Reflecting on 25 years with MYC. (Q37333643)

19 August 2017

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title

Reflecting on 25 years with MYC. (English)

1 reference

19 August 2017

Natalie Meyer

1

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PubMed ID

19029958

19 August 2017

Linda Z Penn

series ordinal

2

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PubMed ID

19029958

19 August 2017

language of work or name

English

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publication date

1 December 2008

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19 August 2017

Nature Reviews Cancer

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19 August 2017

8

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19 August 2017

12

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19 August 2017

976-990

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https://scigraph.springernature.com/pub.10.1038/nrc2231

19 August 2017

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Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma

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Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line

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Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

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Transposition and amplification of oncogene-related sequences in human neuroblastomas

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Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma

31 March 2020

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Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage

31 March 2020

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L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer

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Myc oncogene: a key component in cell cycle regulation and its implication for lung cancer

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Amplification and Overexpression of the L-MYC Proto-Oncogene in Ovarian Carcinomas

31 March 2020

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Nuclear location of the putative transforming protein of avian myelocytomatosis virus

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Nuclear localization and DNA binding of the transforming gene product of avian myelocytomatosis virus

31 March 2020

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Proteins encoded by v-myc and c-myc oncogenes: Identification and localization in acute leukemia virus transformants and bursal lymphoma cell lines

31 March 2020

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Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

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Extreme instability of myc mRNA in normal and transformed human cells.

31 March 2020

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Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells

31 March 2020

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c-myc oncogene protein synthesis is independent of the cell cycle in human and avian cells

31 March 2020

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Levels of c-myc oncogene mRNA are invariant throughout the cell cycle

31 March 2020

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Expression of c-myc changes during differentiation of mouse erythroleukaemia cells.

31 March 2020

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Expression of myb, myc and fos proto-oncogenes during the differentiation of a murine myeloid leukaemia

31 March 2020

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Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation

31 March 2020

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myc function and regulation

31 March 2020

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The human c-myc oncogene: structural consequences of translocation into the IgH locus in Burkitt lymphoma

31 March 2020

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The structure and nucleotide sequence of the 5' end of the human c-myc oncogene

31 March 2020

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A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells

31 March 2020

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Contributions of transcriptional and post-transcriptional mechanisms to the regulation of c-myc expression in mouse erythroleukemia cells

31 March 2020

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Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in Burkitt lymphoma.

31 March 2020

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How the c-myc promoter works and why it sometimes does not.

31 March 2020

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Sequence requirements for premature termination of transcription in the human c-myc gene

31 March 2020

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Transcriptional arrest within the first exon is a fast control mechanism in c-myc gene expression

31 March 2020

1 reference

The c-myc promoter: still MysterY and challenge

31 March 2020

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Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-alpha responsive promoters.

31 March 2020

1 reference

Differential complementation of Bcr-Abl point mutants with c-Myc

31 March 2020

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Identification of c-MYC as a target of the APC pathway

31 March 2020

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The myc oncogene: MarvelouslY Complex

31 March 2020

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Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling

31 March 2020

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Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src.

31 March 2020

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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

31 March 2020

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Supercoil-driven DNA structures regulate genetic transactions

31 March 2020

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c-myc gene is transcribed at high rate in G0-arrested fibroblasts and is post-transcriptionally regulated in response to growth factors

31 March 2020

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Rapid cytoplasmic turnover of c-myc mRNA: requirement of the 3' untranslated sequences

31 March 2020

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Poly(A) shortening and degradation of the 3' A+U-rich sequences of human c-myc mRNA in a cell-free system

31 March 2020

1 reference

Control of c-myc mRNA half-life in vitro by a protein capable of binding to a coding region stability determinant

31 March 2020

1 reference

Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development

31 March 2020

1 reference

The myc oncogene: its role in transformation and differentiation

31 March 2020

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The role of myc oncogenes in cell growth and differentiation

31 March 2020

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A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas

31 March 2020

1 reference

Role of post-translational modifications in regulating c-Myc proteolysis, transcriptional activity and biological function

31 March 2020

1 reference

The ins and outs of MYC regulation by posttranslational mechanisms

31 March 2020

1 reference

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

31 March 2020

1 reference

A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins

31 March 2020

1 reference

Identification of downstream-initiated c-Myc proteins which are dominant-negative inhibitors of transactivation by full-length c-Myc proteins

31 March 2020

1 reference

Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs

31 March 2020

1 reference

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

31 March 2020

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Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

31 March 2020

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

31 March 2020

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Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

31 March 2020

1 reference

31 March 2020

The Hallmarks of Cancer

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Oncogenic pathway signatures in human cancers as a guide to targeted therapies

31 March 2020

1 reference

Functional role for c-myc in mitogenic response to platelet-derived growth factor

31 March 2020

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Translocation of a store of maternal cytoplasmic c-myc protein into nuclei during early development

31 March 2020

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Is c-myc protein directly involved in DNA replication?

