory in OF1 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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The amyloid-beta precursor protein: integrating structure with biological function

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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Synapse Formation and Function Is Modulated by the Amyloid Precursor Protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid precursor protein: beyond amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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The functions of mammalian amyloid precursor protein and related amyloid precursor-like proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADAM-10 over-expression increases cortical synaptogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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Behavioral symptoms in Alzheimer's disease: phenomenology and treatment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased alpha-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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Increase in extracellular NCAM and amyloid precursor protein following induction of long-term potentiation in the dentate gyrus of anaesthetized rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrospinal fluid levels of alpha-secretase-cleaved soluble amyloid precursor protein mirror cognition in a Swedish family with Alzheimer disease and a gene mutation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified beta-amyloid precursor protein gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

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Identifiers

10.1523/JNEUROSCI.1026-07.2007

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2 January 2020

1 reference

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2 January 2020

1 reference

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2 January 2020

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