Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin (Q37323331)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18442998%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

title

Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin (English)

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6 January 2020

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6 January 2020

author name string

Yuexia Wang

1

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6 January 2020

David M Owens

3

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6 January 2020

Karima Djabali

4

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6 January 2020

Colin L Stewart

5

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6 January 2020

Howard J Worman

6

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6 January 2020

publication date

28 April 2008

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6 January 2020

published in

Human Molecular Genetics

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6 January 2020

volume

17

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6 January 2020

issue

15

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6 January 2020

page(s)

2357-2369

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describes a project that uses

6 January 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

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Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation.

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Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody

6 September 2017

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Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis

6 September 2017

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Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome

6 September 2017

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Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

6 September 2017

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Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

6 September 2017

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Dermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stress

6 September 2017

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Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

6 September 2017

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Cellular and molecular facets of keratinocyte reepithelization during wound healing.

6 September 2017

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Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice

6 September 2017

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Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy

6 September 2017

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Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome

6 September 2017

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A lamin A/C beta-strand containing the site of lipodystrophy mutations is a major surface epitope for a new panel of monoclonal antibodies

6 September 2017

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Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice

6 September 2017

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Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

6 September 2017

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6 September 2017

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Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.

6 September 2017

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6 September 2017

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Progeria infantum (Hutchinson-Gilford syndrome) associated with scleroderma-like lesions and acro-osteolysis: a case report and brief review of the literature

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Of mice and men: genetic skin diseases of keratin

6 September 2017

1 reference

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Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition

6 September 2017

1 reference

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Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24

14 September 2017

1 reference

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LMNA is mutated in Hutchinson-Gilford progeria (MIM 176670) but not in Wiedemann-Rautenstrauch progeroid syndrome (MIM 264090).

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733813

The Hutchinson-Gilford progeria syndrome. Report of 4 cases and review of the literature

14 September 2017

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Analysis of cultured keratinocytes from a transgenic mouse model of psoriasis: effects of suprabasal integrin expression on keratinocyte adhesion, proliferation and terminal differentiation

14 September 2017

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Towards a molecular definition of keratinocyte activation after acute injury to stratified epithelia

28 September 2017

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Progeria (Hutchinson-Gilford).

26 June 2018

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Isoprenylation is required for the processing of the lamin A precursor

26 June 2018

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Progressive Early Dermatologic Changes in Hutchinson-Gilford Progeria Syndrome

26 June 2018

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Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference

26 June 2018

1 reference

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Expression of an LMNA-N195K variant of A-type lamins results in cardiac conduction defects and death in mice.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733813

Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733813

Lamin A expression levels are unperturbed at the normal and mutant alleles but display partial splice site selection in Hutchinson-Gilford progeria syndrome

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733813

Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733813

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733813

The nuclear envelope lamina is reversibly depolymerized during mitosis

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733813

Intracellular trafficking of emerin, the Emery-Dreifuss muscular dystrophy protein

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733813

Pathology and nuclear abnormalities in hearts of transgenic mice expressing M371K lamin A encoded by an LMNA mutation causing Emery-Dreifuss muscular dystrophy

20 October 2018

1 reference

12 December 2020

Mouse model carrying H222P- Lmna mutation develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies

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12 December 2020

The nuclear lamina is a meshwork of intermediate-type filaments

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12 December 2020

A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis

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12 December 2020

Development, characterization, and wound healing of the keratin 14 promoted transforming growth factor-beta1 transgenic mouse

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12 December 2020

Properties of lamin A mutants found in Emery-Dreifuss muscular dystrophy, cardiomyopathy and Dunnigan-type partial lipodystrophy

1 reference

12 December 2020

Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease

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12 December 2020

Expression of involucrin in normal, hyperproliferative and neoplastic mouse keratinocytes

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12 December 2020

Identifiers

DOI

10.1093/HMG/DDN136

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18442998%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18442998%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

PubMed publication ID

18442998

1 reference