31 March 2020

1 reference

dMyc is required for larval growth and endoreplication in Drosophila

31 March 2020

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Drosophila dMyc is required for ovary cell growth and endoreplication

31 March 2020

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Non-transcriptional control of DNA replication by c-Myc

31 March 2020

1 reference

New light on Myc and Myb. Part I. Myc.

31 March 2020

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Regulation of heat shock protein 70 gene expression by c-myc.

31 March 2020

1 reference

The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins

31 March 2020

1 reference

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

31 March 2020

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Involvement of the 'leucine zipper' region in the oligomerization and transforming activity of human c-myc protein.

31 March 2020

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Definition of regions in human c-myc that are involved in transformation and nuclear localization

31 March 2020

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An amino-terminal c-myc domain required for neoplastic transformation activates transcription

31 March 2020

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Sequence-specific DNA binding by the c-Myc protein

31 March 2020

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Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region

31 March 2020

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Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc

31 March 2020

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Oncogenic activity of the c-Myc protein requires dimerization with Max.

31 March 2020

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Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity

31 March 2020

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Mnt takes control as key regulator of the myc/max/mxd network

31 March 2020

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The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

31 March 2020

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The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc

31 March 2020

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c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function

31 March 2020

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Myc influences global chromatin structure.

31 March 2020

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c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism

31 March 2020

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Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter

31 March 2020

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The Myc transactivation domain promotes global phosphorylation of the RNA polymerase II carboxy-terminal domain independently of direct DNA binding

31 March 2020

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Mechanism of transcriptional activation by the Myc oncoproteins

31 March 2020

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Transcriptional regulation and transformation by Myc proteins

31 March 2020

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Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlapping

31 March 2020

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Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis

31 March 2020

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A link between c-Myc-mediated transcriptional repression and neoplastic transformation

31 March 2020

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c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II

31 March 2020

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Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression

31 March 2020

1 reference

The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation

31 March 2020

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Promoter-binding and repression of PDGFRB by c-Myc are separable activities

31 March 2020

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Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

31 March 2020

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The MYC protein activates transcription of the alpha-prothymosin gene.

31 March 2020

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The ornithine decarboxylase gene is a transcriptional target of c-Myc

31 March 2020

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A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

31 March 2020

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Posttranslational regulation of proteins by fusions to steroid-binding domains

31 March 2020

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c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets

31 March 2020

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Myc represses the growth arrest gene gadd45

31 March 2020

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An E-box-mediated increase in cad transcription at the G1/S-phase boundary is suppressed by inhibitory c-Myc mutants

31 March 2020

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Identifying genes regulated in a Myc-dependent manner

31 March 2020

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The c-Myc target gene network

31 March 2020

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An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

31 March 2020

1 reference

The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis

31 March 2020

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Myc-binding-site recognition in the human genome is determined by chromatin context

31 March 2020

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Global mapping of c-Myc binding sites and target gene networks in human B cells

31 March 2020

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Analysis of genomic targets reveals complex functions of MYC.

31 March 2020

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Integration of external signaling pathways with the core transcriptional network in embryonic stem cells

31 March 2020

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31 March 2020

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c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription.

31 March 2020

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c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

31 March 2020

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Direct activation of RNA polymerase III transcription by c-Myc

31 March 2020

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Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development.

31 March 2020

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The interplay between MYC and HIF in cancer.

31 March 2020

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c-Myc-regulated microRNAs modulate E2F1 expression

31 March 2020

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A microRNA polycistron as a potential human oncogene

31 March 2020

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Myc in model organisms: a view from the flyroom

31 March 2020

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Analysis of C-MYC function in normal cells via conditional gene-targeted mutation

31 March 2020

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c-Myc regulates mammalian body size by controlling cell number but not cell size

31 March 2020

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Mysterious liaisons: the relationship between c-Myc and the cell cycle.

31 March 2020

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The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice

31 March 2020

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Constitutive c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitment.

31 March 2020

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c-Myc promotes differentiation of human epidermal stem cells

31 March 2020

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Deregulated expression of c-myc by murine erythroleukaemia cells prevents differentiation

31 March 2020

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Expression of a transfected human c-myconcogene inhibits differentiation of a mouse erythroleukaemia cell line

31 March 2020

1 reference

The MAX-interacting transcription factor network

31 March 2020

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The Myc/Max/Mad network and the transcriptional control of cell behavior

31 March 2020

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The basic region/helix-loop-helix/leucine zipper domain of Myc proto-oncoproteins: function and regulation

31 March 2020

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The Max network gone mad.

31 March 2020

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c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

31 March 2020

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c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression

31 March 2020

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The protooncogene c-myc is an essential regulator of neural crest formation in xenopus.

31 March 2020

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N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation

31 March 2020

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Control of cell growth by c-Myc in the absence of cell division

31 March 2020

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c-Myc enhances protein synthesis and cell size during B lymphocyte development

31 March 2020

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c-Myc target genes involved in cell growth, apoptosis, and metabolism

31 March 2020

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The role of c-myc in regulation of translation initiation

31 March 2020

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Genomic instability in MycER-activated Rat1A-MycER cells

31 March 2020

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c-Myc overexpression uncouples DNA replication from mitosis

31 March 2020

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Transient excess of MYC activity can elicit genomic instability and tumorigenesis

31 March 2020

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C-myc overexpression and p53 loss cooperate to promote genomic instability

31 March 2020

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The ever expanding role for c-Myc in promoting genomic instability

31 March 2020

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Myc-Is this the oncogene from Hell?

31 March 2020

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Could MYC induction of mitochondrial biogenesis be linked to ROS production and genomic instability?

31 March 2020

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c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus

31 March 2020

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p19ARF directly and differentially controls the functions of c-Myc independently of p53.

31 March 2020

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Functional and physical communication between oncoproteins and tumor suppressors

31 March 2020

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Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

31 March 2020

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c-Myc is necessary for DNA damage-induced apoptosis in the G(2) phase of the cell cycle

31 March 2020

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The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo.

31 March 2020

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Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster

31 March 2020

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Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis

31 March 2020

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Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

31 March 2020

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Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion

31 March 2020

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c-MYC: more than just a matter of life and death

31 March 2020

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Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors

31 March 2020

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Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas

31 March 2020

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Induction of apoptosis in fibroblasts by c-myc protein

31 March 2020

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c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

31 March 2020

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The Oscar-worthy role of Myc in apoptosis

31 March 2020

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Cooperative interaction between c-myc and bcl-2 proto-oncogenes

31 March 2020

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Apoptotic cell death induced by c-myc is inhibited by bcl-2.

31 March 2020

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Myc potentiates apoptosis by stimulating Bax activity at the mitochondria

31 March 2020

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c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death

31 March 2020

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The great MYC escape in tumorigenesis

31 March 2020

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c-Myc blazing a trail of death: coupling of the mitochondrial and death receptor apoptosis pathways by c-Myc

31 March 2020

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Mediation of c-Myc-induced apoptosis by p53.

31 March 2020

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Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

31 March 2020

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

31 March 2020

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Negative regulation of the mammalian UV response by Myc through association with Miz-1

31 March 2020

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Repression of p15INK4b expression by Myc through association with Miz-1

31 March 2020

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Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3.

31 March 2020

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Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

31 March 2020

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Bcl-xL gain of function and p19 ARF loss of function cooperate oncogenically with Myc in vivo by distinct mechanisms

31 March 2020

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

31 March 2020

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INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

31 March 2020

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FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf.

31 March 2020

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Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis

31 March 2020

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Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

31 March 2020

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Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

31 March 2020

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CUL7 is a novel antiapoptotic oncogene

31 March 2020

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Twist is a potential oncogene that inhibits apoptosis

31 March 2020

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Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging

31 March 2020

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Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1.

31 March 2020

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Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis

31 March 2020

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c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-XL

31 March 2020

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Specific requirement for Bax, not Bak, in Myc-induced apoptosis and tumor suppression in vivo

31 March 2020

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c-Myc functionally cooperates with Bax to induce apoptosis

31 March 2020

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Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

31 March 2020

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Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis

31 March 2020

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Bim is a suppressor of Myc-induced mouse B cell leukemia

31 March 2020

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Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

31 March 2020

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Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC.

31 March 2020

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Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype

31 March 2020

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Myc and Max homologs in Drosophila

31 March 2020

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Myc, cell competition, and compensatory proliferation

31 March 2020

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A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice

31 March 2020

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c-Myc is required for the formation of intestinal crypts but dispensable for homeostasis of the adult intestinal epithelium

31 March 2020

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Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene

31 March 2020

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Hypertrophic growth in cardiac myocytes is mediated by Myc through a Cyclin D2-dependent pathway

31 March 2020

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N-myc coordinates retinal growth with eye size during mouse development.

31 March 2020

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N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development

31 March 2020

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Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors.

31 March 2020

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Reversible tumorigenesis by MYC in hematopoietic lineages

31 March 2020

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Conditional transgenic models define how MYC initiates and maintains tumorigenesis

31 March 2020

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31 March 2020

The many faces of c-MYC.

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Sustained loss of a neoplastic phenotype by brief inactivation of MYC

31 March 2020

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Lack of sustained regression of c-MYC-induced mammary adenocarcinomas following brief or prolonged MYC inactivation

31 March 2020

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c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations

31 March 2020

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Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas

31 March 2020

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Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras

31 March 2020

1 reference

The world according to MYC. Conference on MYC and the transcriptional control of proliferation and oncogenesis

31 March 2020

1 reference

25 years of the c-Myc oncogene

31 March 2020

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Myc-driven murine prostate cancer shares molecular features with human prostate tumors

31 March 2020

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Transformation of follicular lymphoma to diffuse large-cell lymphoma: alternative patterns with increased or decreased expression of c-myc and its regulated genes

31 March 2020

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Genetic regulators of large-scale transcriptional signatures in cancer

31 March 2020

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The Myc oncoprotein as a therapeutic target for human cancer

31 March 2020

1 reference

Cancer therapeutics: targeting the dark side of Myc.

31 March 2020

1 reference

Drug targeting of the c-MYC promoter to repress gene expression via a G-quadruplex silencer element

31 March 2020

1 reference

Mechanisms of Disease: cancer stem cells--targeting the evil twin

31 March 2020

1 reference

c-Myc and downstream targets in the pathogenesis and treatment of cancer.

31 March 2020

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c-Myc as a therapeutic target in cancer

31 March 2020

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Genomic targets of the human c-Myc protein

31 March 2020

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MYC in mammalian epidermis: how can an oncogene stimulate differentiation?

31 March 2020

1 reference

The molecular genetics of cellular oncogenes

31 March 2020

1 reference

Drosophila myc regulates cellular growth during development.

31 March 2020

1 reference

Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network

31 March 2020

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Polycomb mediates Myc autorepression and its transcriptional control of many loci in Drosophila

31 March 2020

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The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster

31 March 2020

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The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth

31 March 2020

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Drosophila myc regulates organ size by inducing cell competition

31 March 2020

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dMyc transforms cells into super-competitors

31 March 2020

1 reference

Why myc? An unexpected ingredient in the stem cell cocktail

31 March 2020

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LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism.

31 March 2020

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Generation of germline-competent induced pluripotent stem cells

31 March 2020

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In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

31 March 2020

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Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts

31 March 2020

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A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

31 March 2020

1 reference

MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

31 March 2020

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Module map of stem cell genes guides creation of epithelial cancer stem cells

31 March 2020

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An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors

31 March 2020

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Combined analysis of murine and human microarrays and ChIP analysis reveals genes associated with the ability of MYC to maintain tumorigenesis

31 March 2020

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The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression

31 March 2020

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The Kaposi's sarcoma-associated herpesvirus LANA protein stabilizes and activates c-Myc

31 March 2020

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Epstein-Barr virus nuclear antigen 3C interacts with and enhances the stability of the c-Myc oncoprotein

31 March 2020

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Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

31 March 2020

1 reference

Defining the temporal requirements for Myc in the progression and maintenance of skin neoplasia

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC2231

1 reference

19 August 2017

1 reference

PubMed ID

19029958